The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study

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Abstrakt

The pituitary-thyroid axis (PTA) set point is determined by a combination of genetic and environmental factors. However, despite considerable efforts to characterize the background, the causative genes as well as environmental factors are not well established. Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women.
OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind73
Udgave nummer5
Sider (fra-til)666-70
Antal sider5
ISSN0300-0664
DOI
StatusUdgivet - 1. nov. 2010

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