The heritability of blood donation: a population-based nationwide twin study

Ole Birger Pedersen, Axel Skytthe, Klaus Rostgaard, Christian Erikstrup, Gustaf Edgren, Kaspar René Nielsen, Henrik Ullum, Kirsten Ohm Kyvik, Henrik Hjalgrim

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins.

STUDY DESIGN AND METHODS: The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model.

RESULTS: A total of 274 MZ and 484 same-sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95% confidence interval [CI], 0.56-0.67) and 0.41 (95% CI, 0.36-0.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95% CI, 0.33-0.73) and 0.28 (95% CI, 0.10-0.45) of the variance in the motivation to donate blood, respectively.

CONCLUSION: Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.
OriginalsprogEngelsk
TidsskriftTransfusion
Vol/bind55
Udgave nummer9
Sider (fra-til)2169-74
ISSN0041-1132
DOI
StatusUdgivet - sep. 2015

Fingeraftryk

Dizygotic Twins
Twin Studies
Monozygotic Twins
Confidence Intervals
Population
Altruism
Volunteers
Databases

Citer dette

Pedersen, O. B., Skytthe, A., Rostgaard, K., Erikstrup, C., Edgren, G., Nielsen, K. R., ... Hjalgrim, H. (2015). The heritability of blood donation: a population-based nationwide twin study. Transfusion, 55(9), 2169-74. https://doi.org/10.1111/trf.13086
Pedersen, Ole Birger ; Skytthe, Axel ; Rostgaard, Klaus ; Erikstrup, Christian ; Edgren, Gustaf ; Nielsen, Kaspar René ; Ullum, Henrik ; Kyvik, Kirsten Ohm ; Hjalgrim, Henrik. / The heritability of blood donation : a population-based nationwide twin study. I: Transfusion. 2015 ; Bind 55, Nr. 9. s. 2169-74.
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title = "The heritability of blood donation: a population-based nationwide twin study",
abstract = "BACKGROUND: Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins.STUDY DESIGN AND METHODS: The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model.RESULTS: A total of 274 MZ and 484 same-sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95{\%} confidence interval [CI], 0.56-0.67) and 0.41 (95{\%} CI, 0.36-0.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95{\%} CI, 0.33-0.73) and 0.28 (95{\%} CI, 0.10-0.45) of the variance in the motivation to donate blood, respectively.CONCLUSION: Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.",
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Pedersen, OB, Skytthe, A, Rostgaard, K, Erikstrup, C, Edgren, G, Nielsen, KR, Ullum, H, Kyvik, KO & Hjalgrim, H 2015, 'The heritability of blood donation: a population-based nationwide twin study', Transfusion, bind 55, nr. 9, s. 2169-74. https://doi.org/10.1111/trf.13086

The heritability of blood donation : a population-based nationwide twin study. / Pedersen, Ole Birger; Skytthe, Axel; Rostgaard, Klaus; Erikstrup, Christian; Edgren, Gustaf; Nielsen, Kaspar René; Ullum, Henrik; Kyvik, Kirsten Ohm; Hjalgrim, Henrik.

I: Transfusion, Bind 55, Nr. 9, 09.2015, s. 2169-74.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The heritability of blood donation

T2 - a population-based nationwide twin study

AU - Pedersen, Ole Birger

AU - Skytthe, Axel

AU - Rostgaard, Klaus

AU - Erikstrup, Christian

AU - Edgren, Gustaf

AU - Nielsen, Kaspar René

AU - Ullum, Henrik

AU - Kyvik, Kirsten Ohm

AU - Hjalgrim, Henrik

N1 - © 2015 AABB.

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins.STUDY DESIGN AND METHODS: The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model.RESULTS: A total of 274 MZ and 484 same-sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95% confidence interval [CI], 0.56-0.67) and 0.41 (95% CI, 0.36-0.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95% CI, 0.33-0.73) and 0.28 (95% CI, 0.10-0.45) of the variance in the motivation to donate blood, respectively.CONCLUSION: Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.

AB - BACKGROUND: Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins.STUDY DESIGN AND METHODS: The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model.RESULTS: A total of 274 MZ and 484 same-sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95% confidence interval [CI], 0.56-0.67) and 0.41 (95% CI, 0.36-0.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95% CI, 0.33-0.73) and 0.28 (95% CI, 0.10-0.45) of the variance in the motivation to donate blood, respectively.CONCLUSION: Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.

U2 - 10.1111/trf.13086

DO - 10.1111/trf.13086

M3 - Journal article

C2 - 25808722

VL - 55

SP - 2169

EP - 2174

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 9

ER -

Pedersen OB, Skytthe A, Rostgaard K, Erikstrup C, Edgren G, Nielsen KR et al. The heritability of blood donation: a population-based nationwide twin study. Transfusion. 2015 sep;55(9):2169-74. https://doi.org/10.1111/trf.13086