The use of olfactory testing when diagnosing parkinson’s disease - A systematic review

Tine Nielsen*, Martin Bang Jensen, Egon Stenager, Andreas Dammann Andersen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

21 Downloads (Pure)

Resumé

INTRODUCTION: The diagnosis of Parkinson’s disease (PD) is typically based on the presence of motor symptoms, but in the early phase of the disease, the diagnostic process can be challenging. Examination of non-motor symptoms in patients suspected of PD has gained growing attention. Olfactory tests have shown promising results as ancillary diagnostic tests. The aim of this study was to investigate how olfactory tests may be used clinically in diagnostic process in PD. METHODS: A systematic search was conducted in PubMed for relevant literature on 8 March 2017. A total of 358 articles were found. Our screening process left 27 articles, which were included for further analysis. RESULTS: In all, 20 of the included studies analysed the diagnostic value of olfactory testing by comparing patients with PD to healthy controls. Sensitivities varied from 61% to 95% and specificities from 66% to 99%. Ten studies used olfactory tests to distinguish between PD and diseases that mimic PD. The sensitivities varied from 62% to 92% and the specificities from 65% and 96%. CONCLUSIONS: Olfactory test can be a valuable ancillary tool in the diagnostic process in PD. In a clinical setting, the identification part from Sniffin’ Sticks 16 is the most usable because it may be conducted quickly and independently of disease duration and severity. Before using an olfactory test in a clinical setting, it is necessary to adjust the odours to the patient population, and to establish the optimal specificity-adjusted cut-off.

OriginalsprogEngelsk
ArtikelnummerA5481
TidsskriftDanish Medical Journal
Vol/bind65
Udgave nummer5
Antal sider10
ISSN1603-9629
StatusUdgivet - 2018

Fingeraftryk

Parkinson Disease
Routine Diagnostic Tests
PubMed
Population

Citer dette

Nielsen, Tine ; Jensen, Martin Bang ; Stenager, Egon ; Andersen, Andreas Dammann. / The use of olfactory testing when diagnosing parkinson’s disease - A systematic review. I: Danish Medical Journal. 2018 ; Bind 65, Nr. 5.
@article{e15bd53894f843e9a6f505a49226b0e7,
title = "The use of olfactory testing when diagnosing parkinson’s disease - A systematic review",
abstract = "INTRODUCTION: The diagnosis of Parkinson’s disease (PD) is typically based on the presence of motor symptoms, but in the early phase of the disease, the diagnostic process can be challenging. Examination of non-motor symptoms in patients suspected of PD has gained growing attention. Olfactory tests have shown promising results as ancillary diagnostic tests. The aim of this study was to investigate how olfactory tests may be used clinically in diagnostic process in PD. METHODS: A systematic search was conducted in PubMed for relevant literature on 8 March 2017. A total of 358 articles were found. Our screening process left 27 articles, which were included for further analysis. RESULTS: In all, 20 of the included studies analysed the diagnostic value of olfactory testing by comparing patients with PD to healthy controls. Sensitivities varied from 61{\%} to 95{\%} and specificities from 66{\%} to 99{\%}. Ten studies used olfactory tests to distinguish between PD and diseases that mimic PD. The sensitivities varied from 62{\%} to 92{\%} and the specificities from 65{\%} and 96{\%}. CONCLUSIONS: Olfactory test can be a valuable ancillary tool in the diagnostic process in PD. In a clinical setting, the identification part from Sniffin’ Sticks 16 is the most usable because it may be conducted quickly and independently of disease duration and severity. Before using an olfactory test in a clinical setting, it is necessary to adjust the odours to the patient population, and to establish the optimal specificity-adjusted cut-off.",
author = "Tine Nielsen and Jensen, {Martin Bang} and Egon Stenager and Andersen, {Andreas Dammann}",
year = "2018",
language = "English",
volume = "65",
journal = "Danish Medical Journal",
issn = "1603-9629",
publisher = "DANISH MEDICAL ASSOC",
number = "5",

}

The use of olfactory testing when diagnosing parkinson’s disease - A systematic review. / Nielsen, Tine; Jensen, Martin Bang; Stenager, Egon; Andersen, Andreas Dammann.

I: Danish Medical Journal, Bind 65, Nr. 5, A5481, 2018.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - The use of olfactory testing when diagnosing parkinson’s disease - A systematic review

AU - Nielsen, Tine

AU - Jensen, Martin Bang

AU - Stenager, Egon

AU - Andersen, Andreas Dammann

PY - 2018

Y1 - 2018

N2 - INTRODUCTION: The diagnosis of Parkinson’s disease (PD) is typically based on the presence of motor symptoms, but in the early phase of the disease, the diagnostic process can be challenging. Examination of non-motor symptoms in patients suspected of PD has gained growing attention. Olfactory tests have shown promising results as ancillary diagnostic tests. The aim of this study was to investigate how olfactory tests may be used clinically in diagnostic process in PD. METHODS: A systematic search was conducted in PubMed for relevant literature on 8 March 2017. A total of 358 articles were found. Our screening process left 27 articles, which were included for further analysis. RESULTS: In all, 20 of the included studies analysed the diagnostic value of olfactory testing by comparing patients with PD to healthy controls. Sensitivities varied from 61% to 95% and specificities from 66% to 99%. Ten studies used olfactory tests to distinguish between PD and diseases that mimic PD. The sensitivities varied from 62% to 92% and the specificities from 65% and 96%. CONCLUSIONS: Olfactory test can be a valuable ancillary tool in the diagnostic process in PD. In a clinical setting, the identification part from Sniffin’ Sticks 16 is the most usable because it may be conducted quickly and independently of disease duration and severity. Before using an olfactory test in a clinical setting, it is necessary to adjust the odours to the patient population, and to establish the optimal specificity-adjusted cut-off.

AB - INTRODUCTION: The diagnosis of Parkinson’s disease (PD) is typically based on the presence of motor symptoms, but in the early phase of the disease, the diagnostic process can be challenging. Examination of non-motor symptoms in patients suspected of PD has gained growing attention. Olfactory tests have shown promising results as ancillary diagnostic tests. The aim of this study was to investigate how olfactory tests may be used clinically in diagnostic process in PD. METHODS: A systematic search was conducted in PubMed for relevant literature on 8 March 2017. A total of 358 articles were found. Our screening process left 27 articles, which were included for further analysis. RESULTS: In all, 20 of the included studies analysed the diagnostic value of olfactory testing by comparing patients with PD to healthy controls. Sensitivities varied from 61% to 95% and specificities from 66% to 99%. Ten studies used olfactory tests to distinguish between PD and diseases that mimic PD. The sensitivities varied from 62% to 92% and the specificities from 65% and 96%. CONCLUSIONS: Olfactory test can be a valuable ancillary tool in the diagnostic process in PD. In a clinical setting, the identification part from Sniffin’ Sticks 16 is the most usable because it may be conducted quickly and independently of disease duration and severity. Before using an olfactory test in a clinical setting, it is necessary to adjust the odours to the patient population, and to establish the optimal specificity-adjusted cut-off.

M3 - Review

AN - SCOPUS:85046341391

VL - 65

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 1603-9629

IS - 5

M1 - A5481

ER -