Abstrakt
Four double-headed nucleosides were prepared by the CuAAC reaction. Hereby, a triazole-containing linker connects an additional thymine or adenine to the 2´-position of 2´-deoxyuridine, a thymine to the 5´-position of thymidine and a thymine to the 6¢-position of an LNA-thymidine monomer. Whereas no
conclusive recognition effects of the additional thymines were found when introduced in LNA or at the 5´-position, both thymine and adenine in the 2´-position were found to stabilise three-way junctions in
both dsDNA and DNA:RNA contexts and to give cross-strand interactions in a DNA-duplex, when specifically introduced in a so-called (+1)-zipper motif.
conclusive recognition effects of the additional thymines were found when introduced in LNA or at the 5´-position, both thymine and adenine in the 2´-position were found to stabilise three-way junctions in
both dsDNA and DNA:RNA contexts and to give cross-strand interactions in a DNA-duplex, when specifically introduced in a so-called (+1)-zipper motif.
Originalsprog | Engelsk |
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Tidsskrift | Organic & Biomolecular Chemistry |
Vol/bind | 9 |
Sider (fra-til) | 1381 - 1388 |
Antal sider | 8 |
ISSN | 1477-0520 |
DOI | |
Status | Udgivet - 2011 |