The Western Denmark Cardiac Computed Tomography Registry: a review and validation study

Lene Hüche Nielsen, Bjarne Linde Nørgaard, Hans Henrik Tilsted, Niels Peter Sand, Jesper Møller Jensen, Morten Bøttcher, Axel C Diederichsen, Jess Lambrechtsen, Lone Deibjerg Kristensen, Hans Mickley, Henrik Munkholm, Ole Gøtzsche, Lars Lyhne Knudsen, Hans Erik Bøtker, Lars Pedersen, Morten Schmidt

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Abstrakt

BACKGROUND: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.

OBJECTIVE: We examined the content, data quality, and research potential of the WDHR-CCTR.

METHODS: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.

RESULTS: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating >90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was >85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%).

CONCLUSION: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.

OriginalsprogEngelsk
TidsskriftClinical Epidemiology
Vol/bind7
Sider (fra-til)53-64
ISSN1179-1349
DOI
StatusUdgivet - 31. dec. 2014

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