Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013

Christian Bjerregaard-Olesen, Cathrine C Bach, Manhai Long, Mandana Ghisari, Rossana Bossi, Bodil H Bech, Ellen A Nohr, Tine B Henriksen, Jørn Olsen, Eva C Bonefeld-Jørgensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We aimed to estimate the levels and time trends of perfluorinated alkyl acids (PFAAs) in serum of 1533 Danish pregnant nulliparous women between 2008 and 2013. The selection criterion of only including nulliparous women was chosen to avoid confounding from parity. The serum samples were analyzed for sixteen PFAAs using solid phase extraction and liquid chromatography tandem mass spectrometry (LC-MS/MS). We investigated the time trends for seven PFAAs, which were detected in more than 50% of the samples: perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnA). We found that the serum levels of all seven PFAAs decreased during the period from 2008 to 2013; on average PFHxS decreased with 7.0% per year, PFHpS with 14.8%, PFOS with 9.3%, PFOA with 9.1%, PFNA with 6.2%, PFDA with 6.3%, and PFUnA with 7.1% per year. Adjustment for maternal age, body mass index (BMI), educational level and gestational age at blood sampling did not change the time trends much. To our knowledge, we are the first to report decreasing trends of PFNA, PFDA and PFUnA since year 2000, thereby indicating that the phase-out of these compounds are beginning to show an effect on human serum levels.

OriginalsprogEngelsk
TidsskriftEnvironment International
Vol/bind91
Sider (fra-til)14-21
ISSN0160-4120
DOI
StatusUdgivet - 2016

Fingeraftryk

serum
acid
sulfonate
woman
trend
body mass
liquid chromatography
mass spectrometry
blood

Citer dette

Bjerregaard-Olesen, C., Bach, C. C., Long, M., Ghisari, M., Bossi, R., Bech, B. H., ... Bonefeld-Jørgensen, E. C. (2016). Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013. Environment International, 91, 14-21. https://doi.org/10.1016/j.envint.2016.02.010
Bjerregaard-Olesen, Christian ; Bach, Cathrine C ; Long, Manhai ; Ghisari, Mandana ; Bossi, Rossana ; Bech, Bodil H ; Nohr, Ellen A ; Henriksen, Tine B ; Olsen, Jørn ; Bonefeld-Jørgensen, Eva C. / Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013. I: Environment International. 2016 ; Bind 91. s. 14-21.
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title = "Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013",
abstract = "We aimed to estimate the levels and time trends of perfluorinated alkyl acids (PFAAs) in serum of 1533 Danish pregnant nulliparous women between 2008 and 2013. The selection criterion of only including nulliparous women was chosen to avoid confounding from parity. The serum samples were analyzed for sixteen PFAAs using solid phase extraction and liquid chromatography tandem mass spectrometry (LC-MS/MS). We investigated the time trends for seven PFAAs, which were detected in more than 50{\%} of the samples: perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnA). We found that the serum levels of all seven PFAAs decreased during the period from 2008 to 2013; on average PFHxS decreased with 7.0{\%} per year, PFHpS with 14.8{\%}, PFOS with 9.3{\%}, PFOA with 9.1{\%}, PFNA with 6.2{\%}, PFDA with 6.3{\%}, and PFUnA with 7.1{\%} per year. Adjustment for maternal age, body mass index (BMI), educational level and gestational age at blood sampling did not change the time trends much. To our knowledge, we are the first to report decreasing trends of PFNA, PFDA and PFUnA since year 2000, thereby indicating that the phase-out of these compounds are beginning to show an effect on human serum levels.",
keywords = "Adult, Alkanesulfonic Acids, Chromatography, Liquid, Denmark, Environmental Monitoring, Fatty Acids, Female, Fluorocarbons, Humans, Pregnancy, Journal Article, Research Support, Non-U.S. Gov't",
author = "Christian Bjerregaard-Olesen and Bach, {Cathrine C} and Manhai Long and Mandana Ghisari and Rossana Bossi and Bech, {Bodil H} and Nohr, {Ellen A} and Henriksen, {Tine B} and J{\o}rn Olsen and Bonefeld-J{\o}rgensen, {Eva C}",
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year = "2016",
doi = "10.1016/j.envint.2016.02.010",
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Bjerregaard-Olesen, C, Bach, CC, Long, M, Ghisari, M, Bossi, R, Bech, BH, Nohr, EA, Henriksen, TB, Olsen, J & Bonefeld-Jørgensen, EC 2016, 'Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013', Environment International, bind 91, s. 14-21. https://doi.org/10.1016/j.envint.2016.02.010

Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013. / Bjerregaard-Olesen, Christian; Bach, Cathrine C; Long, Manhai; Ghisari, Mandana; Bossi, Rossana; Bech, Bodil H; Nohr, Ellen A; Henriksen, Tine B; Olsen, Jørn; Bonefeld-Jørgensen, Eva C.

I: Environment International, Bind 91, 2016, s. 14-21.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013

AU - Bjerregaard-Olesen, Christian

AU - Bach, Cathrine C

AU - Long, Manhai

AU - Ghisari, Mandana

AU - Bossi, Rossana

AU - Bech, Bodil H

AU - Nohr, Ellen A

AU - Henriksen, Tine B

AU - Olsen, Jørn

AU - Bonefeld-Jørgensen, Eva C

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016

Y1 - 2016

N2 - We aimed to estimate the levels and time trends of perfluorinated alkyl acids (PFAAs) in serum of 1533 Danish pregnant nulliparous women between 2008 and 2013. The selection criterion of only including nulliparous women was chosen to avoid confounding from parity. The serum samples were analyzed for sixteen PFAAs using solid phase extraction and liquid chromatography tandem mass spectrometry (LC-MS/MS). We investigated the time trends for seven PFAAs, which were detected in more than 50% of the samples: perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnA). We found that the serum levels of all seven PFAAs decreased during the period from 2008 to 2013; on average PFHxS decreased with 7.0% per year, PFHpS with 14.8%, PFOS with 9.3%, PFOA with 9.1%, PFNA with 6.2%, PFDA with 6.3%, and PFUnA with 7.1% per year. Adjustment for maternal age, body mass index (BMI), educational level and gestational age at blood sampling did not change the time trends much. To our knowledge, we are the first to report decreasing trends of PFNA, PFDA and PFUnA since year 2000, thereby indicating that the phase-out of these compounds are beginning to show an effect on human serum levels.

AB - We aimed to estimate the levels and time trends of perfluorinated alkyl acids (PFAAs) in serum of 1533 Danish pregnant nulliparous women between 2008 and 2013. The selection criterion of only including nulliparous women was chosen to avoid confounding from parity. The serum samples were analyzed for sixteen PFAAs using solid phase extraction and liquid chromatography tandem mass spectrometry (LC-MS/MS). We investigated the time trends for seven PFAAs, which were detected in more than 50% of the samples: perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnA). We found that the serum levels of all seven PFAAs decreased during the period from 2008 to 2013; on average PFHxS decreased with 7.0% per year, PFHpS with 14.8%, PFOS with 9.3%, PFOA with 9.1%, PFNA with 6.2%, PFDA with 6.3%, and PFUnA with 7.1% per year. Adjustment for maternal age, body mass index (BMI), educational level and gestational age at blood sampling did not change the time trends much. To our knowledge, we are the first to report decreasing trends of PFNA, PFDA and PFUnA since year 2000, thereby indicating that the phase-out of these compounds are beginning to show an effect on human serum levels.

KW - Adult

KW - Alkanesulfonic Acids

KW - Chromatography, Liquid

KW - Denmark

KW - Environmental Monitoring

KW - Fatty Acids

KW - Female

KW - Fluorocarbons

KW - Humans

KW - Pregnancy

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.envint.2016.02.010

DO - 10.1016/j.envint.2016.02.010

M3 - Journal article

C2 - 26891270

VL - 91

SP - 14

EP - 21

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -