The Significance of Epidermal Lipid Metabolism in Whole-Body Physiology

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.

OriginalsprogEngelsk
TidsskriftTrends in Endocrinology and Metabolism
Vol/bind28
Udgave nummer9
Sider (fra-til)669-683
ISSN1043-2760
DOI
StatusUdgivet - 2017

Fingeraftryk

Lipid Metabolism
Skin
Skin Temperature
Human Body
Mammals

Citer dette

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title = "The Significance of Epidermal Lipid Metabolism in Whole-Body Physiology",
abstract = "The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.",
keywords = "Journal Article, Review",
author = "Vibeke Kruse and Ditte Neess and F{\ae}rgeman, {Nils J}",
note = "Copyright {\circledC} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
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volume = "28",
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journal = "Trends in Endocrinology and Metabolism",
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The Significance of Epidermal Lipid Metabolism in Whole-Body Physiology. / Kruse, Vibeke; Neess, Ditte; Færgeman, Nils J.

I: Trends in Endocrinology and Metabolism, Bind 28, Nr. 9, 2017, s. 669-683.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - The Significance of Epidermal Lipid Metabolism in Whole-Body Physiology

AU - Kruse, Vibeke

AU - Neess, Ditte

AU - Færgeman, Nils J

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017

Y1 - 2017

N2 - The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.

AB - The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.

KW - Journal Article

KW - Review

U2 - 10.1016/j.tem.2017.06.001

DO - 10.1016/j.tem.2017.06.001

M3 - Review

C2 - 28668301

VL - 28

SP - 669

EP - 683

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

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