The Western Denmark Cardiac Computed Tomography Registry

a review and validation study

Lene Hüche Nielsen, Bjarne Linde Nørgaard, Hans Henrik Tilsted, Niels Peter Sand, Jesper Møller Jensen, Morten Bøttcher, Axel C Diederichsen, Jess Lambrechtsen, Lone Deibjerg Kristensen, Hans Mickley, Henrik Munkholm, Ole Gøtzsche, Lars Lyhne Knudsen, Hans Erik Bøtker, Lars Pedersen, Morten Schmidt

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

BACKGROUND: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.

OBJECTIVE: We examined the content, data quality, and research potential of the WDHR-CCTR.

METHODS: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.

RESULTS: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating >90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was >85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%).

CONCLUSION: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.

OriginalsprogEngelsk
TidsskriftClinical Epidemiology
Vol/bind7
Sider (fra-til)53-64
ISSN1179-1349
DOI
StatusUdgivet - 2015

Fingeraftryk

Validation Studies
Denmark
Registries
Medical Records
Research
Coronary Artery Disease
Databases

Citer dette

Nielsen, L. H., Nørgaard, B. L., Tilsted, H. H., Sand, N. P., Jensen, J. M., Bøttcher, M., ... Schmidt, M. (2015). The Western Denmark Cardiac Computed Tomography Registry: a review and validation study. Clinical Epidemiology, 7, 53-64. https://doi.org/10.2147/CLEP.S73728
Nielsen, Lene Hüche ; Nørgaard, Bjarne Linde ; Tilsted, Hans Henrik ; Sand, Niels Peter ; Jensen, Jesper Møller ; Bøttcher, Morten ; Diederichsen, Axel C ; Lambrechtsen, Jess ; Kristensen, Lone Deibjerg ; Mickley, Hans ; Munkholm, Henrik ; Gøtzsche, Ole ; Knudsen, Lars Lyhne ; Bøtker, Hans Erik ; Pedersen, Lars ; Schmidt, Morten. / The Western Denmark Cardiac Computed Tomography Registry : a review and validation study. I: Clinical Epidemiology. 2015 ; Bind 7. s. 53-64.
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title = "The Western Denmark Cardiac Computed Tomography Registry: a review and validation study",
abstract = "BACKGROUND: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.OBJECTIVE: We examined the content, data quality, and research potential of the WDHR-CCTR.METHODS: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.RESULTS: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87{\%} were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72{\%}. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23{\%} of all nonregistered cardiac CTs, indicating >90{\%} completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0{\%}-100{\%}), but was >85{\%} for more than 70{\%} of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89{\%} to 100{\%} (overall 97{\%}), whereas the negative predictive value ranged from 97{\%} to 100{\%} (overall 99{\%}). Stratification by center status showed consistently high positive and negative predictive values for both university (96{\%}/99{\%}) and nonuniversity centers (97{\%}/99{\%}).CONCLUSION: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.",
author = "Nielsen, {Lene H{\"u}che} and N{\o}rgaard, {Bjarne Linde} and Tilsted, {Hans Henrik} and Sand, {Niels Peter} and Jensen, {Jesper M{\o}ller} and Morten B{\o}ttcher and Diederichsen, {Axel C} and Jess Lambrechtsen and Kristensen, {Lone Deibjerg} and Hans Mickley and Henrik Munkholm and Ole G{\o}tzsche and Knudsen, {Lars Lyhne} and B{\o}tker, {Hans Erik} and Lars Pedersen and Morten Schmidt",
year = "2015",
doi = "10.2147/CLEP.S73728",
language = "English",
volume = "7",
pages = "53--64",
journal = "Clinical Epidemiology",
issn = "1179-1349",
publisher = "Dove Medical Press Ltd.(Dovepress)",

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Nielsen, LH, Nørgaard, BL, Tilsted, HH, Sand, NP, Jensen, JM, Bøttcher, M, Diederichsen, AC, Lambrechtsen, J, Kristensen, LD, Mickley, H, Munkholm, H, Gøtzsche, O, Knudsen, LL, Bøtker, HE, Pedersen, L & Schmidt, M 2015, 'The Western Denmark Cardiac Computed Tomography Registry: a review and validation study', Clinical Epidemiology, bind 7, s. 53-64. https://doi.org/10.2147/CLEP.S73728

The Western Denmark Cardiac Computed Tomography Registry : a review and validation study. / Nielsen, Lene Hüche; Nørgaard, Bjarne Linde; Tilsted, Hans Henrik; Sand, Niels Peter; Jensen, Jesper Møller; Bøttcher, Morten; Diederichsen, Axel C; Lambrechtsen, Jess; Kristensen, Lone Deibjerg; Mickley, Hans; Munkholm, Henrik; Gøtzsche, Ole; Knudsen, Lars Lyhne; Bøtker, Hans Erik; Pedersen, Lars; Schmidt, Morten.

I: Clinical Epidemiology, Bind 7, 2015, s. 53-64.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Western Denmark Cardiac Computed Tomography Registry

T2 - a review and validation study

AU - Nielsen, Lene Hüche

AU - Nørgaard, Bjarne Linde

AU - Tilsted, Hans Henrik

AU - Sand, Niels Peter

AU - Jensen, Jesper Møller

AU - Bøttcher, Morten

AU - Diederichsen, Axel C

AU - Lambrechtsen, Jess

AU - Kristensen, Lone Deibjerg

AU - Mickley, Hans

AU - Munkholm, Henrik

AU - Gøtzsche, Ole

AU - Knudsen, Lars Lyhne

AU - Bøtker, Hans Erik

AU - Pedersen, Lars

AU - Schmidt, Morten

PY - 2015

Y1 - 2015

N2 - BACKGROUND: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.OBJECTIVE: We examined the content, data quality, and research potential of the WDHR-CCTR.METHODS: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.RESULTS: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating >90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was >85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%).CONCLUSION: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.

AB - BACKGROUND: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.OBJECTIVE: We examined the content, data quality, and research potential of the WDHR-CCTR.METHODS: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.RESULTS: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating >90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was >85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%).CONCLUSION: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.

U2 - 10.2147/CLEP.S73728

DO - 10.2147/CLEP.S73728

M3 - Journal article

VL - 7

SP - 53

EP - 64

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -