The influence of desipramine on thyroid hormone metabolism in rat brain

A Campos-Barros, H Meinhold, M Stula, F Müller, R Köhler, M Eravci, O Putzien, A Baumgartner

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 1994-Mar
OriginalsprogEngelsk
TidsskriftJournal of Pharmacology and Experimental Therapeutics
Vol/bind268
Udgave nummer3
Sider (fra-til)1143-52
Antal sider9
ISSN0022-3565
StatusUdgivet - 1. mar. 1994
Udgivet eksterntJa

Fingeraftryk

Desipramine
Iodide Peroxidase
Locus Coeruleus
Photoperiod
Circadian Rhythm
Isoenzymes
Enzymes
Serum

Citer dette

Campos-Barros, A., Meinhold, H., Stula, M., Müller, F., Köhler, R., Eravci, M., ... Baumgartner, A. (1994). The influence of desipramine on thyroid hormone metabolism in rat brain. Journal of Pharmacology and Experimental Therapeutics, 268(3), 1143-52.
Campos-Barros, A ; Meinhold, H ; Stula, M ; Müller, F ; Köhler, R ; Eravci, M ; Putzien, O ; Baumgartner, A. / The influence of desipramine on thyroid hormone metabolism in rat brain. I: Journal of Pharmacology and Experimental Therapeutics. 1994 ; Bind 268, Nr. 3. s. 1143-52.
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title = "The influence of desipramine on thyroid hormone metabolism in rat brain",
abstract = "The effect of the antidepressant desipramine (DMI) on the activities of the three iodothyronine deiodinase isoenzymes involved in the central metabolism of thyroid hormones were investigated in 11 brain regions and 3 peripheral tissues in the rat. The investigations were carried out at three different times during the light/dark cycle: 5 A.M., 1 P.M. and 11 P.M. Interest is focused on changes in the two enzymes that catalyze: i) the 5'deiodination of T4 to the biologically active T3, i.e., type II 5'deiodinase (5'D-II), and ii) the 5 (or inner-ring) deiodination of T3 to the biologically inactive 3,3'T2, i.e., type III 5 deiodinase (5D-III). Fourteen days' treatment with 20 mg/kg DMI, but not with 5 mg/kg DMI, induced significant increases in 5'D-II in eight different areas of the CNS. The regions affected were identical to those that receive noradrenergic input from the locus coeruleus. Even control animals showed a circadian rhythm of 5'D-II activity in some brain regions, and the effects of DMI also depended on the time of death within the 24-hr rhythm. 5D-III was not affected. Serum T4 were lower after administration of DMI, most probably because of enhanced tissue uptake of T4. This is in line with the corresponding finding in depressed patients, indicating that similar changes in both central and peripheral thyroid hormone metabolism may occur after antidepressant pharmacotherapy in both humans and rats. These data support the hypothesis that interactions with the CNS metabolism of the thyroid hormones may be involved in the mechanisms of action of DMI.",
author = "A Campos-Barros and H Meinhold and M Stula and F M{\"u}ller and R K{\"o}hler and M Eravci and O Putzien and A Baumgartner",
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Campos-Barros, A, Meinhold, H, Stula, M, Müller, F, Köhler, R, Eravci, M, Putzien, O & Baumgartner, A 1994, 'The influence of desipramine on thyroid hormone metabolism in rat brain', Journal of Pharmacology and Experimental Therapeutics, bind 268, nr. 3, s. 1143-52.

The influence of desipramine on thyroid hormone metabolism in rat brain. / Campos-Barros, A; Meinhold, H; Stula, M; Müller, F; Köhler, R; Eravci, M; Putzien, O; Baumgartner, A.

I: Journal of Pharmacology and Experimental Therapeutics, Bind 268, Nr. 3, 01.03.1994, s. 1143-52.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The influence of desipramine on thyroid hormone metabolism in rat brain

AU - Campos-Barros, A

AU - Meinhold, H

AU - Stula, M

AU - Müller, F

AU - Köhler, R

AU - Eravci, M

AU - Putzien, O

AU - Baumgartner, A

PY - 1994/3/1

Y1 - 1994/3/1

N2 - The effect of the antidepressant desipramine (DMI) on the activities of the three iodothyronine deiodinase isoenzymes involved in the central metabolism of thyroid hormones were investigated in 11 brain regions and 3 peripheral tissues in the rat. The investigations were carried out at three different times during the light/dark cycle: 5 A.M., 1 P.M. and 11 P.M. Interest is focused on changes in the two enzymes that catalyze: i) the 5'deiodination of T4 to the biologically active T3, i.e., type II 5'deiodinase (5'D-II), and ii) the 5 (or inner-ring) deiodination of T3 to the biologically inactive 3,3'T2, i.e., type III 5 deiodinase (5D-III). Fourteen days' treatment with 20 mg/kg DMI, but not with 5 mg/kg DMI, induced significant increases in 5'D-II in eight different areas of the CNS. The regions affected were identical to those that receive noradrenergic input from the locus coeruleus. Even control animals showed a circadian rhythm of 5'D-II activity in some brain regions, and the effects of DMI also depended on the time of death within the 24-hr rhythm. 5D-III was not affected. Serum T4 were lower after administration of DMI, most probably because of enhanced tissue uptake of T4. This is in line with the corresponding finding in depressed patients, indicating that similar changes in both central and peripheral thyroid hormone metabolism may occur after antidepressant pharmacotherapy in both humans and rats. These data support the hypothesis that interactions with the CNS metabolism of the thyroid hormones may be involved in the mechanisms of action of DMI.

AB - The effect of the antidepressant desipramine (DMI) on the activities of the three iodothyronine deiodinase isoenzymes involved in the central metabolism of thyroid hormones were investigated in 11 brain regions and 3 peripheral tissues in the rat. The investigations were carried out at three different times during the light/dark cycle: 5 A.M., 1 P.M. and 11 P.M. Interest is focused on changes in the two enzymes that catalyze: i) the 5'deiodination of T4 to the biologically active T3, i.e., type II 5'deiodinase (5'D-II), and ii) the 5 (or inner-ring) deiodination of T3 to the biologically inactive 3,3'T2, i.e., type III 5 deiodinase (5D-III). Fourteen days' treatment with 20 mg/kg DMI, but not with 5 mg/kg DMI, induced significant increases in 5'D-II in eight different areas of the CNS. The regions affected were identical to those that receive noradrenergic input from the locus coeruleus. Even control animals showed a circadian rhythm of 5'D-II activity in some brain regions, and the effects of DMI also depended on the time of death within the 24-hr rhythm. 5D-III was not affected. Serum T4 were lower after administration of DMI, most probably because of enhanced tissue uptake of T4. This is in line with the corresponding finding in depressed patients, indicating that similar changes in both central and peripheral thyroid hormone metabolism may occur after antidepressant pharmacotherapy in both humans and rats. These data support the hypothesis that interactions with the CNS metabolism of the thyroid hormones may be involved in the mechanisms of action of DMI.

M3 - Journal article

C2 - 8138928

VL - 268

SP - 1143

EP - 1152

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 3

ER -

Campos-Barros A, Meinhold H, Stula M, Müller F, Köhler R, Eravci M et al. The influence of desipramine on thyroid hormone metabolism in rat brain. Journal of Pharmacology and Experimental Therapeutics. 1994 mar 1;268(3):1143-52.