Thyroid hormone induced oxygen consumption and glucose-uptake in human mononuclear cells

J Kvetny, L E Matzen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1989-Apr
OriginalsprogEngelsk
TidsskriftThyroidology
Vol/bind1
Udgave nummer1
Sider (fra-til)5-9
Antal sider4
ISSN1121-7596
StatusUdgivet - 1989

Fingeraftryk

Oxygen Consumption
Insulin
Oxidative Phosphorylation
Lactic Acid

Citer dette

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title = "Thyroid hormone induced oxygen consumption and glucose-uptake in human mononuclear cells",
abstract = "Cellular oxygen consumption and glucose metabolism were examined in human mononuclear blood cells. The cellular oxygen consumption and glucose uptake were dependent on the number of cells, the temperature and the duration of incubation. Stimulation of the cells by T4 and T3 led to a dose dependent increase of oxygen consumption and glucose uptake, whereas T2 and rT3 had no effect. Thyroxine as well as T3 stimulated the cellular glucose metabolism, but lactate production was independent of T3 and T4 stimulation. The data suggested a direct effect of T4 and T3 on oxidative phosphorylation. Further thyroid hormones and insulin exerted an additive effect on glucose uptake. Our study indicates a direct intracellular effect of T4 independent of its conversion to T3 and a different mechanism for insulin dependent and thyroid hormone glucose uptake.",
keywords = "Adult, Blood Glucose, Humans, Leukocyte Count, Leukocytes, Mononuclear, Oxygen Consumption, Temperature, Thyroid Hormones",
author = "J Kvetny and Matzen, {L E}",
year = "1989",
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Thyroid hormone induced oxygen consumption and glucose-uptake in human mononuclear cells. / Kvetny, J; Matzen, L E.

I: Thyroidology, Bind 1, Nr. 1, 1989, s. 5-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Thyroid hormone induced oxygen consumption and glucose-uptake in human mononuclear cells

AU - Kvetny, J

AU - Matzen, L E

PY - 1989

Y1 - 1989

N2 - Cellular oxygen consumption and glucose metabolism were examined in human mononuclear blood cells. The cellular oxygen consumption and glucose uptake were dependent on the number of cells, the temperature and the duration of incubation. Stimulation of the cells by T4 and T3 led to a dose dependent increase of oxygen consumption and glucose uptake, whereas T2 and rT3 had no effect. Thyroxine as well as T3 stimulated the cellular glucose metabolism, but lactate production was independent of T3 and T4 stimulation. The data suggested a direct effect of T4 and T3 on oxidative phosphorylation. Further thyroid hormones and insulin exerted an additive effect on glucose uptake. Our study indicates a direct intracellular effect of T4 independent of its conversion to T3 and a different mechanism for insulin dependent and thyroid hormone glucose uptake.

AB - Cellular oxygen consumption and glucose metabolism were examined in human mononuclear blood cells. The cellular oxygen consumption and glucose uptake were dependent on the number of cells, the temperature and the duration of incubation. Stimulation of the cells by T4 and T3 led to a dose dependent increase of oxygen consumption and glucose uptake, whereas T2 and rT3 had no effect. Thyroxine as well as T3 stimulated the cellular glucose metabolism, but lactate production was independent of T3 and T4 stimulation. The data suggested a direct effect of T4 and T3 on oxidative phosphorylation. Further thyroid hormones and insulin exerted an additive effect on glucose uptake. Our study indicates a direct intracellular effect of T4 independent of its conversion to T3 and a different mechanism for insulin dependent and thyroid hormone glucose uptake.

KW - Adult

KW - Blood Glucose

KW - Humans

KW - Leukocyte Count

KW - Leukocytes, Mononuclear

KW - Oxygen Consumption

KW - Temperature

KW - Thyroid Hormones

M3 - Journal article

VL - 1

SP - 5

EP - 9

JO - Thyroidology

JF - Thyroidology

SN - 1121-7596

IS - 1

ER -