Time to insulin initiation can not be used in defining Latent Autoimmune Diabetes in Adults [LADA]

S Brophy, K Yderstræde, D Mauricio, S Hunter, M Hawa, P Pozzilli, G Schernthaner, N Schloot, R Buzzetti, H Davies, Rdg Leslie, D R R Williams, Action LADA Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2007-Dec-14
OriginalsprogEngelsk
TidsskriftDiabetes Care
Antal sider3
ISSN0149-5992
DOI
StatusUdgivet - 14. dec. 2007

Fingeraftryk

Glutamate Decarboxylase
Insulin
Patient Selection
Latent Autoimmune Diabetes in Adults

Citer dette

Brophy, S ; Yderstræde, K ; Mauricio, D ; Hunter, S ; Hawa, M ; Pozzilli, P ; Schernthaner, G ; Schloot, N ; Buzzetti, R ; Davies, H ; Leslie, Rdg ; Williams, D R R ; LADA Group, Action. / Time to insulin initiation can not be used in defining Latent Autoimmune Diabetes in Adults [LADA]. I: Diabetes Care. 2007.
@article{7c546f70da4111dc860c000ea68e967b,
title = "Time to insulin initiation can not be used in defining Latent Autoimmune Diabetes in Adults [LADA]",
abstract = "Objective: Latent Autoimmune Diabetes in Adults [LADA] is type 1 diabetes presenting as non-insulin dependent diabetes. One feature of the selection criteria is time independent of insulin treatment. We examine the validity of this criterion. Methods: Patients were recruited in 9 European centres and clinicians reported on criteria for initiating insulin. All patients were tested for glutamic acid decarboxylase autoantibodies (GADA) in a central laboratory. We examined time to insulin treatment for GADA positive patients in 6 participating centres. Results: There was inter-centre variation in the criteria used to initiate insulin. Median time to insulin was 16.15 months (IQR: 6.7 - 25.5) in centres with GADA testing compared to 45.6 months (IQR: 29.5-61.8) in centres without routine GADA testing (p<0.002). Conclusions: Time to insulin should not be used to define patients with LADA as it is dependent on local clinical judgment and the use of laboratory tests for GADA",
author = "S Brophy and K Yderstr{\ae}de and D Mauricio and S Hunter and M Hawa and P Pozzilli and G Schernthaner and N Schloot and R Buzzetti and H Davies and Rdg Leslie and Williams, {D R R} and {LADA Group}, Action",
year = "2007",
month = "12",
day = "14",
doi = "10.2337/dc07-1308",
language = "English",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",

}

Brophy, S, Yderstræde, K, Mauricio, D, Hunter, S, Hawa, M, Pozzilli, P, Schernthaner, G, Schloot, N, Buzzetti, R, Davies, H, Leslie, R, Williams, DRR & LADA Group, A 2007, 'Time to insulin initiation can not be used in defining Latent Autoimmune Diabetes in Adults [LADA]', Diabetes Care. https://doi.org/10.2337/dc07-1308

Time to insulin initiation can not be used in defining Latent Autoimmune Diabetes in Adults [LADA]. / Brophy, S; Yderstræde, K; Mauricio, D; Hunter, S; Hawa, M; Pozzilli, P; Schernthaner, G; Schloot, N; Buzzetti, R; Davies, H; Leslie, Rdg; Williams, D R R; LADA Group, Action.

I: Diabetes Care, 14.12.2007.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Time to insulin initiation can not be used in defining Latent Autoimmune Diabetes in Adults [LADA]

AU - Brophy, S

AU - Yderstræde, K

AU - Mauricio, D

AU - Hunter, S

AU - Hawa, M

AU - Pozzilli, P

AU - Schernthaner, G

AU - Schloot, N

AU - Buzzetti, R

AU - Davies, H

AU - Leslie, Rdg

AU - Williams, D R R

AU - LADA Group, Action

PY - 2007/12/14

Y1 - 2007/12/14

N2 - Objective: Latent Autoimmune Diabetes in Adults [LADA] is type 1 diabetes presenting as non-insulin dependent diabetes. One feature of the selection criteria is time independent of insulin treatment. We examine the validity of this criterion. Methods: Patients were recruited in 9 European centres and clinicians reported on criteria for initiating insulin. All patients were tested for glutamic acid decarboxylase autoantibodies (GADA) in a central laboratory. We examined time to insulin treatment for GADA positive patients in 6 participating centres. Results: There was inter-centre variation in the criteria used to initiate insulin. Median time to insulin was 16.15 months (IQR: 6.7 - 25.5) in centres with GADA testing compared to 45.6 months (IQR: 29.5-61.8) in centres without routine GADA testing (p<0.002). Conclusions: Time to insulin should not be used to define patients with LADA as it is dependent on local clinical judgment and the use of laboratory tests for GADA

AB - Objective: Latent Autoimmune Diabetes in Adults [LADA] is type 1 diabetes presenting as non-insulin dependent diabetes. One feature of the selection criteria is time independent of insulin treatment. We examine the validity of this criterion. Methods: Patients were recruited in 9 European centres and clinicians reported on criteria for initiating insulin. All patients were tested for glutamic acid decarboxylase autoantibodies (GADA) in a central laboratory. We examined time to insulin treatment for GADA positive patients in 6 participating centres. Results: There was inter-centre variation in the criteria used to initiate insulin. Median time to insulin was 16.15 months (IQR: 6.7 - 25.5) in centres with GADA testing compared to 45.6 months (IQR: 29.5-61.8) in centres without routine GADA testing (p<0.002). Conclusions: Time to insulin should not be used to define patients with LADA as it is dependent on local clinical judgment and the use of laboratory tests for GADA

U2 - 10.2337/dc07-1308

DO - 10.2337/dc07-1308

M3 - Journal article

C2 - 18083788

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

ER -