The major histocompatibility complex in the chicken.

F Guillemot, J F Kaufman, K Skjoedt, C Auffray

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The chicken B complex is the first non-mammalian MHC characterized at the molecular level. It differs from the human HLA and murine H-2 complexes in the small size of the class I (B-F) and class II (B-L) genes and their close proximity. This proximity accounts for the absence of recombination between B-F and B-L genes and leaves no space for class III genes. Moreover the B-F and B-L genes are tightly linked to unrelated genes absent from mammalian MHCs, such as the polymorphic B-G genes and a member of the G protein beta subunit family. This linkage could form the basis for resistance to viral-induced tumors associated with some B complex haplotypes.
Udgivelsesdato: 1989-Sep
TidsskriftTrends in Genetics
Udgave nummer9
Sider (fra-til)300-4
Antal sider4
StatusUdgivet - 1. sep. 1989