The peri-operative cytokine response in infants and young children following major surgery

Tom Giedsing Hansen, Else Kirstine Tønnesen, J B Andersen, P Toft, Klaus Bendtzen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The peri-operative cytokine response was studied in 13 infants and young children undergoing major surgery. All children were anaesthetized with a combined general and epidural anaesthetic technique, followed by post-operative epidural analgesia with bupivacaine and fentanyl. Blood samples were taken before and after surgery, 24 h post-operatively, and finally, when the children were mobilized and had regained gastrointestinal function. Plasma samples were analysed for tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interferon-gamma, interleukin-10 and the interleukin-1 receptor antagonist. The cytokine responses were highly variable. Overall, no significant changes between pre- and post-operative plasma concentrations were found. Tumour necrosis factor-alpha and the interleukin-1 receptor antagonist were detectable in all children, and a trend towards an early increase in the interleukin-1 receptor antagonist levels at the end of surgery was seen. The other cytokines were only detectable at low concentrations among a minority of children. In conclusion, this study showed highly variable peri-operative cytokine responses in infants and young children undergoing major surgery.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Anaesthesiology
Vol/bind15
Udgave nummer1
Sider (fra-til)56-60
Antal sider5
ISSN0265-0215
StatusUdgivet - 1998

Fingeraftryk

Interleukin-1 Receptors
Combined Anesthetics
Tumor Necrosis Factor-alpha
Post and Core Technique
Interleukin-1alpha
Epidural Analgesia
Fentanyl
Interleukin-1beta
Interleukin-10
Interferon-gamma
Interleukin-6

Citer dette

Hansen, Tom Giedsing ; Tønnesen, Else Kirstine ; Andersen, J B ; Toft, P ; Bendtzen, Klaus. / The peri-operative cytokine response in infants and young children following major surgery. I: European Journal of Anaesthesiology. 1998 ; Bind 15, Nr. 1. s. 56-60.
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abstract = "The peri-operative cytokine response was studied in 13 infants and young children undergoing major surgery. All children were anaesthetized with a combined general and epidural anaesthetic technique, followed by post-operative epidural analgesia with bupivacaine and fentanyl. Blood samples were taken before and after surgery, 24 h post-operatively, and finally, when the children were mobilized and had regained gastrointestinal function. Plasma samples were analysed for tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interferon-gamma, interleukin-10 and the interleukin-1 receptor antagonist. The cytokine responses were highly variable. Overall, no significant changes between pre- and post-operative plasma concentrations were found. Tumour necrosis factor-alpha and the interleukin-1 receptor antagonist were detectable in all children, and a trend towards an early increase in the interleukin-1 receptor antagonist levels at the end of surgery was seen. The other cytokines were only detectable at low concentrations among a minority of children. In conclusion, this study showed highly variable peri-operative cytokine responses in infants and young children undergoing major surgery.",
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The peri-operative cytokine response in infants and young children following major surgery. / Hansen, Tom Giedsing; Tønnesen, Else Kirstine; Andersen, J B; Toft, P; Bendtzen, Klaus.

I: European Journal of Anaesthesiology, Bind 15, Nr. 1, 1998, s. 56-60.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The peri-operative cytokine response in infants and young children following major surgery

AU - Hansen, Tom Giedsing

AU - Tønnesen, Else Kirstine

AU - Andersen, J B

AU - Toft, P

AU - Bendtzen, Klaus

PY - 1998

Y1 - 1998

N2 - The peri-operative cytokine response was studied in 13 infants and young children undergoing major surgery. All children were anaesthetized with a combined general and epidural anaesthetic technique, followed by post-operative epidural analgesia with bupivacaine and fentanyl. Blood samples were taken before and after surgery, 24 h post-operatively, and finally, when the children were mobilized and had regained gastrointestinal function. Plasma samples were analysed for tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interferon-gamma, interleukin-10 and the interleukin-1 receptor antagonist. The cytokine responses were highly variable. Overall, no significant changes between pre- and post-operative plasma concentrations were found. Tumour necrosis factor-alpha and the interleukin-1 receptor antagonist were detectable in all children, and a trend towards an early increase in the interleukin-1 receptor antagonist levels at the end of surgery was seen. The other cytokines were only detectable at low concentrations among a minority of children. In conclusion, this study showed highly variable peri-operative cytokine responses in infants and young children undergoing major surgery.

AB - The peri-operative cytokine response was studied in 13 infants and young children undergoing major surgery. All children were anaesthetized with a combined general and epidural anaesthetic technique, followed by post-operative epidural analgesia with bupivacaine and fentanyl. Blood samples were taken before and after surgery, 24 h post-operatively, and finally, when the children were mobilized and had regained gastrointestinal function. Plasma samples were analysed for tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interferon-gamma, interleukin-10 and the interleukin-1 receptor antagonist. The cytokine responses were highly variable. Overall, no significant changes between pre- and post-operative plasma concentrations were found. Tumour necrosis factor-alpha and the interleukin-1 receptor antagonist were detectable in all children, and a trend towards an early increase in the interleukin-1 receptor antagonist levels at the end of surgery was seen. The other cytokines were only detectable at low concentrations among a minority of children. In conclusion, this study showed highly variable peri-operative cytokine responses in infants and young children undergoing major surgery.

KW - Anesthesia, Epidural

KW - Anesthesia, General

KW - Child, Preschool

KW - Cytokines

KW - Female

KW - Humans

KW - Infant

KW - Interleukins

KW - Intraoperative Period

KW - Male

KW - Postoperative Period

KW - Tumor Necrosis Factor-alpha

M3 - Journal article

C2 - 9522142

VL - 15

SP - 56

EP - 60

JO - European Journal of Anaesthesiology

JF - European Journal of Anaesthesiology

SN - 0265-0215

IS - 1

ER -