Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lym-phangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, goats and humans. Despite its economic and medical-veterinary importance, our understanding concerning this organism’s transcriptional regulatory mechanisms is still limited. Here, we review the state of the art knowledge on transcriptional regulatory mechanisms of this pathogenic species, covering regulatory interactions mediated by two-component systems, transcription factors and sigma factors. Key transcriptional regulatory players involved in virulence and pathogenicity of C. pseudotuberculosis, such as the PhoPR system and DtxR, are in the focus of this review, as these regulators are promising targets for future vaccine design and drug development. We conclude that more experimental studies are needed to further understand the regulatory repertoire of this important zoonotic pathogen, and that regulators are promising targets for future vaccine design and drug development.
Bibliografisk noteFunding Information:
J.B. is grateful for support from H2020 grant RepoTrial (no. 777111) and his VILLUM Young Investigator grant (no. 13154). D.P. received support from CAPES (no. 88887.364607/2019-00) and M.T.D.P. from CNPq (no. 201336/2018-9), for their work at TUM in Ger-many. M.T.D.P.?s work was also supported by the German Research Foundation (under SFB924). V.A.C.A. is grateful for support from his CNPq Research Productivity grant (no. 305093/2015-0), CNPq Universal grant (no. 405233/2016-7) and FAPEMIG grant (no. APQ 02600-17). M.S.-A. received PhD fellowship funding from CONACYT (CVU659273) and the German Academic Exchange Service, DAAD (ref. 91693321). This study was financed in part by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior-Brasil (CAPES)-Finance Code 001.
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