Time scales of developmental toxicity impacting on research and needs for intervention

Philippe Grandjean, Latifa Abdennebi-Najar, Robert Barouki, Carl F Cranor, Ruth A Etzel, David Gee, Jerrold J Heindel, Karin S Hougaard, Patricia Hunt, Tim S Nawrot, Gail S Prins, Beate Ritz, Morando Soffritti, Jordi Sunyer, Pal Weihe

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Resumé

Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects that can be transgenerationally transferred to future generations. Although epidemiology and toxicology to an increasing degree are exploring the adverse effects from developmental exposures in human beings, the improved documentation has resulted in little progress in protection, and few environmental chemicals are currently regulated to protect against developmental toxicity, whether it be neurotoxicity, endocrine disruption or other adverse outcome. The desire to obtain a high degree of certainty and verification of the evidence used for decision-making must be weighed against the costs and necessary duration of research, as well as the long-term costs to human health because of delayed protection of vulnerable early-life stages of human development and, possibly, future generations. Although two-generation toxicology tests may be useful for initial test purposes, other rapidly emerging tools need to be seriously considered from computational chemistry and metabolomics to CLARITY-BPA-type designs, big data and population record linkage approaches that will allow efficient generation of new insight; epigenetic mechanisms may necessitate a set of additional regulatory tests to reveal such effects. As reflected by the Prenatal Programming and Toxicity (PPTOX) VI conference, the current scientific understanding and the timescales involved require an intensified approach to protect against preventable adverse health effects that can harm the next generation and generations to come. While further research is needed, the main emphasis should be on research translation and timely public health intervention to avoid serious, irreversible and perhaps transgenerational harm.

OriginalsprogEngelsk
TidsskriftBasic & Clinical Pharmacology & Toxicology
Vol/bind125
Udgave nummerSuppl. 3
Sider (fra-til)70-80
ISSN1742-7835
DOI
StatusUdgivet - aug. 2019

Fingeraftryk

Toxicity
Research
Health
Computational chemistry
Epidemiology
Public health
Epigenomics
Documentation
Costs
Hazards
Public Health
Decision making
Population
Big data
Metabolomics

Citer dette

Grandjean, Philippe ; Abdennebi-Najar, Latifa ; Barouki, Robert ; Cranor, Carl F ; Etzel, Ruth A ; Gee, David ; Heindel, Jerrold J ; Hougaard, Karin S ; Hunt, Patricia ; Nawrot, Tim S ; Prins, Gail S ; Ritz, Beate ; Soffritti, Morando ; Sunyer, Jordi ; Weihe, Pal. / Time scales of developmental toxicity impacting on research and needs for intervention. I: Basic & Clinical Pharmacology & Toxicology. 2019 ; Bind 125, Nr. Suppl. 3. s. 70-80.
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title = "Time scales of developmental toxicity impacting on research and needs for intervention",
abstract = "Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects that can be transgenerationally transferred to future generations. Although epidemiology and toxicology to an increasing degree are exploring the adverse effects from developmental exposures in human beings, the improved documentation has resulted in little progress in protection, and few environmental chemicals are currently regulated to protect against developmental toxicity, whether it be neurotoxicity, endocrine disruption or other adverse outcome. The desire to obtain a high degree of certainty and verification of the evidence used for decision-making must be weighed against the costs and necessary duration of research, as well as the long-term costs to human health because of delayed protection of vulnerable early-life stages of human development and, possibly, future generations. Although two-generation toxicology tests may be useful for initial test purposes, other rapidly emerging tools need to be seriously considered from computational chemistry and metabolomics to CLARITY-BPA-type designs, big data and population record linkage approaches that will allow efficient generation of new insight; epigenetic mechanisms may necessitate a set of additional regulatory tests to reveal such effects. As reflected by the Prenatal Programming and Toxicity (PPTOX) VI conference, the current scientific understanding and the timescales involved require an intensified approach to protect against preventable adverse health effects that can harm the next generation and generations to come. While further research is needed, the main emphasis should be on research translation and timely public health intervention to avoid serious, irreversible and perhaps transgenerational harm.",
author = "Philippe Grandjean and Latifa Abdennebi-Najar and Robert Barouki and Cranor, {Carl F} and Etzel, {Ruth A} and David Gee and Heindel, {Jerrold J} and Hougaard, {Karin S} and Patricia Hunt and Nawrot, {Tim S} and Prins, {Gail S} and Beate Ritz and Morando Soffritti and Jordi Sunyer and Pal Weihe",
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year = "2019",
month = "8",
doi = "10.1111/bcpt.13162",
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Grandjean, P, Abdennebi-Najar, L, Barouki, R, Cranor, CF, Etzel, RA, Gee, D, Heindel, JJ, Hougaard, KS, Hunt, P, Nawrot, TS, Prins, GS, Ritz, B, Soffritti, M, Sunyer, J & Weihe, P 2019, 'Time scales of developmental toxicity impacting on research and needs for intervention', Basic & Clinical Pharmacology & Toxicology, bind 125, nr. Suppl. 3, s. 70-80. https://doi.org/10.1111/bcpt.13162

Time scales of developmental toxicity impacting on research and needs for intervention. / Grandjean, Philippe; Abdennebi-Najar, Latifa; Barouki, Robert; Cranor, Carl F; Etzel, Ruth A; Gee, David; Heindel, Jerrold J; Hougaard, Karin S; Hunt, Patricia; Nawrot, Tim S; Prins, Gail S; Ritz, Beate; Soffritti, Morando; Sunyer, Jordi; Weihe, Pal.

I: Basic & Clinical Pharmacology & Toxicology, Bind 125, Nr. Suppl. 3, 08.2019, s. 70-80.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Time scales of developmental toxicity impacting on research and needs for intervention

AU - Grandjean, Philippe

AU - Abdennebi-Najar, Latifa

AU - Barouki, Robert

AU - Cranor, Carl F

AU - Etzel, Ruth A

AU - Gee, David

AU - Heindel, Jerrold J

AU - Hougaard, Karin S

AU - Hunt, Patricia

AU - Nawrot, Tim S

AU - Prins, Gail S

AU - Ritz, Beate

AU - Soffritti, Morando

AU - Sunyer, Jordi

AU - Weihe, Pal

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/8

Y1 - 2019/8

N2 - Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects that can be transgenerationally transferred to future generations. Although epidemiology and toxicology to an increasing degree are exploring the adverse effects from developmental exposures in human beings, the improved documentation has resulted in little progress in protection, and few environmental chemicals are currently regulated to protect against developmental toxicity, whether it be neurotoxicity, endocrine disruption or other adverse outcome. The desire to obtain a high degree of certainty and verification of the evidence used for decision-making must be weighed against the costs and necessary duration of research, as well as the long-term costs to human health because of delayed protection of vulnerable early-life stages of human development and, possibly, future generations. Although two-generation toxicology tests may be useful for initial test purposes, other rapidly emerging tools need to be seriously considered from computational chemistry and metabolomics to CLARITY-BPA-type designs, big data and population record linkage approaches that will allow efficient generation of new insight; epigenetic mechanisms may necessitate a set of additional regulatory tests to reveal such effects. As reflected by the Prenatal Programming and Toxicity (PPTOX) VI conference, the current scientific understanding and the timescales involved require an intensified approach to protect against preventable adverse health effects that can harm the next generation and generations to come. While further research is needed, the main emphasis should be on research translation and timely public health intervention to avoid serious, irreversible and perhaps transgenerational harm.

AB - Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects that can be transgenerationally transferred to future generations. Although epidemiology and toxicology to an increasing degree are exploring the adverse effects from developmental exposures in human beings, the improved documentation has resulted in little progress in protection, and few environmental chemicals are currently regulated to protect against developmental toxicity, whether it be neurotoxicity, endocrine disruption or other adverse outcome. The desire to obtain a high degree of certainty and verification of the evidence used for decision-making must be weighed against the costs and necessary duration of research, as well as the long-term costs to human health because of delayed protection of vulnerable early-life stages of human development and, possibly, future generations. Although two-generation toxicology tests may be useful for initial test purposes, other rapidly emerging tools need to be seriously considered from computational chemistry and metabolomics to CLARITY-BPA-type designs, big data and population record linkage approaches that will allow efficient generation of new insight; epigenetic mechanisms may necessitate a set of additional regulatory tests to reveal such effects. As reflected by the Prenatal Programming and Toxicity (PPTOX) VI conference, the current scientific understanding and the timescales involved require an intensified approach to protect against preventable adverse health effects that can harm the next generation and generations to come. While further research is needed, the main emphasis should be on research translation and timely public health intervention to avoid serious, irreversible and perhaps transgenerational harm.

U2 - 10.1111/bcpt.13162

DO - 10.1111/bcpt.13162

M3 - Review

C2 - 30387920

VL - 125

SP - 70

EP - 80

JO - Basic & Clinical Pharmacology & Toxicology

JF - Basic & Clinical Pharmacology & Toxicology

SN - 1742-7835

IS - Suppl. 3

ER -