The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

J Giebelstein; G Poschmann; K Højlund; W Schechinger; J W Dietrich; K Levin; H Beck-Nielsen; K Podwojski; K Stühler; H E Meyer; H H Klein

doi:10.1007/s00125-012-2456-x

The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

J Giebelstein
, G Poschmann
, K Højlund
, W Schechinger
, J W Dietrich
, K Levin
, H Beck-Nielsen
, K Podwojski
, K Stühler
, H E Meyer
, H H Klein

KI, OUH, Forskningsenhed for Endokrinologi (Odense)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	4
Sider (fra-til)	1114-27
Antal sider	14
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-012-2456-x
Status	Udgivet - 2012

Dokumenter og links

10.1007/s00125-012-2456-x

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Giebelstein, J., Poschmann, G., Højlund, K., Schechinger, W., Dietrich, J. W., Levin, K., Beck-Nielsen, H., Podwojski, K., Stühler, K., Meyer, H. E., & Klein, H. H. (2012). The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes. Diabetologia, 55(4), 1114-27. https://doi.org/10.1007/s00125-012-2456-x

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abstract = "The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.",

keywords = "Diabetes Mellitus, Type 2, Female, Glucose Clamp Technique, Glycolysis, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Skeletal, Obesity, Proteomics, Tandem Mass Spectrometry",

author = "J Giebelstein and G Poschmann and K H{\o}jlund and W Schechinger and Dietrich, \{J W\} and K Levin and H Beck-Nielsen and K Podwojski and K St{\"u}hler and Meyer, \{H E\} and Klein, \{H H\}",

year = "2012",

doi = "10.1007/s00125-012-2456-x",

language = "English",

volume = "55",

pages = "1114--27",

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Giebelstein, J, Poschmann, G, Højlund, K, Schechinger, W, Dietrich, JW, Levin, K, Beck-Nielsen, H, Podwojski, K, Stühler, K, Meyer, HE & Klein, HH 2012, 'The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes', Diabetologia, bind 55, nr. 4, s. 1114-27. https://doi.org/10.1007/s00125-012-2456-x

TY - JOUR

T1 - The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

AU - Giebelstein, J

AU - Poschmann, G

AU - Højlund, K

AU - Schechinger, W

AU - Dietrich, J W

AU - Levin, K

AU - Beck-Nielsen, H

AU - Podwojski, K

AU - Stühler, K

AU - Meyer, H E

AU - Klein, H H

PY - 2012

Y1 - 2012

N2 - The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.

AB - The molecular mechanisms underlying insulin resistance in skeletal muscle are incompletely understood. Here, we aimed to obtain a global picture of changes in protein abundance in skeletal muscle in obesity and type 2 diabetes, and those associated with whole-body measures of insulin action.

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucose Clamp Technique

KW - Glycolysis

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Mitochondria

KW - Muscle, Skeletal

KW - Obesity

KW - Proteomics

KW - Tandem Mass Spectrometry

U2 - 10.1007/s00125-012-2456-x

DO - 10.1007/s00125-012-2456-x

M3 - Journal article

C2 - 22282162

SN - 0012-186X

VL - 55

SP - 1114

EP - 1127

JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

Abstract

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater