The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

Vibeke Andersen*, Anja Ernst, Jane Hvarregaard Christensen, Mette Faurholt Østergaard, Bent Ascanius Jacobsen, Anne Tjønneland, Henrik Bygum Krarup, Ulla Birgitte Vogel

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Abstrakt

Crohn's disease (CD) and ulcerative colitis (UC) are characterized by a dysregulated inflammatory response to normal constituents of the intestinal flora in the genetically predisposed host. Heme oxygenase-1 (HO-1/HMOX1) is a powerful anti-inflammatory and anti-oxidant enzyme, whereas the pro-inflammatory interleukin 1 beta (IL-1 beta/IL1B) and anti-inflammatory interleukin 10 (IL-10/IL10) are key modulators for the initiation and maintenance of inflammation. We investigated whether single nucleotide polymorphisms (SNPs) in the IL-1 beta, IL-10, and HO-1 genes, together with smoking, were associated with risk of CD and UC.
OriginalsprogEngelsk
Artikelnummer82
TidsskriftB M C Medical Genetics
Vol/bind11
Antal sider10
ISSN1471-2350
DOI
StatusUdgivet - 28. maj 2010
Udgivet eksterntJa

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