The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study

Thomas H Brix; Pia S Hansen; Kirsten O Kyvik; Laszlo Hegedüs

doi:10.1111/j.1365-2265.2010.03848.x

The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study

Thomas H Brix, Pia S Hansen, Kirsten O Kyvik, Laszlo Hegedüs

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstrakt

The pituitary-thyroid axis (PTA) set point is determined by a combination of genetic and environmental factors. However, despite considerable efforts to characterize the background, the causative genes as well as environmental factors are not well established. Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women.

Originalsprog	Engelsk
Tidsskrift	Clinical Endocrinology
Vol/bind	73
Udgave nummer	5
Sider (fra-til)	666-70
Antal sider	5
ISSN	0300-0664
DOI	https://doi.org/10.1111/j.1365-2265.2010.03848.x
Status	Udgivet - 1. nov. 2010

Fingerprint

Citationsformater

Brix, T. H., Hansen, P. S., Kyvik, K. O., & Hegedüs, L. (2010). The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study. Clinical Endocrinology, 73(5), 666-70. https://doi.org/10.1111/j.1365-2265.2010.03848.x

@article{f24405fcd3814ca1896aca3ef3a3d7a0,

title = "The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study",

abstract = "The pituitary-thyroid axis (PTA) set point is determined by a combination of genetic and environmental factors. However, despite considerable efforts to characterize the background, the causative genes as well as environmental factors are not well established. Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women.",

author = "Brix, {Thomas H} and Hansen, {Pia S} and Kyvik, {Kirsten O} and Laszlo Heged{\"u}s",

note = "{\textcopyright} 2010 Blackwell Publishing Ltd.",

year = "2010",

month = nov

day = "1",

doi = "10.1111/j.1365-2265.2010.03848.x",

language = "English",

volume = "73",

pages = "666--70",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study

AU - Brix, Thomas H

AU - Hansen, Pia S

AU - Kyvik, Kirsten O

AU - Hegedüs, Laszlo

PY - 2010/11/1

Y1 - 2010/11/1

N2 - The pituitary-thyroid axis (PTA) set point is determined by a combination of genetic and environmental factors. However, despite considerable efforts to characterize the background, the causative genes as well as environmental factors are not well established. Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women.

AB - The pituitary-thyroid axis (PTA) set point is determined by a combination of genetic and environmental factors. However, despite considerable efforts to characterize the background, the causative genes as well as environmental factors are not well established. Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women.

U2 - 10.1111/j.1365-2265.2010.03848.x

DO - 10.1111/j.1365-2265.2010.03848.x

M3 - Journal article

C2 - 20718768

VL - 73

SP - 666

EP - 670

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 5

ER -

Dokumenter og links

10.1111/j.1365-2265.2010.03848.x

https://hal.archives-ouvertes.fr/hal-00583580/document