The genetic background affects the vascular response in T-type calcium channels 3.2 deficient mice

Per Svenningsen, Pernille B L Hansen

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Abstrakt

Voltage-gated calcium channels (Cav ) are important regulators of vascular tone and are attractive targets for pharmacological treatment of hypertension. The clinical used calcium blockers are often not selective for one channel but affect several types of calcium channels (Hansen 2015). L-type channels are the dominant Ca(2+) entry pathway in vascular smooth muscle cells, however, T-type calcium channels are also expressed in the cardiovascular system where they play a functional role in the regulation of both contraction and vasodilation in (Chen et al. 2003; Hansen et al. 2001). This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa Physiologica
Vol/bind217
Udgave nummer2
Sider (fra-til)101-102
ISSN1748-1708
DOI
StatusUdgivet - jun. 2016

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