The relationship between health-related quality of life, obesity and testosterone levels in older men

Dorte Glintborg, Torben Leo Nielsen, Kristian Wraae, David Hougaard, Claire Gudex, Kim Brixen, Marianne Andersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Background: Quality of life evaluated by Short-Form 36 (SF-36) is decreased in obesity and hypogonadism, but the importance of regional fat mass is unknown. In the present study, we evaluated associations between SF-36, regional fat deposits and bioavailable testosterone (BioT) in ageing men. Methods: A population-based cross-sectional study in older men. Data included SF-36 questionnaires with the dimensions such as physical function, role limitations physical, bodily pain, general health, vitality, social function, role limitations emotional and mental health. Furthermore, waist, lean body mass (measured by dual X-ray absorptiometry), visceral adipose tissue and subcutaneous adipose tissue (SAT) (measured by magnetic resonance imaging) and BioT were established. Results: Five hundred and ninety-eight men aged 60-74 years were included. The SF-36 dimensions such as physical function, general health, vitality and role limitations functional were inversely associated with waist and SAT and positively associated with BioT. In multiple regression analysis, waist was the body composition measure with the strongest association with SF-36 dimension scores. Conclusion: SF-36 dimension scores were more closely associated with central obesity than with BioT. Clinical trial registration number: www.clinicaltrials.gov, NCT00155961.

OriginalsprogEngelsk
Artikelnummeraft203
TidsskriftAge and Ageing
Vol/bind43
Udgave nummer2
Sider (fra-til)280-284
ISSN1468-2834
DOI
StatusUdgivet - mar. 2014

Bibliografisk note

E-pub ahead of print

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