Worldwide eight children have been born as a result of transplanting frozen/thawed ovarian tissue. Two of these children were born in Denmark following transport of the ovarian tissue for a period of 5 h prior to cryopreservation. One of these women, who was originally transplanted with six pieces of ovarian cortex, after having experienced a period of menopause has now conceived again following natural conception. She gave birth to a healthy girl on 23 September 2008 and is therefore the first woman in the world to have had two children, from separate pregnancies, born as a result of transplanting frozen/thawed ovarian tissue. This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment.
Ernst, E., Bergholdt, S., Jørgensen, J. S., & Andersen, C. Y. (2010). The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue. Human Reproduction, 25(5), 1280-1. https://doi.org/10.1093/humrep/deq033