The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes

Rikke Riber-Hansen, Jens Nyengaard, Stephen Hamilton-Dutoit, Torben Steiniche

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Jul-28
OriginalsprogEngelsk
TidsskriftAmerican Journal of Surgical Pathology
Vol/bind33
Udgave nummer10
Sider (fra-til)1522-1528
Antal sider7
ISSN0147-5185
DOI
StatusUdgivet - 28. jul. 2009

Fingeraftryk

Melanoma

Citer dette

Riber-Hansen, R., Nyengaard, J., Hamilton-Dutoit, S., & Steiniche, T. (2009). The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes. American Journal of Surgical Pathology, 33(10), 1522-1528. https://doi.org/10.1097/PAS.0b013e3181b0bd4f
Riber-Hansen, Rikke ; Nyengaard, Jens ; Hamilton-Dutoit, Stephen ; Steiniche, Torben. / The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes. I: American Journal of Surgical Pathology. 2009 ; Bind 33, Nr. 10. s. 1522-1528.
@article{e5255e20e4f711deaefb000ea68e967b,
title = "The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes",
abstract = "BACKGROUND: The design of melanoma sentinel lymph node (SLN) histologic protocols is based on the premise that most metastases are found in the central parts of the nodes, but the evidence for this belief has never been thoroughly tested. METHODS: The nodal location of melanoma metastases in 149 prospectively analyzed, completely step sectioned, positive SLNs from 96 patients was examined using 3 theoretical protocols, evaluating respectively: (1) the 3 most central step sections only; (2) the 3 most peripheral step sections only; and (3) 3 step sections evenly distributed throughout the individual SLNs. In addition, the size of the metastases located exclusively outside the 2 regional protocols (ie, 3 central sections, and 3 peripheral sections) were measured and compared with each other. RESULTS: The metastasis detection rates of the central, the peripheral, and the evenly distributed protocols were 77{\%}, 79{\%}, and 78{\%}, respectively. No difference in either the mean volume or the maximum diameter of the metastases located exclusively outside the central and the peripheral protocols was found (volume: 0.036 vs. 0.031 mm and diameter: 0.320 vs. 0.332 mm). CONCLUSIONS: In SLNs, melanoma metastases are located throughout the nodes. Metastases located exclusively outside the peripheral or the central protocol are equally sized. Complete step sectioning of all SLNs will ensure both high metastasis detection rates and detection of all large metastases, and allow for performance of unbiased size estimates.",
author = "Rikke Riber-Hansen and Jens Nyengaard and Stephen Hamilton-Dutoit and Torben Steiniche",
year = "2009",
month = "7",
day = "28",
doi = "10.1097/PAS.0b013e3181b0bd4f",
language = "English",
volume = "33",
pages = "1522--1528",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams & Wilkins",
number = "10",

}

Riber-Hansen, R, Nyengaard, J, Hamilton-Dutoit, S & Steiniche, T 2009, 'The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes', American Journal of Surgical Pathology, bind 33, nr. 10, s. 1522-1528. https://doi.org/10.1097/PAS.0b013e3181b0bd4f

The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes. / Riber-Hansen, Rikke; Nyengaard, Jens; Hamilton-Dutoit, Stephen; Steiniche, Torben.

I: American Journal of Surgical Pathology, Bind 33, Nr. 10, 28.07.2009, s. 1522-1528.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes

AU - Riber-Hansen, Rikke

AU - Nyengaard, Jens

AU - Hamilton-Dutoit, Stephen

AU - Steiniche, Torben

PY - 2009/7/28

Y1 - 2009/7/28

N2 - BACKGROUND: The design of melanoma sentinel lymph node (SLN) histologic protocols is based on the premise that most metastases are found in the central parts of the nodes, but the evidence for this belief has never been thoroughly tested. METHODS: The nodal location of melanoma metastases in 149 prospectively analyzed, completely step sectioned, positive SLNs from 96 patients was examined using 3 theoretical protocols, evaluating respectively: (1) the 3 most central step sections only; (2) the 3 most peripheral step sections only; and (3) 3 step sections evenly distributed throughout the individual SLNs. In addition, the size of the metastases located exclusively outside the 2 regional protocols (ie, 3 central sections, and 3 peripheral sections) were measured and compared with each other. RESULTS: The metastasis detection rates of the central, the peripheral, and the evenly distributed protocols were 77%, 79%, and 78%, respectively. No difference in either the mean volume or the maximum diameter of the metastases located exclusively outside the central and the peripheral protocols was found (volume: 0.036 vs. 0.031 mm and diameter: 0.320 vs. 0.332 mm). CONCLUSIONS: In SLNs, melanoma metastases are located throughout the nodes. Metastases located exclusively outside the peripheral or the central protocol are equally sized. Complete step sectioning of all SLNs will ensure both high metastasis detection rates and detection of all large metastases, and allow for performance of unbiased size estimates.

AB - BACKGROUND: The design of melanoma sentinel lymph node (SLN) histologic protocols is based on the premise that most metastases are found in the central parts of the nodes, but the evidence for this belief has never been thoroughly tested. METHODS: The nodal location of melanoma metastases in 149 prospectively analyzed, completely step sectioned, positive SLNs from 96 patients was examined using 3 theoretical protocols, evaluating respectively: (1) the 3 most central step sections only; (2) the 3 most peripheral step sections only; and (3) 3 step sections evenly distributed throughout the individual SLNs. In addition, the size of the metastases located exclusively outside the 2 regional protocols (ie, 3 central sections, and 3 peripheral sections) were measured and compared with each other. RESULTS: The metastasis detection rates of the central, the peripheral, and the evenly distributed protocols were 77%, 79%, and 78%, respectively. No difference in either the mean volume or the maximum diameter of the metastases located exclusively outside the central and the peripheral protocols was found (volume: 0.036 vs. 0.031 mm and diameter: 0.320 vs. 0.332 mm). CONCLUSIONS: In SLNs, melanoma metastases are located throughout the nodes. Metastases located exclusively outside the peripheral or the central protocol are equally sized. Complete step sectioning of all SLNs will ensure both high metastasis detection rates and detection of all large metastases, and allow for performance of unbiased size estimates.

U2 - 10.1097/PAS.0b013e3181b0bd4f

DO - 10.1097/PAS.0b013e3181b0bd4f

M3 - Journal article

VL - 33

SP - 1522

EP - 1528

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 10

ER -