The risk of asthma is increased among women with polycystic ovary syndrome: a twin study

Louise Zierau, Howraman Meteran, Vibeke Backer, Svend Lindenberg, Axel Skytthe, Simon Francis Thomsen

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Resumé

Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.

Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.

Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.

Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.

OriginalsprogEngelsk
Artikelnummer00018-2018
TidsskriftERJ Open Research
Vol/bind5
Udgave nummer3
Antal sider7
ISSN2312-0541
DOI
StatusUdgivet - jul. 2019

Fingeraftryk

Twin Studies
Polycystic Ovary Syndrome
Registries
International Classification of Diseases
Alcohol Drinking
Body Mass Index
Smoking

Citer dette

Zierau, Louise ; Meteran, Howraman ; Backer, Vibeke ; Lindenberg, Svend ; Skytthe, Axel ; Thomsen, Simon Francis. / The risk of asthma is increased among women with polycystic ovary syndrome : a twin study. I: ERJ Open Research. 2019 ; Bind 5, Nr. 3.
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abstract = "Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3{\%}) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18{\%} versus 9{\%}, respectively; OR 2.11 (95{\%} CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95{\%} CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49{\%} (95{\%} CI 24-68{\%}) and unique environmental factors explained 51{\%} (95{\%} CI 32-76{\%}) of the susceptibility to PCOS. For asthma, 44{\%} (95{\%} CI 28-61{\%}) of the variance was explained by genetic factors, whereas 25{\%} (95{\%} CI 11-38{\%}) was ascribable to shared environmental factors and 31{\%} (95{\%} CI 26-36{\%}) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.",
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The risk of asthma is increased among women with polycystic ovary syndrome : a twin study. / Zierau, Louise; Meteran, Howraman; Backer, Vibeke; Lindenberg, Svend; Skytthe, Axel; Thomsen, Simon Francis.

I: ERJ Open Research, Bind 5, Nr. 3, 00018-2018, 07.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The risk of asthma is increased among women with polycystic ovary syndrome

T2 - a twin study

AU - Zierau, Louise

AU - Meteran, Howraman

AU - Backer, Vibeke

AU - Lindenberg, Svend

AU - Skytthe, Axel

AU - Thomsen, Simon Francis

PY - 2019/7

Y1 - 2019/7

N2 - Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.

AB - Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.

U2 - 10.1183/23120541.00018-2018

DO - 10.1183/23120541.00018-2018

M3 - Journal article

C2 - 31544109

VL - 5

JO - ERJ Open Research

JF - ERJ Open Research

SN - 2312-0541

IS - 3

M1 - 00018-2018

ER -