The renin-angiotensin system; development and differentiation of the renal medulla

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Adverse events during fetal development can predispose the individual for cardiovascular disease later in life, a correlation known as fetal programming of adult hypertension. The "programming" events are not known but might reside in the kidneys due to these organs significant role in extracellular volume control and long term blood pressure regulation. Previously, nephron endowment and functional consequences of a low nephron number has been extensively investigated without achieving a full explanation of the underlying pathophysiological mechanisms. In this review, we will focus on mechanisms of postnatal development the renal medulla and putting medullary developmental lesions into perspective with regard to the programming effect. Moreover, the renin-angiotensin system is critically involved in mammalian kidney development and signaling disorders give rise to developmental renal lesions that has been associated with hypertension later in life. A consistent finding in both experimental animal models and in human case reports is atrophy of the renal medulla with developmental lesions to both medullary nephron segments and vascular development with concomitant functional disturbances reaching into adulthood. A review of current knowledge of the role of the renin-angiotensin system for renal medullary development will be given. Acta Physiologica © 2013 Scandinavian Physiological Society.
OriginalsprogEngelsk
TidsskriftActa Physiologica (Print)
Vol/bind208
Udgave nummer1
Sider (fra-til)41-49
ISSN1748-1708
DOI
StatusUdgivet - 2013

Fingeraftryk

Renin-Angiotensin System
Kidney
Nephrons

Citer dette

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title = "The renin-angiotensin system; development and differentiation of the renal medulla",
abstract = "Adverse events during fetal development can predispose the individual for cardiovascular disease later in life, a correlation known as fetal programming of adult hypertension. The {"}programming{"} events are not known but might reside in the kidneys due to these organs significant role in extracellular volume control and long term blood pressure regulation. Previously, nephron endowment and functional consequences of a low nephron number has been extensively investigated without achieving a full explanation of the underlying pathophysiological mechanisms. In this review, we will focus on mechanisms of postnatal development the renal medulla and putting medullary developmental lesions into perspective with regard to the programming effect. Moreover, the renin-angiotensin system is critically involved in mammalian kidney development and signaling disorders give rise to developmental renal lesions that has been associated with hypertension later in life. A consistent finding in both experimental animal models and in human case reports is atrophy of the renal medulla with developmental lesions to both medullary nephron segments and vascular development with concomitant functional disturbances reaching into adulthood. A review of current knowledge of the role of the renin-angiotensin system for renal medullary development will be given. Acta Physiologica {\circledC} 2013 Scandinavian Physiological Society.",
author = "Kirsten Madsen and {Robdrup Tinning}, Anne and Niels Marcussen and Jensen, {Boye L}",
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The renin-angiotensin system; development and differentiation of the renal medulla. / Madsen, Kirsten; Robdrup Tinning, Anne; Marcussen, Niels; Jensen, Boye L.

I: Acta Physiologica (Print), Bind 208, Nr. 1, 2013, s. 41-49.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The renin-angiotensin system; development and differentiation of the renal medulla

AU - Madsen, Kirsten

AU - Robdrup Tinning, Anne

AU - Marcussen, Niels

AU - Jensen, Boye L

N1 - Acta Physiologica © 2013 Scandinavian Physiological Society.

PY - 2013

Y1 - 2013

N2 - Adverse events during fetal development can predispose the individual for cardiovascular disease later in life, a correlation known as fetal programming of adult hypertension. The "programming" events are not known but might reside in the kidneys due to these organs significant role in extracellular volume control and long term blood pressure regulation. Previously, nephron endowment and functional consequences of a low nephron number has been extensively investigated without achieving a full explanation of the underlying pathophysiological mechanisms. In this review, we will focus on mechanisms of postnatal development the renal medulla and putting medullary developmental lesions into perspective with regard to the programming effect. Moreover, the renin-angiotensin system is critically involved in mammalian kidney development and signaling disorders give rise to developmental renal lesions that has been associated with hypertension later in life. A consistent finding in both experimental animal models and in human case reports is atrophy of the renal medulla with developmental lesions to both medullary nephron segments and vascular development with concomitant functional disturbances reaching into adulthood. A review of current knowledge of the role of the renin-angiotensin system for renal medullary development will be given. Acta Physiologica © 2013 Scandinavian Physiological Society.

AB - Adverse events during fetal development can predispose the individual for cardiovascular disease later in life, a correlation known as fetal programming of adult hypertension. The "programming" events are not known but might reside in the kidneys due to these organs significant role in extracellular volume control and long term blood pressure regulation. Previously, nephron endowment and functional consequences of a low nephron number has been extensively investigated without achieving a full explanation of the underlying pathophysiological mechanisms. In this review, we will focus on mechanisms of postnatal development the renal medulla and putting medullary developmental lesions into perspective with regard to the programming effect. Moreover, the renin-angiotensin system is critically involved in mammalian kidney development and signaling disorders give rise to developmental renal lesions that has been associated with hypertension later in life. A consistent finding in both experimental animal models and in human case reports is atrophy of the renal medulla with developmental lesions to both medullary nephron segments and vascular development with concomitant functional disturbances reaching into adulthood. A review of current knowledge of the role of the renin-angiotensin system for renal medullary development will be given. Acta Physiologica © 2013 Scandinavian Physiological Society.

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DO - 10.1111/apha.12088

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JO - Acta Physiologica (Print)

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