The interrelation between hypothyroidism and glaucoma: A critical review and meta-analysis

M. Thvilum, Frans Hjelm Brandt Kristensen, T. H. Brix, L. Hegedus

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Resumé

The literature reports conflicting results on the association between hypothyroidism and glaucoma. We sought to clarify this by conducting a critical review and meta-analyses. Based on an electronic PubMed search, using the Medical Subject Heading terms hypothyroidism, myxoedema and glaucoma or intra ocular pressure, case-control studies, cohort studies and cross sectional studies were identified and reviewed. Using meta-analysis, the relative risk (RR) of co-existence of glaucoma and hypothyroidism was calculated. 12 studies fulfilled the inclusion criteria and could be categorized into two groups based on the exposure. The group with glaucoma (5679 patients) as exposure and hypothyroidism as outcome comprised eight studies. Among these, we found a non-significantly increased risk of hypothyroidism associated with glaucoma (RR 1.65; 95% confidence interval [CI]: 0.97-2.82). Based on 4 studies (165,980 patients) with hypothyroidism as exposure and glaucoma as outcome, we found the risk of glaucoma to be significantly increased (RR 1.39; 95% CI: 1.08-1.78). Based on these meta-analyses, there seems to be an association between hypothyroidism and glaucoma. However, larger scale studies with better phenotype classifications, longer follow-up time and taking co-morbidity and other biases into consideration are needed to address a potential causal relationship.
OriginalsprogEngelsk
Artikelnummer558
TidsskriftThyroid
Vol/bind25
Udgave nummerS1
Sider (fra-til)A222-A223
ISSN1050-7256
DOI
StatusUdgivet - 2015
BegivenhedInternational Thyroid Congress - Walt Disney World Swan and Dolphin Resort, Orlando, USA
Varighed: 18. okt. 201523. okt. 2015

Konference

KonferenceInternational Thyroid Congress
LokationWalt Disney World Swan and Dolphin Resort
LandUSA
ByOrlando
Periode18/10/201523/10/2015

Emneord

  • *thyroid gland *glaucoma *meta analysis *hypothyroidism *American exposure human patient risk intraocular pressure cross- sectional study cohort analysis myxedema morbidity risk factor Medical Subject Headings follow up confidence interval case control study classification phenotype Medline

Citer dette

@article{d37a940eb357430294b2d1252a93a890,
title = "The interrelation between hypothyroidism and glaucoma: A critical review and meta-analysis",
abstract = "The literature reports conflicting results on the association between hypothyroidism and glaucoma. We sought to clarify this by conducting a critical review and meta-analyses. Based on an electronic PubMed search, using the Medical Subject Heading terms hypothyroidism, myxoedema and glaucoma or intra ocular pressure, case-control studies, cohort studies and cross sectional studies were identified and reviewed. Using meta-analysis, the relative risk (RR) of co-existence of glaucoma and hypothyroidism was calculated. 12 studies fulfilled the inclusion criteria and could be categorized into two groups based on the exposure. The group with glaucoma (5679 patients) as exposure and hypothyroidism as outcome comprised eight studies. Among these, we found a non-significantly increased risk of hypothyroidism associated with glaucoma (RR 1.65; 95{\%} confidence interval [CI]: 0.97-2.82). Based on 4 studies (165,980 patients) with hypothyroidism as exposure and glaucoma as outcome, we found the risk of glaucoma to be significantly increased (RR 1.39; 95{\%} CI: 1.08-1.78). Based on these meta-analyses, there seems to be an association between hypothyroidism and glaucoma. However, larger scale studies with better phenotype classifications, longer follow-up time and taking co-morbidity and other biases into consideration are needed to address a potential causal relationship.",
keywords = "*thyroid gland *glaucoma *meta analysis *hypothyroidism *American exposure human patient risk intraocular pressure cross- sectional study cohort analysis myxedema morbidity risk factor Medical Subject Headings follow up confidence interval case control study classification phenotype Medline",
author = "M. Thvilum and {Hjelm Brandt Kristensen}, Frans and Brix, {T. H.} and L. Hegedus",
year = "2015",
doi = "10.1089/thy.2015.29004.abstracts",
language = "English",
volume = "25",
pages = "A222--A223",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann Liebert Incorporated",
number = "S1",

}

The interrelation between hypothyroidism and glaucoma : A critical review and meta-analysis. / Thvilum, M.; Hjelm Brandt Kristensen, Frans; Brix, T. H.; Hegedus, L.

I: Thyroid, Bind 25, Nr. S1, 558, 2015, s. A222-A223.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

TY - ABST

T1 - The interrelation between hypothyroidism and glaucoma

T2 - A critical review and meta-analysis

AU - Thvilum, M.

AU - Hjelm Brandt Kristensen, Frans

AU - Brix, T. H.

AU - Hegedus, L.

PY - 2015

Y1 - 2015

N2 - The literature reports conflicting results on the association between hypothyroidism and glaucoma. We sought to clarify this by conducting a critical review and meta-analyses. Based on an electronic PubMed search, using the Medical Subject Heading terms hypothyroidism, myxoedema and glaucoma or intra ocular pressure, case-control studies, cohort studies and cross sectional studies were identified and reviewed. Using meta-analysis, the relative risk (RR) of co-existence of glaucoma and hypothyroidism was calculated. 12 studies fulfilled the inclusion criteria and could be categorized into two groups based on the exposure. The group with glaucoma (5679 patients) as exposure and hypothyroidism as outcome comprised eight studies. Among these, we found a non-significantly increased risk of hypothyroidism associated with glaucoma (RR 1.65; 95% confidence interval [CI]: 0.97-2.82). Based on 4 studies (165,980 patients) with hypothyroidism as exposure and glaucoma as outcome, we found the risk of glaucoma to be significantly increased (RR 1.39; 95% CI: 1.08-1.78). Based on these meta-analyses, there seems to be an association between hypothyroidism and glaucoma. However, larger scale studies with better phenotype classifications, longer follow-up time and taking co-morbidity and other biases into consideration are needed to address a potential causal relationship.

AB - The literature reports conflicting results on the association between hypothyroidism and glaucoma. We sought to clarify this by conducting a critical review and meta-analyses. Based on an electronic PubMed search, using the Medical Subject Heading terms hypothyroidism, myxoedema and glaucoma or intra ocular pressure, case-control studies, cohort studies and cross sectional studies were identified and reviewed. Using meta-analysis, the relative risk (RR) of co-existence of glaucoma and hypothyroidism was calculated. 12 studies fulfilled the inclusion criteria and could be categorized into two groups based on the exposure. The group with glaucoma (5679 patients) as exposure and hypothyroidism as outcome comprised eight studies. Among these, we found a non-significantly increased risk of hypothyroidism associated with glaucoma (RR 1.65; 95% confidence interval [CI]: 0.97-2.82). Based on 4 studies (165,980 patients) with hypothyroidism as exposure and glaucoma as outcome, we found the risk of glaucoma to be significantly increased (RR 1.39; 95% CI: 1.08-1.78). Based on these meta-analyses, there seems to be an association between hypothyroidism and glaucoma. However, larger scale studies with better phenotype classifications, longer follow-up time and taking co-morbidity and other biases into consideration are needed to address a potential causal relationship.

KW - thyroid gland glaucoma meta analysis hypothyroidism American exposure human patient risk intraocular pressure cross- sectional study cohort analysis myxedema morbidity risk factor Medical Subject Headings follow up confidence interval case control study c

U2 - 10.1089/thy.2015.29004.abstracts

DO - 10.1089/thy.2015.29004.abstracts

M3 - Conference abstract in journal

VL - 25

SP - A222-A223

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - S1

M1 - 558

ER -