The Etiology of Primary Hyperhidrosis: A Systematic Review

Moshe Hashmonai*, Alan E.P. Cameron, Cliff P. Connery, Noel Perin, Peter B. Licht

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. Methods: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed. Additional publications were obtained from the references of these articles. Results: Some anatomical and pathophysiological characteristics (as well as enzymatic, metabolic, and neurological dysfunctions) have been observed in hyperhidrotic subjects; three main possible etiological factors predominate. A familial trait seems to exist, and genetic loci associated with hyperhidrosis have been identified. Histological differences were observed in sympathetic ganglia of hyperhidrotic subjects: the ganglia were larger and contained a higher number of ganglion cells. A higher expression of acetylcholine and alpha-7 neuronal nicotinic receptor subunit in the sympathetic ganglia of patients with hyperhidrosis has been reported. Conclusions: Despite these accumulated data, the etiology of primary hyperhidrosis remains obscure. Nevertheless, three main lines for future research seem to be delineated: genetics, histological observations, and enzymatic studies.

OriginalsprogEngelsk
TidsskriftClinical Autonomic Research
Vol/bind27
Udgave nummer6
Sider (fra-til)379–383
ISSN0959-9851
DOI
StatusUdgivet - 2017

Fingeraftryk

Ganglia
PubMed
Acetylcholine
Databases
Population

Citer dette

Hashmonai, Moshe ; Cameron, Alan E.P. ; Connery, Cliff P. ; Perin, Noel ; Licht, Peter B. / The Etiology of Primary Hyperhidrosis : A Systematic Review. I: Clinical Autonomic Research. 2017 ; Bind 27, Nr. 6. s. 379–383.
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abstract = "Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5{\%} of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. Methods: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed. Additional publications were obtained from the references of these articles. Results: Some anatomical and pathophysiological characteristics (as well as enzymatic, metabolic, and neurological dysfunctions) have been observed in hyperhidrotic subjects; three main possible etiological factors predominate. A familial trait seems to exist, and genetic loci associated with hyperhidrosis have been identified. Histological differences were observed in sympathetic ganglia of hyperhidrotic subjects: the ganglia were larger and contained a higher number of ganglion cells. A higher expression of acetylcholine and alpha-7 neuronal nicotinic receptor subunit in the sympathetic ganglia of patients with hyperhidrosis has been reported. Conclusions: Despite these accumulated data, the etiology of primary hyperhidrosis remains obscure. Nevertheless, three main lines for future research seem to be delineated: genetics, histological observations, and enzymatic studies.",
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author = "Moshe Hashmonai and Cameron, {Alan E.P.} and Connery, {Cliff P.} and Noel Perin and Licht, {Peter B.}",
year = "2017",
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Hashmonai, M, Cameron, AEP, Connery, CP, Perin, N & Licht, PB 2017, 'The Etiology of Primary Hyperhidrosis: A Systematic Review', Clinical Autonomic Research, bind 27, nr. 6, s. 379–383. https://doi.org/10.1007/s10286-017-0456-0

The Etiology of Primary Hyperhidrosis : A Systematic Review. / Hashmonai, Moshe; Cameron, Alan E.P.; Connery, Cliff P.; Perin, Noel; Licht, Peter B.

I: Clinical Autonomic Research, Bind 27, Nr. 6, 2017, s. 379–383.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - The Etiology of Primary Hyperhidrosis

T2 - A Systematic Review

AU - Hashmonai, Moshe

AU - Cameron, Alan E.P.

AU - Connery, Cliff P.

AU - Perin, Noel

AU - Licht, Peter B.

PY - 2017

Y1 - 2017

N2 - Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. Methods: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed. Additional publications were obtained from the references of these articles. Results: Some anatomical and pathophysiological characteristics (as well as enzymatic, metabolic, and neurological dysfunctions) have been observed in hyperhidrotic subjects; three main possible etiological factors predominate. A familial trait seems to exist, and genetic loci associated with hyperhidrosis have been identified. Histological differences were observed in sympathetic ganglia of hyperhidrotic subjects: the ganglia were larger and contained a higher number of ganglion cells. A higher expression of acetylcholine and alpha-7 neuronal nicotinic receptor subunit in the sympathetic ganglia of patients with hyperhidrosis has been reported. Conclusions: Despite these accumulated data, the etiology of primary hyperhidrosis remains obscure. Nevertheless, three main lines for future research seem to be delineated: genetics, histological observations, and enzymatic studies.

AB - Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. Methods: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed. Additional publications were obtained from the references of these articles. Results: Some anatomical and pathophysiological characteristics (as well as enzymatic, metabolic, and neurological dysfunctions) have been observed in hyperhidrotic subjects; three main possible etiological factors predominate. A familial trait seems to exist, and genetic loci associated with hyperhidrosis have been identified. Histological differences were observed in sympathetic ganglia of hyperhidrotic subjects: the ganglia were larger and contained a higher number of ganglion cells. A higher expression of acetylcholine and alpha-7 neuronal nicotinic receptor subunit in the sympathetic ganglia of patients with hyperhidrosis has been reported. Conclusions: Despite these accumulated data, the etiology of primary hyperhidrosis remains obscure. Nevertheless, three main lines for future research seem to be delineated: genetics, histological observations, and enzymatic studies.

KW - Epidemiology

KW - Etiology

KW - Primary Hyperhidrosis

KW - Sympathetic System

U2 - 10.1007/s10286-017-0456-0

DO - 10.1007/s10286-017-0456-0

M3 - Review

C2 - 28823102

AN - SCOPUS:85027886867

VL - 27

SP - 379

EP - 383

JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

SN - 0959-9851

IS - 6

ER -