The Survival of Spouses Marrying Into Longevity-Enriched Families

Jacob K Pedersen, Irma T Elo, Nicole Schupf, Thomas T Perls, Eric Stallard, Anatoliy I Yashin, Kaare Christensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Studies of longevity-enriched families are an important tool to gain insight into the mechanisms of exceptionally long and healthy lives. In the Long Life Family Study, the spouses of the members of the longevity-enriched families are often used as a control group. These spouses could be expected to have better health than the background population due to shared family environment with the longevity-enriched family members and due to assortative mating.

METHODS: A Danish cohort study of 5,363 offspring of long-lived siblings, born 1917-1982, and 4,498 "first spouses" of these offspring. For each offspring and spouse, 10 controls were drawn from a 5% random sample of the Danish population matched on birth year and sex. Mortality was assessed for ages 20-69 years during 1968-2013 based on prospectively collected registry data.

RESULTS: During the 45-year follow-up period, 437 offspring deaths and 502 offspring spouse deaths were observed. Compared with the background population, the hazard ratio for male offspring was 0.44 (95% confidence interval [CI]: 0.38-0.50) and for female offspring it was 0.57 (95% CI: 0.49-0.66). For male spouses, the hazard ratio was 0.66 (95% CI: 0.59-0.74), whereas for female spouses it was 0.64 (95% CI: 0.54-0.76). Sensitivity analyses in restricted samples gave similar results.

CONCLUSION: The mortality for ages 20-69 years of spouses marrying into longevity-enriched families is substantially lower than the mortality in the background population, although long-lived siblings participation bias may have contributed to the difference. This finding has implications for the use of spouses as controls in healthy aging and longevity studies, as environmental and/or genetic overmatching may occur.
OriginalsprogEngelsk
TidsskriftJournals of Gerontology. Series A: Biological Sciences & Medical Sciences
Vol/bind72
Udgave nummer1
Sider (fra-til)109-114
ISSN1079-5006
DOI
StatusUdgivet - 2017

Fingeraftryk

Spouses
Confidence Intervals
Population
Siblings
Registries
Cohort Studies
Control Groups
Health

Emneord

  • Long-lived families
  • Mortality
  • Offspring
  • Spousal overmatching

Citer dette

Pedersen, Jacob K ; Elo, Irma T ; Schupf, Nicole ; Perls, Thomas T ; Stallard, Eric ; Yashin, Anatoliy I ; Christensen, Kaare. / The Survival of Spouses Marrying Into Longevity-Enriched Families. I: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 2017 ; Bind 72, Nr. 1. s. 109-114.
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title = "The Survival of Spouses Marrying Into Longevity-Enriched Families",
abstract = "BACKGROUND: Studies of longevity-enriched families are an important tool to gain insight into the mechanisms of exceptionally long and healthy lives. In the Long Life Family Study, the spouses of the members of the longevity-enriched families are often used as a control group. These spouses could be expected to have better health than the background population due to shared family environment with the longevity-enriched family members and due to assortative mating.METHODS: A Danish cohort study of 5,363 offspring of long-lived siblings, born 1917-1982, and 4,498 {"}first spouses{"} of these offspring. For each offspring and spouse, 10 controls were drawn from a 5{\%} random sample of the Danish population matched on birth year and sex. Mortality was assessed for ages 20-69 years during 1968-2013 based on prospectively collected registry data.RESULTS: During the 45-year follow-up period, 437 offspring deaths and 502 offspring spouse deaths were observed. Compared with the background population, the hazard ratio for male offspring was 0.44 (95{\%} confidence interval [CI]: 0.38-0.50) and for female offspring it was 0.57 (95{\%} CI: 0.49-0.66). For male spouses, the hazard ratio was 0.66 (95{\%} CI: 0.59-0.74), whereas for female spouses it was 0.64 (95{\%} CI: 0.54-0.76). Sensitivity analyses in restricted samples gave similar results.CONCLUSION: The mortality for ages 20-69 years of spouses marrying into longevity-enriched families is substantially lower than the mortality in the background population, although long-lived siblings participation bias may have contributed to the difference. This finding has implications for the use of spouses as controls in healthy aging and longevity studies, as environmental and/or genetic overmatching may occur.",
keywords = "Long-lived families, Mortality, Offspring, Spousal overmatching",
author = "Pedersen, {Jacob K} and Elo, {Irma T} and Nicole Schupf and Perls, {Thomas T} and Eric Stallard and Yashin, {Anatoliy I} and Kaare Christensen",
note = "{\circledC} The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2017",
doi = "10.1093/gerona/glw159",
language = "English",
volume = "72",
pages = "109--114",
journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",
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The Survival of Spouses Marrying Into Longevity-Enriched Families. / Pedersen, Jacob K; Elo, Irma T; Schupf, Nicole; Perls, Thomas T; Stallard, Eric; Yashin, Anatoliy I; Christensen, Kaare.

I: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Bind 72, Nr. 1, 2017, s. 109-114.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Survival of Spouses Marrying Into Longevity-Enriched Families

AU - Pedersen, Jacob K

AU - Elo, Irma T

AU - Schupf, Nicole

AU - Perls, Thomas T

AU - Stallard, Eric

AU - Yashin, Anatoliy I

AU - Christensen, Kaare

N1 - © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Studies of longevity-enriched families are an important tool to gain insight into the mechanisms of exceptionally long and healthy lives. In the Long Life Family Study, the spouses of the members of the longevity-enriched families are often used as a control group. These spouses could be expected to have better health than the background population due to shared family environment with the longevity-enriched family members and due to assortative mating.METHODS: A Danish cohort study of 5,363 offspring of long-lived siblings, born 1917-1982, and 4,498 "first spouses" of these offspring. For each offspring and spouse, 10 controls were drawn from a 5% random sample of the Danish population matched on birth year and sex. Mortality was assessed for ages 20-69 years during 1968-2013 based on prospectively collected registry data.RESULTS: During the 45-year follow-up period, 437 offspring deaths and 502 offspring spouse deaths were observed. Compared with the background population, the hazard ratio for male offspring was 0.44 (95% confidence interval [CI]: 0.38-0.50) and for female offspring it was 0.57 (95% CI: 0.49-0.66). For male spouses, the hazard ratio was 0.66 (95% CI: 0.59-0.74), whereas for female spouses it was 0.64 (95% CI: 0.54-0.76). Sensitivity analyses in restricted samples gave similar results.CONCLUSION: The mortality for ages 20-69 years of spouses marrying into longevity-enriched families is substantially lower than the mortality in the background population, although long-lived siblings participation bias may have contributed to the difference. This finding has implications for the use of spouses as controls in healthy aging and longevity studies, as environmental and/or genetic overmatching may occur.

AB - BACKGROUND: Studies of longevity-enriched families are an important tool to gain insight into the mechanisms of exceptionally long and healthy lives. In the Long Life Family Study, the spouses of the members of the longevity-enriched families are often used as a control group. These spouses could be expected to have better health than the background population due to shared family environment with the longevity-enriched family members and due to assortative mating.METHODS: A Danish cohort study of 5,363 offspring of long-lived siblings, born 1917-1982, and 4,498 "first spouses" of these offspring. For each offspring and spouse, 10 controls were drawn from a 5% random sample of the Danish population matched on birth year and sex. Mortality was assessed for ages 20-69 years during 1968-2013 based on prospectively collected registry data.RESULTS: During the 45-year follow-up period, 437 offspring deaths and 502 offspring spouse deaths were observed. Compared with the background population, the hazard ratio for male offspring was 0.44 (95% confidence interval [CI]: 0.38-0.50) and for female offspring it was 0.57 (95% CI: 0.49-0.66). For male spouses, the hazard ratio was 0.66 (95% CI: 0.59-0.74), whereas for female spouses it was 0.64 (95% CI: 0.54-0.76). Sensitivity analyses in restricted samples gave similar results.CONCLUSION: The mortality for ages 20-69 years of spouses marrying into longevity-enriched families is substantially lower than the mortality in the background population, although long-lived siblings participation bias may have contributed to the difference. This finding has implications for the use of spouses as controls in healthy aging and longevity studies, as environmental and/or genetic overmatching may occur.

KW - Long-lived families

KW - Mortality

KW - Offspring

KW - Spousal overmatching

U2 - 10.1093/gerona/glw159

DO - 10.1093/gerona/glw159

M3 - Journal article

VL - 72

SP - 109

EP - 114

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

IS - 1

ER -