The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma

Itziar Urizar-Arenaza*, Aitor Benedicto, Arantza Perez-Valle, Nerea Osinalde, Vyacheslav Akimov, Iraia Muñoa-Hoyos, Jose Antonio Rodriguez, Aintzane Asumendi, Maria Dolores Boyano, Blagoy Blagoev, Irina Kratchmarova, Nerea Subiran

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Abstrakt

Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melanoma cells, but their contribution to cancer development and the underlying molecular mechanisms of skin tumourigenesis remain unknown. Combining functional and proteomic approaches, the present work describes the presence of SPANX-A/D in primary and metastatic human melanoma cells and how it promotes pro-tumoural processes such as cell proliferation, motility and migration. We provide insights into the molecular features of skin tumourigenesis, describing for the first time a multifunctional role of the SPANX-A/D protein family in nuclear function, energy metabolism and cell survival, considered key hallmarks of cancer. A better comprehension of the SPANX-A/D protein subfamily and its molecular mechanisms will help to describe new aspects of tumour cell biology and develop new therapeutic targets and tumour-directed pharmacological drugs for skin tumours.

OriginalsprogEngelsk
Artikelnummer3583
TidsskriftScientific Reports
Vol/bind11
Antal sider12
ISSN2045-2322
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Publisher Copyright:
© 2021, The Author(s).

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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