The hunt for origins of DNA replication in multicellular eukaryotes

J. M. Urban, M. S. Foulk, Cinzia Casella, S. A. Gerbi

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Resumé

    Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed.
    OriginalsprogEngelsk
    Artikelnummer30
    TidsskriftF1000 Prime
    Vol/bind7
    Antal sider16
    ISSN2051-9796
    DOI
    StatusUdgivet - 2015

    Emneord

    • animal genetics article budding chromatin chromatin immunoprecipitation clinical evaluation clinical feature CpG island DNA determination *DNA replication origin DNA sequence *eukaryote eukaryote evolution gene mapping genetic association genetic transcription genome analysis histone modification *multicellular eukaryote nonhuman restriction fragment yeast 5 (2 bromovinyl) 2' deoxyuridine/ec [Endogenous Compound] dihydrofolate reductase/ec [Endogenous Compound] DNA/ec [Endogenous Compound] exonuclease/ec [Endogenous Compound] guanine quadruplex/ec [Endogenous Compound] lambda exonuclease/ec [Endogenous Compound] origin recognition complex/ec [Endogenous Compound] unclassified drug

    Citer dette

    Urban, J. M., Foulk, M. S., Casella, C., & Gerbi, S. A. (2015). The hunt for origins of DNA replication in multicellular eukaryotes. F1000 Prime, 7, [30]. https://doi.org/10.12703/P7-30
    Urban, J. M. ; Foulk, M. S. ; Casella, Cinzia ; Gerbi, S. A. / The hunt for origins of DNA replication in multicellular eukaryotes. I: F1000 Prime. 2015 ; Bind 7.
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    abstract = "Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed.",
    keywords = "animal genetics article budding chromatin chromatin immunoprecipitation clinical evaluation clinical feature CpG island DNA determination *DNA replication origin DNA sequence *eukaryote eukaryote evolution gene mapping genetic association genetic transcription genome analysis histone modification *multicellular eukaryote nonhuman restriction fragment yeast 5 (2 bromovinyl) 2' deoxyuridine/ec [Endogenous Compound] dihydrofolate reductase/ec [Endogenous Compound] DNA/ec [Endogenous Compound] exonuclease/ec [Endogenous Compound] guanine quadruplex/ec [Endogenous Compound] lambda exonuclease/ec [Endogenous Compound] origin recognition complex/ec [Endogenous Compound] unclassified drug",
    author = "Urban, {J. M.} and Foulk, {M. S.} and Cinzia Casella and Gerbi, {S. A.}",
    year = "2015",
    doi = "10.12703/P7-30",
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    The hunt for origins of DNA replication in multicellular eukaryotes. / Urban, J. M.; Foulk, M. S.; Casella, Cinzia; Gerbi, S. A.

    I: F1000 Prime, Bind 7, 30, 2015.

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    TY - JOUR

    T1 - The hunt for origins of DNA replication in multicellular eukaryotes

    AU - Urban, J. M.

    AU - Foulk, M. S.

    AU - Casella, Cinzia

    AU - Gerbi, S. A.

    PY - 2015

    Y1 - 2015

    N2 - Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed.

    AB - Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed.

    KW - animal genetics article budding chromatin chromatin immunoprecipitation clinical evaluation clinical feature CpG island DNA determination DNA replication origin DNA sequence eukaryote eukaryote evolution gene mapping genetic association genetic transcript

    U2 - 10.12703/P7-30

    DO - 10.12703/P7-30

    M3 - Review

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