The hepatitis C cascade of care in HIV/hepatitis C virus coinfected individuals in Europe: Regional and intra-regional differences

Olga Fursa, Amanda Mocroft, Jeffrey V Lazarus, Sarah Amele, Jens Lundgren, Raimonda Matulionyte, Line D Rasmussen, Jürgen K Rockstroh, Milosz Parczewski, David Jilich, Santiago Moreno, Anna Vassilenko, Karine Lacombe, Gilles Wandeler, Elena Borodulina, Johanna Brännström, Lothar Wiese, Chloe Orkin, Georg M N Behrens, Kamal MansinhoJose Joaquin Portu, Lars Peters, EuroSIDA Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Background: Following the introduction of direct-acting antiviral therapy in 2013, WHOlaunched the first Global Health Sector Strategy on Viral Hepatitis. We describe a hepatitis C virus (HCV) cascade of care in people with HIV (PWH) across Europe in terms of reaching the WHO elimination targets of diagnosing 90% and treating 80% of HCV-infected individuals. Methods: HIV/HCV-coinfected participants in the EuroSIDA cohort under prospective follow-up at October 1, 2019, were described using a nine-stage cascade of care. Care cascades were constructed across Europe, on a regional (n 5) and country (n 21) level. Results: Of 4773 anti-HCV positive PWH, 4446 [93.1%, 95% confidence interval (CI) 92.4-93.9)] were ever tested for HCV RNA, and 19.0% (95% CI 16.4-21.6) were currently HCV RNA positive, with the highest prevalence in Eastern and Central-Eastern Europe (33.7 and 29.6%, respectively). In Eastern Europe, 78.1% of the estimated number of chronic infections have been diagnosed, whereas this proportion was above 95% in the other four regions. Overall, 3116 persons have ever started treatment (72.5% of the ever chronically infected, 95% CI 70.9-74.0) and 2404 individuals (55.9% of the ever chronically infected, 95% CI 53.9-57.9) were cured. Cure proportion ranged from 11.2% in Belarus to 87.2% in Austria. Conclusion: In all regions except Eastern Europe, more than 90% of the study participants have been tested for HCV-RNA. In Southern and Central-Western regions, more than 80% ever chronically HCV-infected PWH received treatment. The proportion with cured HCV infection did not exceed 80% in any region, with significant heterogeneity between countries. Summary: In a pan-European cohort of PWH, all regions except Eastern Europe achieved the WHO target of diagnosing 90% of chronic HCV infections, while the target of treating 80% of eligible persons was achieved in none of the five regions.

TidsskriftAIDS (London, England)
Udgave nummer3
Sider (fra-til)423-435
StatusUdgivet - 1. mar. 2022

Bibliografisk note

Copyright © 2021 Wolters Kluwer Health, Inc.


Dyk ned i forskningsemnerne om 'The hepatitis C cascade of care in HIV/hepatitis C virus coinfected individuals in Europe: Regional and intra-regional differences'. Sammen danner de et unikt fingeraftryk.