The external microenvironment of healing skin wounds

Carla R Kruse, Kristo Nuutila, Cameron Cy Lee, Elizabeth Kiwanuka, Mansher Singh, Edward J Caterson, Elof Eriksson, Jens A Sørensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


The skin wound microenvironment can be divided into two main components that influence healing: the external wound microenvironment, which is outside the wound surface; and the internal wound microenvironment, underneath the surface, to which the cells within the wound are exposed. Treatment methods that directly alter the features of the external wound microenvironment indirectly affect the internal wound microenvironment due to the exchange between the two compartments. In this review, we focus on the effects of temperature, pressure (positive and negative), hydration, gases (oxygen and carbon dioxide), pH, and anti-microbial treatment on the wound. These factors are well described in the literature and can be modified with treatment methods available in the clinic. Understanding the roles of these factors in wound pathophysiology is of central importance in wound treatment.

TidsskriftWound Repair and Regeneration
Udgave nummer4
Sider (fra-til)456-464
StatusUdgivet - 11. apr. 2015

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