The purpose of the study was to identify factors that could predict differences among individuals in the time to failure of a submaximal contraction. Twenty subjects (10 men, 25+/-6 years) supported an inertial load equivalent to 20% of the maximal voluntary contraction (MVC) force with the elbow flexor muscles for as long as possible. The time to failure was predicted by the frequency of electromyographic bursts in the long head of biceps brachii during the first 20% of the contraction, the amplitude of bursts in the brachioradialis during the first 20% of the contraction, and the target torque. Subjects who could sustain the task longer exhibited greater initial (first 20% of contraction) electromyographic burst frequency in the long head of biceps brachii, lower initial burst amplitudes in the brachioradialis muscle, and lower target torque. Knowing the main predictors of a submaximal fatiguing contraction with the elbow flexor muscles may assist clinicians in personalizing therapeutic interventions.