The strong but nonspecific relationship between 18F-FDG uptake in the lower-extremity veins and venous thromboembolism

Hongyun June Zhu, Søren Hess, Domenico Rubello, Michael L Goris, Abass Alavi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Venous thromboembolism (VTE) can present as deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). In fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT, F-FDG activity along the deep veins of the lower extremities (LE) is often observed and, unless it is associated with focal intense activity, is not considered abnormal. However, anecdotally it has been associated with the placement of an inferior vena cava filter. In this short paper we intend to investigate this association. We found 10 patients who were investigated in the vascular laboratory by means of either LE or upper-extremity duplex or a chest computed tomography with PE protocol, or who had undergone the placement of an inferior vena cava filter between 27 April 2010 and 7 January 2013 and who had also undergone one or more F-FDG-PET scan(s) that included the LE. Seventeen patients without venous F-FDG uptake were added as controls. F-FDG uptake visualized in the LE was scored as the number of positive LE veins and the extent of the radiotracer uptake. The time intervals between the VTE event and the F-FDG-PET scan(s) were recorded. The time intervals between the most remote and the closest F-FDG-PET before a VTE event averaged 79±101 and 49±82 days, respectively, and the closest and the most remote F-FDG-PET after the VTE event averaged 58±50 and 122±124 days. The extent of uptake in the LE veins averaged 7±2 for the patients with an acute DVT on LE duplex and 5±3 for those with negative or chronic DVT on LE duplex (P=nonsignificant). Two patients (n=3 and 10) were negative for VTE events and had an extent of 0. The number of positive events correlated slightly with the extent of venous uptake (r=0.69). The 17 control patients without venous uptake on F-FDG-PET had no history of VTE. There was an association between LE venous uptake of F-FDG and risk for VTE. The association was not related to the location of the VTE, nor to the timing of the VTE.

OriginalsprogEngelsk
TidsskriftNuclear Medicine Communications
Vol/bind37
Udgave nummer3
Sider (fra-til)322-328
Antal sider7
ISSN0143-3636
DOI
StatusUdgivet - 2016

Fingeraftryk

Fluorodeoxyglucose F18
Vena Cava Filters

Citer dette

Zhu, Hongyun June ; Hess, Søren ; Rubello, Domenico ; Goris, Michael L ; Alavi, Abass. / The strong but nonspecific relationship between 18F-FDG uptake in the lower-extremity veins and venous thromboembolism. I: Nuclear Medicine Communications. 2016 ; Bind 37, Nr. 3. s. 322-328.
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title = "The strong but nonspecific relationship between 18F-FDG uptake in the lower-extremity veins and venous thromboembolism",
abstract = "Venous thromboembolism (VTE) can present as deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). In fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT, F-FDG activity along the deep veins of the lower extremities (LE) is often observed and, unless it is associated with focal intense activity, is not considered abnormal. However, anecdotally it has been associated with the placement of an inferior vena cava filter. In this short paper we intend to investigate this association. We found 10 patients who were investigated in the vascular laboratory by means of either LE or upper-extremity duplex or a chest computed tomography with PE protocol, or who had undergone the placement of an inferior vena cava filter between 27 April 2010 and 7 January 2013 and who had also undergone one or more F-FDG-PET scan(s) that included the LE. Seventeen patients without venous F-FDG uptake were added as controls. F-FDG uptake visualized in the LE was scored as the number of positive LE veins and the extent of the radiotracer uptake. The time intervals between the VTE event and the F-FDG-PET scan(s) were recorded. The time intervals between the most remote and the closest F-FDG-PET before a VTE event averaged 79±101 and 49±82 days, respectively, and the closest and the most remote F-FDG-PET after the VTE event averaged 58±50 and 122±124 days. The extent of uptake in the LE veins averaged 7±2 for the patients with an acute DVT on LE duplex and 5±3 for those with negative or chronic DVT on LE duplex (P=nonsignificant). Two patients (n=3 and 10) were negative for VTE events and had an extent of 0. The number of positive events correlated slightly with the extent of venous uptake (r=0.69). The 17 control patients without venous uptake on F-FDG-PET had no history of VTE. There was an association between LE venous uptake of F-FDG and risk for VTE. The association was not related to the location of the VTE, nor to the timing of the VTE.",
author = "Zhu, {Hongyun June} and S{\o}ren Hess and Domenico Rubello and Goris, {Michael L} and Abass Alavi",
year = "2016",
doi = "10.1097/MNM.0000000000000442",
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The strong but nonspecific relationship between 18F-FDG uptake in the lower-extremity veins and venous thromboembolism. / Zhu, Hongyun June; Hess, Søren; Rubello, Domenico; Goris, Michael L; Alavi, Abass.

I: Nuclear Medicine Communications, Bind 37, Nr. 3, 2016, s. 322-328.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The strong but nonspecific relationship between 18F-FDG uptake in the lower-extremity veins and venous thromboembolism

AU - Zhu, Hongyun June

AU - Hess, Søren

AU - Rubello, Domenico

AU - Goris, Michael L

AU - Alavi, Abass

PY - 2016

Y1 - 2016

N2 - Venous thromboembolism (VTE) can present as deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). In fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT, F-FDG activity along the deep veins of the lower extremities (LE) is often observed and, unless it is associated with focal intense activity, is not considered abnormal. However, anecdotally it has been associated with the placement of an inferior vena cava filter. In this short paper we intend to investigate this association. We found 10 patients who were investigated in the vascular laboratory by means of either LE or upper-extremity duplex or a chest computed tomography with PE protocol, or who had undergone the placement of an inferior vena cava filter between 27 April 2010 and 7 January 2013 and who had also undergone one or more F-FDG-PET scan(s) that included the LE. Seventeen patients without venous F-FDG uptake were added as controls. F-FDG uptake visualized in the LE was scored as the number of positive LE veins and the extent of the radiotracer uptake. The time intervals between the VTE event and the F-FDG-PET scan(s) were recorded. The time intervals between the most remote and the closest F-FDG-PET before a VTE event averaged 79±101 and 49±82 days, respectively, and the closest and the most remote F-FDG-PET after the VTE event averaged 58±50 and 122±124 days. The extent of uptake in the LE veins averaged 7±2 for the patients with an acute DVT on LE duplex and 5±3 for those with negative or chronic DVT on LE duplex (P=nonsignificant). Two patients (n=3 and 10) were negative for VTE events and had an extent of 0. The number of positive events correlated slightly with the extent of venous uptake (r=0.69). The 17 control patients without venous uptake on F-FDG-PET had no history of VTE. There was an association between LE venous uptake of F-FDG and risk for VTE. The association was not related to the location of the VTE, nor to the timing of the VTE.

AB - Venous thromboembolism (VTE) can present as deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). In fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT, F-FDG activity along the deep veins of the lower extremities (LE) is often observed and, unless it is associated with focal intense activity, is not considered abnormal. However, anecdotally it has been associated with the placement of an inferior vena cava filter. In this short paper we intend to investigate this association. We found 10 patients who were investigated in the vascular laboratory by means of either LE or upper-extremity duplex or a chest computed tomography with PE protocol, or who had undergone the placement of an inferior vena cava filter between 27 April 2010 and 7 January 2013 and who had also undergone one or more F-FDG-PET scan(s) that included the LE. Seventeen patients without venous F-FDG uptake were added as controls. F-FDG uptake visualized in the LE was scored as the number of positive LE veins and the extent of the radiotracer uptake. The time intervals between the VTE event and the F-FDG-PET scan(s) were recorded. The time intervals between the most remote and the closest F-FDG-PET before a VTE event averaged 79±101 and 49±82 days, respectively, and the closest and the most remote F-FDG-PET after the VTE event averaged 58±50 and 122±124 days. The extent of uptake in the LE veins averaged 7±2 for the patients with an acute DVT on LE duplex and 5±3 for those with negative or chronic DVT on LE duplex (P=nonsignificant). Two patients (n=3 and 10) were negative for VTE events and had an extent of 0. The number of positive events correlated slightly with the extent of venous uptake (r=0.69). The 17 control patients without venous uptake on F-FDG-PET had no history of VTE. There was an association between LE venous uptake of F-FDG and risk for VTE. The association was not related to the location of the VTE, nor to the timing of the VTE.

U2 - 10.1097/MNM.0000000000000442

DO - 10.1097/MNM.0000000000000442

M3 - Journal article

VL - 37

SP - 322

EP - 328

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 3

ER -