The Significance of Epidermal Lipid Metabolism in Whole-Body Physiology

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Abstrakt

The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.

OriginalsprogEngelsk
TidsskriftTrends in Endocrinology and Metabolism
Vol/bind28
Udgave nummer9
Sider (fra-til)669-683
ISSN1043-2760
DOI
StatusUdgivet - 2017

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