Third trimester cortisol status is associated with offspring sex and polycystic ovary syndrome status

Odense Child Cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during the third trimester and to examine associations between maternal cortisol status, offspring sex, and maternal polycystic ovary syndrome (PCOS) status. Design: Prospective observational study. Setting: The study is part of the prospective Odense Child Cohort. Patient(s): The study cohort included 1,489 women (with PCOS, n = 145; without PCOS, n = 1,344). Intervention(s): Fasting blood samples, 24-hour urinary samples. Main Outcome Measure(s): Fasting morning S-cortisol and 24-hour U-cortisol/U-cortisone (24-hour U-C/C) were collected at gestational week 28 and measured by liquid chromatography–tandem mass spectrometry. Result(s): Maternal S-cortisol levels were significantly higher in women pregnant with girls (n = 702) vs. boys (n = 787): mean (mean − SD; mean + SD) 833 (643; 1,079) vs. 799 (588; 1,083) nmol/L. In multiple regression analyses, maternal S-cortisol was positively associated with female offspring and inversely associated with maternal age and parity. When women were divided according to PCOS status, 24-hour U-cortisone was higher: 467 (334; 652) vs. 415 (286; 604) nmol/24 hours; and 24-hour U-C/C was lower in women with PCOS compared with women without PCOS. Conclusion(s): Maternal third trimester S-cortisol levels were positively associated with female offspring. Cortisol metabolism was higher in women with PCOS vs. women without PCOS.

OriginalsprogEngelsk
TidsskriftFertility and Sterility
Vol/bind112
Udgave nummer4
Sider (fra-til)764-772
ISSN0015-0282
DOI
StatusUdgivet - okt. 2019

Fingeraftryk

Polycystic Ovary Syndrome
Third Pregnancy Trimester
Mothers
Cortisone
Fasting
Maternal Age
Parity
Pregnant Women
Cohort Studies
Regression Analysis
Outcome Assessment (Health Care)
Prospective Studies
Serum

Citer dette

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title = "Third trimester cortisol status is associated with offspring sex and polycystic ovary syndrome status: Odense Child Cohort",
abstract = "Objective: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during the third trimester and to examine associations between maternal cortisol status, offspring sex, and maternal polycystic ovary syndrome (PCOS) status. Design: Prospective observational study. Setting: The study is part of the prospective Odense Child Cohort. Patient(s): The study cohort included 1,489 women (with PCOS, n = 145; without PCOS, n = 1,344). Intervention(s): Fasting blood samples, 24-hour urinary samples. Main Outcome Measure(s): Fasting morning S-cortisol and 24-hour U-cortisol/U-cortisone (24-hour U-C/C) were collected at gestational week 28 and measured by liquid chromatography–tandem mass spectrometry. Result(s): Maternal S-cortisol levels were significantly higher in women pregnant with girls (n = 702) vs. boys (n = 787): mean (mean − SD; mean + SD) 833 (643; 1,079) vs. 799 (588; 1,083) nmol/L. In multiple regression analyses, maternal S-cortisol was positively associated with female offspring and inversely associated with maternal age and parity. When women were divided according to PCOS status, 24-hour U-cortisone was higher: 467 (334; 652) vs. 415 (286; 604) nmol/24 hours; and 24-hour U-C/C was lower in women with PCOS compared with women without PCOS. Conclusion(s): Maternal third trimester S-cortisol levels were positively associated with female offspring. Cortisol metabolism was higher in women with PCOS vs. women without PCOS.",
keywords = "Cortisol, Odense Child Cohort, PCOS",
author = "Andersen, {Marianne Skovsager} and Jensen, {Richard Christian} and Schmedes, {Anne Vibeke} and Ivan Brandslund and Kyhl, {Henriette Boye} and Jensen, {Tina Kold} and Dorte Glintborg",
year = "2019",
month = "10",
doi = "10.1016/j.fertnstert.2019.05.013",
language = "English",
volume = "112",
pages = "764--772",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Third trimester cortisol status is associated with offspring sex and polycystic ovary syndrome status

T2 - Odense Child Cohort

AU - Andersen, Marianne Skovsager

AU - Jensen, Richard Christian

AU - Schmedes, Anne Vibeke

AU - Brandslund, Ivan

AU - Kyhl, Henriette Boye

AU - Jensen, Tina Kold

AU - Glintborg, Dorte

PY - 2019/10

Y1 - 2019/10

N2 - Objective: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during the third trimester and to examine associations between maternal cortisol status, offspring sex, and maternal polycystic ovary syndrome (PCOS) status. Design: Prospective observational study. Setting: The study is part of the prospective Odense Child Cohort. Patient(s): The study cohort included 1,489 women (with PCOS, n = 145; without PCOS, n = 1,344). Intervention(s): Fasting blood samples, 24-hour urinary samples. Main Outcome Measure(s): Fasting morning S-cortisol and 24-hour U-cortisol/U-cortisone (24-hour U-C/C) were collected at gestational week 28 and measured by liquid chromatography–tandem mass spectrometry. Result(s): Maternal S-cortisol levels were significantly higher in women pregnant with girls (n = 702) vs. boys (n = 787): mean (mean − SD; mean + SD) 833 (643; 1,079) vs. 799 (588; 1,083) nmol/L. In multiple regression analyses, maternal S-cortisol was positively associated with female offspring and inversely associated with maternal age and parity. When women were divided according to PCOS status, 24-hour U-cortisone was higher: 467 (334; 652) vs. 415 (286; 604) nmol/24 hours; and 24-hour U-C/C was lower in women with PCOS compared with women without PCOS. Conclusion(s): Maternal third trimester S-cortisol levels were positively associated with female offspring. Cortisol metabolism was higher in women with PCOS vs. women without PCOS.

AB - Objective: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during the third trimester and to examine associations between maternal cortisol status, offspring sex, and maternal polycystic ovary syndrome (PCOS) status. Design: Prospective observational study. Setting: The study is part of the prospective Odense Child Cohort. Patient(s): The study cohort included 1,489 women (with PCOS, n = 145; without PCOS, n = 1,344). Intervention(s): Fasting blood samples, 24-hour urinary samples. Main Outcome Measure(s): Fasting morning S-cortisol and 24-hour U-cortisol/U-cortisone (24-hour U-C/C) were collected at gestational week 28 and measured by liquid chromatography–tandem mass spectrometry. Result(s): Maternal S-cortisol levels were significantly higher in women pregnant with girls (n = 702) vs. boys (n = 787): mean (mean − SD; mean + SD) 833 (643; 1,079) vs. 799 (588; 1,083) nmol/L. In multiple regression analyses, maternal S-cortisol was positively associated with female offspring and inversely associated with maternal age and parity. When women were divided according to PCOS status, 24-hour U-cortisone was higher: 467 (334; 652) vs. 415 (286; 604) nmol/24 hours; and 24-hour U-C/C was lower in women with PCOS compared with women without PCOS. Conclusion(s): Maternal third trimester S-cortisol levels were positively associated with female offspring. Cortisol metabolism was higher in women with PCOS vs. women without PCOS.

KW - Cortisol

KW - Odense Child Cohort

KW - PCOS

U2 - 10.1016/j.fertnstert.2019.05.013

DO - 10.1016/j.fertnstert.2019.05.013

M3 - Journal article

VL - 112

SP - 764

EP - 772

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 4

ER -