The prognostic and predictive value of combined HE4 and CA-125 in ovarian cancer patients

Karina Dahl Steffensen; Marianne Waldstrøm; Ivan Brandslund; Max Petzold; Anders Jakobsen

doi:10.1097/IGC.0b013e3182681cfd

The prognostic and predictive value of combined HE4 and CA-125 in ovarian cancer patients

Karina Dahl Steffensen
, Marianne Waldstrøm
, Ivan Brandslund
, Max Petzold
, Anders Jakobsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

A risk-of-ovarian-malignancy algorithm (ROMA) based on human epididymis protein 4 (HE4) and CA-125 has been reported to categorize women with a pelvic mass into high or low risk of ovarian malignancy. Originally, the ROMA score was developed for diagnostic purposes and the clinical application of HE4 for other purposes such as a predictor of survival or platinum resistance has not been extensively investigated. The objective of the present study was to evaluate the prognostic importance of prechemotherapy combined levels of HE4 and CA-125 and prediction of platinum resistance. Furthermore, we wanted to investigate the dynamics of the markers during treatment.

Originalsprog	Engelsk
Tidsskrift	International Journal of Gynecological Cancer
Vol/bind	22
Udgave nummer	9
Sider (fra-til)	1474-1482
ISSN	1048-891X
DOI	https://doi.org/10.1097/IGC.0b013e3182681cfd
Status	Udgivet - 2012

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10.1097/IGC.0b013e3182681cfd

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abstract = "A risk-of-ovarian-malignancy algorithm (ROMA) based on human epididymis protein 4 (HE4) and CA-125 has been reported to categorize women with a pelvic mass into high or low risk of ovarian malignancy. Originally, the ROMA score was developed for diagnostic purposes and the clinical application of HE4 for other purposes such as a predictor of survival or platinum resistance has not been extensively investigated. The objective of the present study was to evaluate the prognostic importance of prechemotherapy combined levels of HE4 and CA-125 and prediction of platinum resistance. Furthermore, we wanted to investigate the dynamics of the markers during treatment.",

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T1 - The prognostic and predictive value of combined HE4 and CA-125 in ovarian cancer patients

AU - Steffensen, Karina Dahl

AU - Waldstrøm, Marianne

AU - Brandslund, Ivan

AU - Petzold, Max

AU - Jakobsen, Anders

PY - 2012

Y1 - 2012

N2 - A risk-of-ovarian-malignancy algorithm (ROMA) based on human epididymis protein 4 (HE4) and CA-125 has been reported to categorize women with a pelvic mass into high or low risk of ovarian malignancy. Originally, the ROMA score was developed for diagnostic purposes and the clinical application of HE4 for other purposes such as a predictor of survival or platinum resistance has not been extensively investigated. The objective of the present study was to evaluate the prognostic importance of prechemotherapy combined levels of HE4 and CA-125 and prediction of platinum resistance. Furthermore, we wanted to investigate the dynamics of the markers during treatment.

AB - A risk-of-ovarian-malignancy algorithm (ROMA) based on human epididymis protein 4 (HE4) and CA-125 has been reported to categorize women with a pelvic mass into high or low risk of ovarian malignancy. Originally, the ROMA score was developed for diagnostic purposes and the clinical application of HE4 for other purposes such as a predictor of survival or platinum resistance has not been extensively investigated. The objective of the present study was to evaluate the prognostic importance of prechemotherapy combined levels of HE4 and CA-125 and prediction of platinum resistance. Furthermore, we wanted to investigate the dynamics of the markers during treatment.

U2 - 10.1097/IGC.0b013e3182681cfd

DO - 10.1097/IGC.0b013e3182681cfd

M3 - Journal article

C2 - 23095772

SN - 1048-891X

VL - 22

SP - 1474

EP - 1482

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

IS - 9

ER -

The prognostic and predictive value of combined HE4 and CA-125 in ovarian cancer patients

Abstract

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