The tumor necrosis factor alpha - 308G>A polymorphism is associated with dementia in the oldest-old.

Helle Bruunsgaard, Thomas L Benfield, Karen Andersen-Ranberg, Jacob v B Hjelmborg, Agnes N Pedersen, Marianne Schroll, Bente K Pedersen, Bernard Jeune

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2004-Aug
OriginalsprogEngelsk
TidsskriftJournal of the American Geriatrics Society
Vol/bind52
Udgave nummer8
Sider (fra-til)1361-1366
Antal sider5
ISSN0002-8614
DOI
StatusUdgivet - 2004

Fingeraftryk

Tumor Necrosis Factor-alpha
Longitudinal Studies
Age Groups
Regression Analysis
Statistical Factor Analysis
Logistic Models
Alleles
Population

Citer dette

Bruunsgaard, Helle ; Benfield, Thomas L ; Andersen-Ranberg, Karen ; Hjelmborg, Jacob v B ; Pedersen, Agnes N ; Schroll, Marianne ; Pedersen, Bente K ; Jeune, Bernard. / The tumor necrosis factor alpha - 308G>A polymorphism is associated with dementia in the oldest-old. I: Journal of the American Geriatrics Society. 2004 ; Bind 52, Nr. 8. s. 1361-1366.
@article{47623f00f49f11db821c000ea68e967b,
title = "The tumor necrosis factor alpha - 308G>A polymorphism is associated with dementia in the oldest-old.",
abstract = "OBJECTIVES: To test the hypothesis that the tumor necrosis factor (TNF) -308 G>A promoter gene polymorphism is a risk factor in age-related dementia and longevity. DESIGN: A cross-sectional and a longitudinal study. SETTING: A population-based sample of Danish centenarians. PARTICIPANTS: One hundred-year-old Danes (n=122) from {"}The Longitudinal Study of Danish Centenarians.{"} Octogenarians (n=174) and healthy volunteers aged 18 to 30 (n=47) served as reference groups. METHODS: Whether the distribution of TNF -308 GG/GA/AA genotypes were different in centenarians than in younger age groups was investigated (Fischer exact test). Furthermore, whether the TNF -308 G>A polymorphism was associated with the prevalence of dementia (logistic regression analysis), the plasma level of TNF-alpha (analysis of variance), and mortality in the following 5 years (Cox regression analysis) within the cohort of centenarians was tested. RESULTS: The distribution of TNF -308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha, but the significance was questionable due to a low number of subjects with this genotype. CONCLUSION: It is possible that the TNF -308 A allele is maintained during aging because subjects who are heterozygous for this polymorphism possess the optimal inflammatory response with regard to protection against age-related neurodegeneration.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Dementia, Female, Genotype, Humans, Longitudinal Studies, Male, Polymorphism, Genetic, Regression Analysis, Tumor Necrosis Factor-alpha",
author = "Helle Bruunsgaard and Benfield, {Thomas L} and Karen Andersen-Ranberg and Hjelmborg, {Jacob v B} and Pedersen, {Agnes N} and Marianne Schroll and Pedersen, {Bente K} and Bernard Jeune",
year = "2004",
doi = "10.1111/j.1532-5415.2004.52369.x",
language = "English",
volume = "52",
pages = "1361--1366",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell Publishing",
number = "8",

}

The tumor necrosis factor alpha - 308G>A polymorphism is associated with dementia in the oldest-old. / Bruunsgaard, Helle; Benfield, Thomas L; Andersen-Ranberg, Karen; Hjelmborg, Jacob v B; Pedersen, Agnes N; Schroll, Marianne; Pedersen, Bente K; Jeune, Bernard.

I: Journal of the American Geriatrics Society, Bind 52, Nr. 8, 2004, s. 1361-1366.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The tumor necrosis factor alpha - 308G>A polymorphism is associated with dementia in the oldest-old.

AU - Bruunsgaard, Helle

AU - Benfield, Thomas L

AU - Andersen-Ranberg, Karen

AU - Hjelmborg, Jacob v B

AU - Pedersen, Agnes N

AU - Schroll, Marianne

AU - Pedersen, Bente K

AU - Jeune, Bernard

PY - 2004

Y1 - 2004

N2 - OBJECTIVES: To test the hypothesis that the tumor necrosis factor (TNF) -308 G>A promoter gene polymorphism is a risk factor in age-related dementia and longevity. DESIGN: A cross-sectional and a longitudinal study. SETTING: A population-based sample of Danish centenarians. PARTICIPANTS: One hundred-year-old Danes (n=122) from "The Longitudinal Study of Danish Centenarians." Octogenarians (n=174) and healthy volunteers aged 18 to 30 (n=47) served as reference groups. METHODS: Whether the distribution of TNF -308 GG/GA/AA genotypes were different in centenarians than in younger age groups was investigated (Fischer exact test). Furthermore, whether the TNF -308 G>A polymorphism was associated with the prevalence of dementia (logistic regression analysis), the plasma level of TNF-alpha (analysis of variance), and mortality in the following 5 years (Cox regression analysis) within the cohort of centenarians was tested. RESULTS: The distribution of TNF -308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha, but the significance was questionable due to a low number of subjects with this genotype. CONCLUSION: It is possible that the TNF -308 A allele is maintained during aging because subjects who are heterozygous for this polymorphism possess the optimal inflammatory response with regard to protection against age-related neurodegeneration.

AB - OBJECTIVES: To test the hypothesis that the tumor necrosis factor (TNF) -308 G>A promoter gene polymorphism is a risk factor in age-related dementia and longevity. DESIGN: A cross-sectional and a longitudinal study. SETTING: A population-based sample of Danish centenarians. PARTICIPANTS: One hundred-year-old Danes (n=122) from "The Longitudinal Study of Danish Centenarians." Octogenarians (n=174) and healthy volunteers aged 18 to 30 (n=47) served as reference groups. METHODS: Whether the distribution of TNF -308 GG/GA/AA genotypes were different in centenarians than in younger age groups was investigated (Fischer exact test). Furthermore, whether the TNF -308 G>A polymorphism was associated with the prevalence of dementia (logistic regression analysis), the plasma level of TNF-alpha (analysis of variance), and mortality in the following 5 years (Cox regression analysis) within the cohort of centenarians was tested. RESULTS: The distribution of TNF -308 genotypes was not different across the three different age groups, but the GA genotype was associated with decreased prevalence of dementia in centenarians. The few centenarians with AA carrier status had higher mortality risk and tended to show higher plasma levels of TNF-alpha, but the significance was questionable due to a low number of subjects with this genotype. CONCLUSION: It is possible that the TNF -308 A allele is maintained during aging because subjects who are heterozygous for this polymorphism possess the optimal inflammatory response with regard to protection against age-related neurodegeneration.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cross-Sectional Studies

KW - Dementia

KW - Female

KW - Genotype

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Polymorphism, Genetic

KW - Regression Analysis

KW - Tumor Necrosis Factor-alpha

U2 - 10.1111/j.1532-5415.2004.52369.x

DO - 10.1111/j.1532-5415.2004.52369.x

M3 - Journal article

C2 - 15271127

VL - 52

SP - 1361

EP - 1366

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 8

ER -