Resumé
conclusive recognition effects of the additional thymines were found when introduced in LNA or at the 5´-position, both thymine and adenine in the 2´-position were found to stabilise three-way junctions in
both dsDNA and DNA:RNA contexts and to give cross-strand interactions in a DNA-duplex, when specifically introduced in a so-called (+1)-zipper motif.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Organic & Biomolecular Chemistry |
| Vol/bind | 9 |
| Sider (fra-til) | 1381 - 1388 |
| Antal sider | 8 |
| ISSN | 1477-0520 |
| DOI | |
| Status | Udgivet - 2011 |
Citer dette
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The synthesis of double-headed nucleosides by the CuAAC reaction and their effect in secondary nucleic acid structures. / Jørgensen, Anna Søndergaard; Shaikh, Khalil Isak; Enderlin, Gerald; Ivarsen, Elise; Kumar, Surender; Nielsen, Poul.
I: Organic & Biomolecular Chemistry, Bind 9, 2011, s. 1381 - 1388.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - The synthesis of double-headed nucleosides by the CuAAC reaction and their effect in secondary nucleic acid structures
AU - Jørgensen, Anna Søndergaard
AU - Shaikh, Khalil Isak
AU - Enderlin, Gerald
AU - Ivarsen, Elise
AU - Kumar, Surender
AU - Nielsen, Poul
PY - 2011
Y1 - 2011
N2 - Four double-headed nucleosides were prepared by the CuAAC reaction. Hereby, a triazole-containing linker connects an additional thymine or adenine to the 2´-position of 2´-deoxyuridine, a thymine to the 5´-position of thymidine and a thymine to the 6¢-position of an LNA-thymidine monomer. Whereas no conclusive recognition effects of the additional thymines were found when introduced in LNA or at the 5´-position, both thymine and adenine in the 2´-position were found to stabilise three-way junctions in both dsDNA and DNA:RNA contexts and to give cross-strand interactions in a DNA-duplex, when specifically introduced in a so-called (+1)-zipper motif.
AB - Four double-headed nucleosides were prepared by the CuAAC reaction. Hereby, a triazole-containing linker connects an additional thymine or adenine to the 2´-position of 2´-deoxyuridine, a thymine to the 5´-position of thymidine and a thymine to the 6¢-position of an LNA-thymidine monomer. Whereas no conclusive recognition effects of the additional thymines were found when introduced in LNA or at the 5´-position, both thymine and adenine in the 2´-position were found to stabilise three-way junctions in both dsDNA and DNA:RNA contexts and to give cross-strand interactions in a DNA-duplex, when specifically introduced in a so-called (+1)-zipper motif.
U2 - 10.1039/c0ob00438c
DO - 10.1039/c0ob00438c
M3 - Journal article
VL - 9
SP - 1381
EP - 1388
JO - Organic & Biomolecular Chemistry
JF - Organic & Biomolecular Chemistry
SN - 1477-0520
ER -