TY - JOUR
T1 - The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma
AU - Urizar-Arenaza, Itziar
AU - Benedicto, Aitor
AU - Perez-Valle, Arantza
AU - Osinalde, Nerea
AU - Akimov, Vyacheslav
AU - Muñoa-Hoyos, Iraia
AU - Rodriguez, Jose Antonio
AU - Asumendi, Aintzane
AU - Boyano, Maria Dolores
AU - Blagoev, Blagoy
AU - Kratchmarova, Irina
AU - Subiran, Nerea
N1 - Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melanoma cells, but their contribution to cancer development and the underlying molecular mechanisms of skin tumourigenesis remain unknown. Combining functional and proteomic approaches, the present work describes the presence of SPANX-A/D in primary and metastatic human melanoma cells and how it promotes pro-tumoural processes such as cell proliferation, motility and migration. We provide insights into the molecular features of skin tumourigenesis, describing for the first time a multifunctional role of the SPANX-A/D protein family in nuclear function, energy metabolism and cell survival, considered key hallmarks of cancer. A better comprehension of the SPANX-A/D protein subfamily and its molecular mechanisms will help to describe new aspects of tumour cell biology and develop new therapeutic targets and tumour-directed pharmacological drugs for skin tumours.
AB - Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various tumour cells. SPANX-A/D proteins have been detected in metastatic melanoma cells, but their contribution to cancer development and the underlying molecular mechanisms of skin tumourigenesis remain unknown. Combining functional and proteomic approaches, the present work describes the presence of SPANX-A/D in primary and metastatic human melanoma cells and how it promotes pro-tumoural processes such as cell proliferation, motility and migration. We provide insights into the molecular features of skin tumourigenesis, describing for the first time a multifunctional role of the SPANX-A/D protein family in nuclear function, energy metabolism and cell survival, considered key hallmarks of cancer. A better comprehension of the SPANX-A/D protein subfamily and its molecular mechanisms will help to describe new aspects of tumour cell biology and develop new therapeutic targets and tumour-directed pharmacological drugs for skin tumours.
U2 - 10.1038/s41598-021-83169-1
DO - 10.1038/s41598-021-83169-1
M3 - Journal article
C2 - 33574425
AN - SCOPUS:85100734649
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
M1 - 3583
ER -