The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

AIM: It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF-A and the MSI status of patients with colorectal cancer (CRC).

METHOD: In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF-A analyses were performed by ELISA.

RESULTS: The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF-A concentration [617 pg/ml (95% CI 445-863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224-386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.

CONCLUSION: This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF-A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti-VEGF-A treatment.

OriginalsprogEngelsk
TidsskriftColorectal Disease Online
Vol/bind13
Udgave nummer9
Sider (fra-til)984-8
Antal sider5
ISSN1463-1318
DOI
StatusUdgivet - sep. 2011

Fingeraftryk

Microsatellite Instability
Vascular Endothelial Growth Factor A
Colorectal Neoplasms
Serum
Neoplasms
Statistical Factor Analysis
Growth

Citer dette

@article{dd160a9e06224b96acb95037237a9492,
title = "The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer",
abstract = "AIM: It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF-A and the MSI status of patients with colorectal cancer (CRC).METHOD: In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF-A analyses were performed by ELISA.RESULTS: The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF-A concentration [617 pg/ml (95{\%} CI 445-863)], compared with patients with an MSS tumour, [317 pg/ml (95{\%} CI 224-386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.CONCLUSION: This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF-A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti-VEGF-A treatment.",
keywords = "Adaptor Proteins, Signal Transducing, Adenocarcinoma, Adenosine Triphosphatases, Adult, Aged, Aged, 80 and over, Colorectal Neoplasms, DNA Repair Enzymes, DNA-Binding Proteins, Female, Humans, Male, Microsatellite Instability, Middle Aged, MutS Homolog 2 Protein, Nuclear Proteins, Vascular Endothelial Growth Factor A",
author = "Hansen, {T F} and Jensen, {L H} and Spindler, {K-L G} and J Lindebjerg and I Brandslund and A Jakobsen",
note = "{\circledC} 2011 The Authors. Colorectal Disease {\circledC} 2011 The Association of Coloproctology of Great Britain and Ireland.",
year = "2011",
month = "9",
doi = "10.1111/j.1463-1318.2010.02357.x",
language = "English",
volume = "13",
pages = "984--8",
journal = "Colorectal Disease",
issn = "1462-8910",
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}

The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer. / Hansen, T F; Jensen, L H; Spindler, K-L G; Lindebjerg, J; Brandslund, I; Jakobsen, A.

I: Colorectal Disease Online, Bind 13, Nr. 9, 09.2011, s. 984-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer

AU - Hansen, T F

AU - Jensen, L H

AU - Spindler, K-L G

AU - Lindebjerg, J

AU - Brandslund, I

AU - Jakobsen, A

N1 - © 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.

PY - 2011/9

Y1 - 2011/9

N2 - AIM: It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF-A and the MSI status of patients with colorectal cancer (CRC).METHOD: In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF-A analyses were performed by ELISA.RESULTS: The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF-A concentration [617 pg/ml (95% CI 445-863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224-386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.CONCLUSION: This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF-A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti-VEGF-A treatment.

AB - AIM: It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF-A and the MSI status of patients with colorectal cancer (CRC).METHOD: In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF-A analyses were performed by ELISA.RESULTS: The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF-A concentration [617 pg/ml (95% CI 445-863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224-386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.CONCLUSION: This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF-A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti-VEGF-A treatment.

KW - Adaptor Proteins, Signal Transducing

KW - Adenocarcinoma

KW - Adenosine Triphosphatases

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colorectal Neoplasms

KW - DNA Repair Enzymes

KW - DNA-Binding Proteins

KW - Female

KW - Humans

KW - Male

KW - Microsatellite Instability

KW - Middle Aged

KW - MutS Homolog 2 Protein

KW - Nuclear Proteins

KW - Vascular Endothelial Growth Factor A

U2 - 10.1111/j.1463-1318.2010.02357.x

DO - 10.1111/j.1463-1318.2010.02357.x

M3 - Journal article

C2 - 20594200

VL - 13

SP - 984

EP - 988

JO - Colorectal Disease

JF - Colorectal Disease

SN - 1462-8910

IS - 9

ER -