The hairless guinea-pig as a model for treatment of acute irritation in humans

F Andersen, K Hedegaard, A Fullerton, C Bindslev-Jensen, Thomas Kongsted Petersen, Klaus Ejner Andersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2006-Aug
OriginalsprogEngelsk
TidsskriftSkin Research and Technology
Vol/bind12
Udgave nummer3
Sider (fra-til)183-9
Antal sider7
ISSN0909-752X
DOI
StatusUdgivet - 2006

Fingeraftryk

Guinea Pigs
Volunteers
Irritants
Colorimetry
1-Propanol
Skin
canola oil
carbomer

Citer dette

@article{31560b20cd4d11dbbc51000ea68e967b,
title = "The hairless guinea-pig as a model for treatment of acute irritation in humans",
abstract = "BACKGROUND: The effect of six skin care formulations on experimentally induced acute irritation was studied in hairless guinea-pigs (HLGP) and in human volunteers (HV). The formulations were a basic cream, a carbomer cream and four modifications of the carbomer cream, containing either 10{\%} isopropyl palmitate (IPP cream), 10{\%} glycerol (glycerol cream), 19.5{\%} canola oil (canola oil cream) or 0.5{\%} (-)-alpha-bisabolol (bisabolol cream). METHODS: Acute irritation was induced by occlusive tests with 1{\%} sodium lauryl sulfate aq. in both HLGP and HV, and in HV also by using nonanoic acid in n-propanol (NON) 20{\%}. The irritant reactions were treated twice daily with the formulations from the time of removal of the patches. Evaluation of skin irritation and efficacy of treatments was performed daily for 4 days using clinical scoring, evaporimetry (transepidermal water loss), hydration measurement and colorimetry. RESULTS: The glycerol cream was the only product showing effects potentially better than no treatment in HV. CONCLUSION: The HLGP was too sensitive an animal model as a predictor for effect in humans. There was no difference in efficacy of the formulations against the two different irritants in HV.",
keywords = "Animals, Disease Models, Animal, Glycerol, Guinea Pigs, Hair, Humans, Inflammation, Male, Skin, Skin Care, Skin Diseases, Skin Pigmentation",
author = "F Andersen and K Hedegaard and A Fullerton and C Bindslev-Jensen and Petersen, {Thomas Kongsted} and Andersen, {Klaus Ejner}",
year = "2006",
doi = "10.1111/j.0909-752X.2006.00148.x",
language = "English",
volume = "12",
pages = "183--9",
journal = "Skin Research and Technology",
issn = "0909-752X",
publisher = "Wiley-Blackwell",
number = "3",

}

The hairless guinea-pig as a model for treatment of acute irritation in humans. / Andersen, F; Hedegaard, K; Fullerton, A; Bindslev-Jensen, C; Petersen, Thomas Kongsted; Andersen, Klaus Ejner.

I: Skin Research and Technology, Bind 12, Nr. 3, 2006, s. 183-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The hairless guinea-pig as a model for treatment of acute irritation in humans

AU - Andersen, F

AU - Hedegaard, K

AU - Fullerton, A

AU - Bindslev-Jensen, C

AU - Petersen, Thomas Kongsted

AU - Andersen, Klaus Ejner

PY - 2006

Y1 - 2006

N2 - BACKGROUND: The effect of six skin care formulations on experimentally induced acute irritation was studied in hairless guinea-pigs (HLGP) and in human volunteers (HV). The formulations were a basic cream, a carbomer cream and four modifications of the carbomer cream, containing either 10% isopropyl palmitate (IPP cream), 10% glycerol (glycerol cream), 19.5% canola oil (canola oil cream) or 0.5% (-)-alpha-bisabolol (bisabolol cream). METHODS: Acute irritation was induced by occlusive tests with 1% sodium lauryl sulfate aq. in both HLGP and HV, and in HV also by using nonanoic acid in n-propanol (NON) 20%. The irritant reactions were treated twice daily with the formulations from the time of removal of the patches. Evaluation of skin irritation and efficacy of treatments was performed daily for 4 days using clinical scoring, evaporimetry (transepidermal water loss), hydration measurement and colorimetry. RESULTS: The glycerol cream was the only product showing effects potentially better than no treatment in HV. CONCLUSION: The HLGP was too sensitive an animal model as a predictor for effect in humans. There was no difference in efficacy of the formulations against the two different irritants in HV.

AB - BACKGROUND: The effect of six skin care formulations on experimentally induced acute irritation was studied in hairless guinea-pigs (HLGP) and in human volunteers (HV). The formulations were a basic cream, a carbomer cream and four modifications of the carbomer cream, containing either 10% isopropyl palmitate (IPP cream), 10% glycerol (glycerol cream), 19.5% canola oil (canola oil cream) or 0.5% (-)-alpha-bisabolol (bisabolol cream). METHODS: Acute irritation was induced by occlusive tests with 1% sodium lauryl sulfate aq. in both HLGP and HV, and in HV also by using nonanoic acid in n-propanol (NON) 20%. The irritant reactions were treated twice daily with the formulations from the time of removal of the patches. Evaluation of skin irritation and efficacy of treatments was performed daily for 4 days using clinical scoring, evaporimetry (transepidermal water loss), hydration measurement and colorimetry. RESULTS: The glycerol cream was the only product showing effects potentially better than no treatment in HV. CONCLUSION: The HLGP was too sensitive an animal model as a predictor for effect in humans. There was no difference in efficacy of the formulations against the two different irritants in HV.

KW - Animals

KW - Disease Models, Animal

KW - Glycerol

KW - Guinea Pigs

KW - Hair

KW - Humans

KW - Inflammation

KW - Male

KW - Skin

KW - Skin Care

KW - Skin Diseases

KW - Skin Pigmentation

U2 - 10.1111/j.0909-752X.2006.00148.x

DO - 10.1111/j.0909-752X.2006.00148.x

M3 - Journal article

C2 - 16827693

VL - 12

SP - 183

EP - 189

JO - Skin Research and Technology

JF - Skin Research and Technology

SN - 0909-752X

IS - 3

ER -