The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

J Danesh, S Erqou, M Walker, S G Thompson, R Tipping, C Ford, S Pressel, G Walldius, I Jungner, A R Folsom, L E Chambless, M Knuiman, P H Whincup, S G Wannamethee, R W Morris, J Willeit, S Kiechl, P Santer, A Mayr, N Wald & 182 andre S Ebrahim, D A Lawlor, J W G Yarnell, J Gallacher, E Casiglia, V Tikhonoff, P J Nietert, S E Sutherland, D L Bachman, J E Keil, M Cushman, B M Psaty, R P Tracy, A Tybjaerg-Hansen, B G Nordestgaard, R Frikke-Schmidt, S Giampaoli, L Palmieri, S Panico, D Vanuzzo, L Pilotto, L Simons, J McCallum, Y Friedlander, F G R Fowkes, A J Lee, F B Smith, J Taylor, J Guralnik, C Phillips, R Wallace, D Blazer, K T Khaw, J H Jansson, C Donfrancesco, V Salomaa, K Harald, P Jousilahti, E Vartiainen, M Woodward, R B D'Agostino, P A Wolf, R S Vasan, M J Pencina, E-M Bladbjerg, T Jorgensen, L Moller, J Jespersen, R Dankner, A Chetrit, F Lubin, A Rosengren, L Wilhelmsen, G Lappas, H Eriksson, C Bjorkelund, P Cremer, D Nagel, R Tilvis, T Strandberg, B Rodriguez, L M Bouter, R J Heine, J M Dekker, G Nijpels, C D A Stehouwer, E Rimm, J Pai, S Sato, H Iso, A Kitamura, H Noda, U Goldbourt, V Salomaa, J T Salonen, K Nyyssönen, T-P Tuomainen, D Deeg, J L Poppelaars, T Meade, J Cooper, B Hedblad, G Berglund, G Engstrom, A Döring, W Koenig, C Meisinger, W Mraz, L Kuller, R Selmer, A Tverdal, W Nystad, R Gillum, M Mussolino, S Hankinson, J Manson, B De Stavola, C Knottenbelt, J A Cooper, K A Bauer, R D Rosenberg, S Sato, Y Naito, I Holme, H Nakagawa, H Miura, P Ducimetiere, X Jouven, C Crespo, M Garcia-Palmieri, P Amouyel, D Arveiler, A Evans, J Ferrieres, H Schulte, G Assmann, J Shepherd, C Packard, N Sattar, B Cantin, B Lamarche, J-P Després, G R Dagenais, E Barrett-Connor, D Wingard, R Bettencourt, V Gudnason, T Aspelund, G Sigurdsson, B Thorsson, M Trevisan, J Witteman, I Kardys, M Breteler, A Hofman, H Tunstall-Pedoe, R Tavendale, G D O Lowe, Y Ben-Shlomo, B V Howard, Y Zhang, L Best, J Umans, A Onat, T W Meade, I Njolstad, E Mathiesen, M L Lochen, T Wilsgaard, J M Gaziano, M Stampfer, P Ridker, H Ulmer, G Diem, H Concin, F Rodeghiero, A Tosetto, E Brunner, M Shipley, J Buring, S M Cobbe, I Ford, M Robertson, Y He, A M Ibanez, E J M Feskens, D Kromhout, R Collins, E Di Angelantonio, S Kaptoge, S Lewington, L Orfei, L Pennells, P Perry, K Ray, N Sarwar, M Scherman, A Thompson, S Watson, F Wensley, I R White, A M Wood

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind22
Udgave nummer12
Sider (fra-til)839-869
Antal sider30
ISSN0393-2990
DOI
StatusUdgivet - 2007

Fingeraftryk

Statistical Factor Analysis
Prospective Studies
Lipids
Databases
Population

Citer dette

Danesh, J ; Erqou, S ; Walker, M ; Thompson, S G ; Tipping, R ; Ford, C ; Pressel, S ; Walldius, G ; Jungner, I ; Folsom, A R ; Chambless, L E ; Knuiman, M ; Whincup, P H ; Wannamethee, S G ; Morris, R W ; Willeit, J ; Kiechl, S ; Santer, P ; Mayr, A ; Wald, N ; Ebrahim, S ; Lawlor, D A ; Yarnell, J W G ; Gallacher, J ; Casiglia, E ; Tikhonoff, V ; Nietert, P J ; Sutherland, S E ; Bachman, D L ; Keil, J E ; Cushman, M ; Psaty, B M ; Tracy, R P ; Tybjaerg-Hansen, A ; Nordestgaard, B G ; Frikke-Schmidt, R ; Giampaoli, S ; Palmieri, L ; Panico, S ; Vanuzzo, D ; Pilotto, L ; Simons, L ; McCallum, J ; Friedlander, Y ; Fowkes, F G R ; Lee, A J ; Smith, F B ; Taylor, J ; Guralnik, J ; Phillips, C ; Wallace, R ; Blazer, D ; Khaw, K T ; Jansson, J H ; Donfrancesco, C ; Salomaa, V ; Harald, K ; Jousilahti, P ; Vartiainen, E ; Woodward, M ; D'Agostino, R B ; Wolf, P A ; Vasan, R S ; Pencina, M J ; Bladbjerg, E-M ; Jorgensen, T ; Moller, L ; Jespersen, J ; Dankner, R ; Chetrit, A ; Lubin, F ; Rosengren, A ; Wilhelmsen, L ; Lappas, G ; Eriksson, H ; Bjorkelund, C ; Cremer, P ; Nagel, D ; Tilvis, R ; Strandberg, T ; Rodriguez, B ; Bouter, L M ; Heine, R J ; Dekker, J M ; Nijpels, G ; Stehouwer, C D A ; Rimm, E ; Pai, J ; Sato, S ; Iso, H ; Kitamura, A ; Noda, H ; Goldbourt, U ; Salomaa, V ; Salonen, J T ; Nyyssönen, K ; Tuomainen, T-P ; Deeg, D ; Poppelaars, J L ; Meade, T ; Cooper, J ; Hedblad, B ; Berglund, G ; Engstrom, G ; Döring, A ; Koenig, W ; Meisinger, C ; Mraz, W ; Kuller, L ; Selmer, R ; Tverdal, A ; Nystad, W ; Gillum, R ; Mussolino, M ; Hankinson, S ; Manson, J ; De Stavola, B ; Knottenbelt, C ; Cooper, J A ; Bauer, K A ; Rosenberg, R D ; Sato, S ; Naito, Y ; Holme, I ; Nakagawa, H ; Miura, H ; Ducimetiere, P ; Jouven, X ; Crespo, C ; Garcia-Palmieri, M ; Amouyel, P ; Arveiler, D ; Evans, A ; Ferrieres, J ; Schulte, H ; Assmann, G ; Shepherd, J ; Packard, C ; Sattar, N ; Cantin, B ; Lamarche, B ; Després, J-P ; Dagenais, G R ; Barrett-Connor, E ; Wingard, D ; Bettencourt, R ; Gudnason, V ; Aspelund, T ; Sigurdsson, G ; Thorsson, B ; Trevisan, M ; Witteman, J ; Kardys, I ; Breteler, M ; Hofman, A ; Tunstall-Pedoe, H ; Tavendale, R ; Lowe, G D O ; Ben-Shlomo, Y ; Howard, B V ; Zhang, Y ; Best, L ; Umans, J ; Onat, A ; Meade, T W ; Njolstad, I ; Mathiesen, E ; Lochen, M L ; Wilsgaard, T ; Gaziano, J M ; Stampfer, M ; Ridker, P ; Ulmer, H ; Diem, G ; Concin, H ; Rodeghiero, F ; Tosetto, A ; Brunner, E ; Shipley, M ; Buring, J ; Cobbe, S M ; Ford, I ; Robertson, M ; He, Y ; Ibanez, A M ; Feskens, E J M ; Kromhout, D ; Collins, R ; Di Angelantonio, E ; Kaptoge, S ; Lewington, S ; Orfei, L ; Pennells, L ; Perry, P ; Ray, K ; Sarwar, N ; Scherman, M ; Thompson, A ; Watson, S ; Wensley, F ; White, I R ; Wood, A M. / The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. I: European Journal of Epidemiology. 2007 ; Bind 22, Nr. 12. s. 839-869.
@article{171fece0fa7811dc86ef000ea68e967b,
title = "The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases",
abstract = "Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid and inflammatory markers, other characteristics, as well as major cardiovascular morbidity and cause-specific mortality. Information on repeat measurements on relevant characteristics has been collected in approximately 340,000 participants to enable estimation of and correction for within-person variability. Re-analysis of individual data will yield up to approximately 69,000 incident fatal or nonfatal first ever major cardiovascular outcomes recorded during about 11.7 million person years at risk. The primary analyses will involve age-specific regression models in people without known baseline cardiovascular disease in relation to fatal or nonfatal first ever coronary heart disease outcomes. This initiative will characterize more precisely and in greater detail than has previously been possible the shape and strength of the age- and sex-specific associations of several lipid and inflammatory markers with incident coronary heart disease outcomes (and, secondarily, with other incident cardiovascular outcomes) under a wide range of circumstances. It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value.",
author = "J Danesh and S Erqou and M Walker and Thompson, {S G} and R Tipping and C Ford and S Pressel and G Walldius and I Jungner and Folsom, {A R} and Chambless, {L E} and M Knuiman and Whincup, {P H} and Wannamethee, {S G} and Morris, {R W} and J Willeit and S Kiechl and P Santer and A Mayr and N Wald and S Ebrahim and Lawlor, {D A} and Yarnell, {J W G} and J Gallacher and E Casiglia and V Tikhonoff and Nietert, {P J} and Sutherland, {S E} and Bachman, {D L} and Keil, {J E} and M Cushman and Psaty, {B M} and Tracy, {R P} and A Tybjaerg-Hansen and Nordestgaard, {B G} and R Frikke-Schmidt and S Giampaoli and L Palmieri and S Panico and D Vanuzzo and L Pilotto and L Simons and J McCallum and Y Friedlander and Fowkes, {F G R} and Lee, {A J} and Smith, {F B} and J Taylor and J Guralnik and C Phillips and R Wallace and D Blazer and Khaw, {K T} and Jansson, {J H} and C Donfrancesco and V Salomaa and K Harald and P Jousilahti and E Vartiainen and M Woodward and D'Agostino, {R B} and Wolf, {P A} and Vasan, {R S} and Pencina, {M J} and E-M Bladbjerg and T Jorgensen and L Moller and J Jespersen and R Dankner and A Chetrit and F Lubin and A Rosengren and L Wilhelmsen and G Lappas and H Eriksson and C Bjorkelund and P Cremer and D Nagel and R Tilvis and T Strandberg and B Rodriguez and Bouter, {L M} and Heine, {R J} and Dekker, {J M} and G Nijpels and Stehouwer, {C D A} and E Rimm and J Pai and S Sato and H Iso and A Kitamura and H Noda and U Goldbourt and V Salomaa and Salonen, {J T} and K Nyyss{\"o}nen and T-P Tuomainen and D Deeg and Poppelaars, {J L} and T Meade and J Cooper and B Hedblad and G Berglund and G Engstrom and A D{\"o}ring and W Koenig and C Meisinger and W Mraz and L Kuller and R Selmer and A Tverdal and W Nystad and R Gillum and M Mussolino and S Hankinson and J Manson and {De Stavola}, B and C Knottenbelt and Cooper, {J A} and Bauer, {K A} and Rosenberg, {R D} and S Sato and Y Naito and I Holme and H Nakagawa and H Miura and P Ducimetiere and X Jouven and C Crespo and M Garcia-Palmieri and P Amouyel and D Arveiler and A Evans and J Ferrieres and H Schulte and G Assmann and J Shepherd and C Packard and N Sattar and B Cantin and B Lamarche and J-P Despr{\'e}s and Dagenais, {G R} and E Barrett-Connor and D Wingard and R Bettencourt and V Gudnason and T Aspelund and G Sigurdsson and B Thorsson and M Trevisan and J Witteman and I Kardys and M Breteler and A Hofman and H Tunstall-Pedoe and R Tavendale and Lowe, {G D O} and Y Ben-Shlomo and Howard, {B V} and Y Zhang and L Best and J Umans and A Onat and Meade, {T W} and I Njolstad and E Mathiesen and Lochen, {M L} and T Wilsgaard and Gaziano, {J M} and M Stampfer and P Ridker and H Ulmer and G Diem and H Concin and F Rodeghiero and A Tosetto and E Brunner and M Shipley and J Buring and Cobbe, {S M} and I Ford and M Robertson and Y He and Ibanez, {A M} and Feskens, {E J M} and D Kromhout and R Collins and {Di Angelantonio}, E and S Kaptoge and S Lewington and L Orfei and L Pennells and P Perry and K Ray and N Sarwar and M Scherman and A Thompson and S Watson and F Wensley and White, {I R} and Wood, {A M}",
year = "2007",
doi = "10.1007/s10654-007-9165-7",
language = "English",
volume = "22",
pages = "839--869",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer",
number = "12",

}

Danesh, J, Erqou, S, Walker, M, Thompson, SG, Tipping, R, Ford, C, Pressel, S, Walldius, G, Jungner, I, Folsom, AR, Chambless, LE, Knuiman, M, Whincup, PH, Wannamethee, SG, Morris, RW, Willeit, J, Kiechl, S, Santer, P, Mayr, A, Wald, N, Ebrahim, S, Lawlor, DA, Yarnell, JWG, Gallacher, J, Casiglia, E, Tikhonoff, V, Nietert, PJ, Sutherland, SE, Bachman, DL, Keil, JE, Cushman, M, Psaty, BM, Tracy, RP, Tybjaerg-Hansen, A, Nordestgaard, BG, Frikke-Schmidt, R, Giampaoli, S, Palmieri, L, Panico, S, Vanuzzo, D, Pilotto, L, Simons, L, McCallum, J, Friedlander, Y, Fowkes, FGR, Lee, AJ, Smith, FB, Taylor, J, Guralnik, J, Phillips, C, Wallace, R, Blazer, D, Khaw, KT, Jansson, JH, Donfrancesco, C, Salomaa, V, Harald, K, Jousilahti, P, Vartiainen, E, Woodward, M, D'Agostino, RB, Wolf, PA, Vasan, RS, Pencina, MJ, Bladbjerg, E-M, Jorgensen, T, Moller, L, Jespersen, J, Dankner, R, Chetrit, A, Lubin, F, Rosengren, A, Wilhelmsen, L, Lappas, G, Eriksson, H, Bjorkelund, C, Cremer, P, Nagel, D, Tilvis, R, Strandberg, T, Rodriguez, B, Bouter, LM, Heine, RJ, Dekker, JM, Nijpels, G, Stehouwer, CDA, Rimm, E, Pai, J, Sato, S, Iso, H, Kitamura, A, Noda, H, Goldbourt, U, Salomaa, V, Salonen, JT, Nyyssönen, K, Tuomainen, T-P, Deeg, D, Poppelaars, JL, Meade, T, Cooper, J, Hedblad, B, Berglund, G, Engstrom, G, Döring, A, Koenig, W, Meisinger, C, Mraz, W, Kuller, L, Selmer, R, Tverdal, A, Nystad, W, Gillum, R, Mussolino, M, Hankinson, S, Manson, J, De Stavola, B, Knottenbelt, C, Cooper, JA, Bauer, KA, Rosenberg, RD, Sato, S, Naito, Y, Holme, I, Nakagawa, H, Miura, H, Ducimetiere, P, Jouven, X, Crespo, C, Garcia-Palmieri, M, Amouyel, P, Arveiler, D, Evans, A, Ferrieres, J, Schulte, H, Assmann, G, Shepherd, J, Packard, C, Sattar, N, Cantin, B, Lamarche, B, Després, J-P, Dagenais, GR, Barrett-Connor, E, Wingard, D, Bettencourt, R, Gudnason, V, Aspelund, T, Sigurdsson, G, Thorsson, B, Trevisan, M, Witteman, J, Kardys, I, Breteler, M, Hofman, A, Tunstall-Pedoe, H, Tavendale, R, Lowe, GDO, Ben-Shlomo, Y, Howard, BV, Zhang, Y, Best, L, Umans, J, Onat, A, Meade, TW, Njolstad, I, Mathiesen, E, Lochen, ML, Wilsgaard, T, Gaziano, JM, Stampfer, M, Ridker, P, Ulmer, H, Diem, G, Concin, H, Rodeghiero, F, Tosetto, A, Brunner, E, Shipley, M, Buring, J, Cobbe, SM, Ford, I, Robertson, M, He, Y, Ibanez, AM, Feskens, EJM, Kromhout, D, Collins, R, Di Angelantonio, E, Kaptoge, S, Lewington, S, Orfei, L, Pennells, L, Perry, P, Ray, K, Sarwar, N, Scherman, M, Thompson, A, Watson, S, Wensley, F, White, IR & Wood, AM 2007, 'The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases', European Journal of Epidemiology, bind 22, nr. 12, s. 839-869. https://doi.org/10.1007/s10654-007-9165-7

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. / Danesh, J; Erqou, S; Walker, M; Thompson, S G; Tipping, R; Ford, C; Pressel, S; Walldius, G; Jungner, I; Folsom, A R; Chambless, L E; Knuiman, M; Whincup, P H; Wannamethee, S G; Morris, R W; Willeit, J; Kiechl, S; Santer, P; Mayr, A; Wald, N; Ebrahim, S; Lawlor, D A; Yarnell, J W G; Gallacher, J; Casiglia, E; Tikhonoff, V; Nietert, P J; Sutherland, S E; Bachman, D L; Keil, J E; Cushman, M; Psaty, B M; Tracy, R P; Tybjaerg-Hansen, A; Nordestgaard, B G; Frikke-Schmidt, R; Giampaoli, S; Palmieri, L; Panico, S; Vanuzzo, D; Pilotto, L; Simons, L; McCallum, J; Friedlander, Y; Fowkes, F G R; Lee, A J; Smith, F B; Taylor, J; Guralnik, J; Phillips, C; Wallace, R; Blazer, D; Khaw, K T; Jansson, J H; Donfrancesco, C; Salomaa, V; Harald, K; Jousilahti, P; Vartiainen, E; Woodward, M; D'Agostino, R B; Wolf, P A; Vasan, R S; Pencina, M J; Bladbjerg, E-M; Jorgensen, T; Moller, L; Jespersen, J; Dankner, R; Chetrit, A; Lubin, F; Rosengren, A; Wilhelmsen, L; Lappas, G; Eriksson, H; Bjorkelund, C; Cremer, P; Nagel, D; Tilvis, R; Strandberg, T; Rodriguez, B; Bouter, L M; Heine, R J; Dekker, J M; Nijpels, G; Stehouwer, C D A; Rimm, E; Pai, J; Sato, S; Iso, H; Kitamura, A; Noda, H; Goldbourt, U; Salomaa, V; Salonen, J T; Nyyssönen, K; Tuomainen, T-P; Deeg, D; Poppelaars, J L; Meade, T; Cooper, J; Hedblad, B; Berglund, G; Engstrom, G; Döring, A; Koenig, W; Meisinger, C; Mraz, W; Kuller, L; Selmer, R; Tverdal, A; Nystad, W; Gillum, R; Mussolino, M; Hankinson, S; Manson, J; De Stavola, B; Knottenbelt, C; Cooper, J A; Bauer, K A; Rosenberg, R D; Sato, S; Naito, Y; Holme, I; Nakagawa, H; Miura, H; Ducimetiere, P; Jouven, X; Crespo, C; Garcia-Palmieri, M; Amouyel, P; Arveiler, D; Evans, A; Ferrieres, J; Schulte, H; Assmann, G; Shepherd, J; Packard, C; Sattar, N; Cantin, B; Lamarche, B; Després, J-P; Dagenais, G R; Barrett-Connor, E; Wingard, D; Bettencourt, R; Gudnason, V; Aspelund, T; Sigurdsson, G; Thorsson, B; Trevisan, M; Witteman, J; Kardys, I; Breteler, M; Hofman, A; Tunstall-Pedoe, H; Tavendale, R; Lowe, G D O; Ben-Shlomo, Y; Howard, B V; Zhang, Y; Best, L; Umans, J; Onat, A; Meade, T W; Njolstad, I; Mathiesen, E; Lochen, M L; Wilsgaard, T; Gaziano, J M; Stampfer, M; Ridker, P; Ulmer, H; Diem, G; Concin, H; Rodeghiero, F; Tosetto, A; Brunner, E; Shipley, M; Buring, J; Cobbe, S M; Ford, I; Robertson, M; He, Y; Ibanez, A M; Feskens, E J M; Kromhout, D; Collins, R; Di Angelantonio, E; Kaptoge, S; Lewington, S; Orfei, L; Pennells, L; Perry, P; Ray, K; Sarwar, N; Scherman, M; Thompson, A; Watson, S; Wensley, F; White, I R; Wood, A M.

I: European Journal of Epidemiology, Bind 22, Nr. 12, 2007, s. 839-869.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

AU - Danesh, J

AU - Erqou, S

AU - Walker, M

AU - Thompson, S G

AU - Tipping, R

AU - Ford, C

AU - Pressel, S

AU - Walldius, G

AU - Jungner, I

AU - Folsom, A R

AU - Chambless, L E

AU - Knuiman, M

AU - Whincup, P H

AU - Wannamethee, S G

AU - Morris, R W

AU - Willeit, J

AU - Kiechl, S

AU - Santer, P

AU - Mayr, A

AU - Wald, N

AU - Ebrahim, S

AU - Lawlor, D A

AU - Yarnell, J W G

AU - Gallacher, J

AU - Casiglia, E

AU - Tikhonoff, V

AU - Nietert, P J

AU - Sutherland, S E

AU - Bachman, D L

AU - Keil, J E

AU - Cushman, M

AU - Psaty, B M

AU - Tracy, R P

AU - Tybjaerg-Hansen, A

AU - Nordestgaard, B G

AU - Frikke-Schmidt, R

AU - Giampaoli, S

AU - Palmieri, L

AU - Panico, S

AU - Vanuzzo, D

AU - Pilotto, L

AU - Simons, L

AU - McCallum, J

AU - Friedlander, Y

AU - Fowkes, F G R

AU - Lee, A J

AU - Smith, F B

AU - Taylor, J

AU - Guralnik, J

AU - Phillips, C

AU - Wallace, R

AU - Blazer, D

AU - Khaw, K T

AU - Jansson, J H

AU - Donfrancesco, C

AU - Salomaa, V

AU - Harald, K

AU - Jousilahti, P

AU - Vartiainen, E

AU - Woodward, M

AU - D'Agostino, R B

AU - Wolf, P A

AU - Vasan, R S

AU - Pencina, M J

AU - Bladbjerg, E-M

AU - Jorgensen, T

AU - Moller, L

AU - Jespersen, J

AU - Dankner, R

AU - Chetrit, A

AU - Lubin, F

AU - Rosengren, A

AU - Wilhelmsen, L

AU - Lappas, G

AU - Eriksson, H

AU - Bjorkelund, C

AU - Cremer, P

AU - Nagel, D

AU - Tilvis, R

AU - Strandberg, T

AU - Rodriguez, B

AU - Bouter, L M

AU - Heine, R J

AU - Dekker, J M

AU - Nijpels, G

AU - Stehouwer, C D A

AU - Rimm, E

AU - Pai, J

AU - Sato, S

AU - Iso, H

AU - Kitamura, A

AU - Noda, H

AU - Goldbourt, U

AU - Salomaa, V

AU - Salonen, J T

AU - Nyyssönen, K

AU - Tuomainen, T-P

AU - Deeg, D

AU - Poppelaars, J L

AU - Meade, T

AU - Cooper, J

AU - Hedblad, B

AU - Berglund, G

AU - Engstrom, G

AU - Döring, A

AU - Koenig, W

AU - Meisinger, C

AU - Mraz, W

AU - Kuller, L

AU - Selmer, R

AU - Tverdal, A

AU - Nystad, W

AU - Gillum, R

AU - Mussolino, M

AU - Hankinson, S

AU - Manson, J

AU - De Stavola, B

AU - Knottenbelt, C

AU - Cooper, J A

AU - Bauer, K A

AU - Rosenberg, R D

AU - Sato, S

AU - Naito, Y

AU - Holme, I

AU - Nakagawa, H

AU - Miura, H

AU - Ducimetiere, P

AU - Jouven, X

AU - Crespo, C

AU - Garcia-Palmieri, M

AU - Amouyel, P

AU - Arveiler, D

AU - Evans, A

AU - Ferrieres, J

AU - Schulte, H

AU - Assmann, G

AU - Shepherd, J

AU - Packard, C

AU - Sattar, N

AU - Cantin, B

AU - Lamarche, B

AU - Després, J-P

AU - Dagenais, G R

AU - Barrett-Connor, E

AU - Wingard, D

AU - Bettencourt, R

AU - Gudnason, V

AU - Aspelund, T

AU - Sigurdsson, G

AU - Thorsson, B

AU - Trevisan, M

AU - Witteman, J

AU - Kardys, I

AU - Breteler, M

AU - Hofman, A

AU - Tunstall-Pedoe, H

AU - Tavendale, R

AU - Lowe, G D O

AU - Ben-Shlomo, Y

AU - Howard, B V

AU - Zhang, Y

AU - Best, L

AU - Umans, J

AU - Onat, A

AU - Meade, T W

AU - Njolstad, I

AU - Mathiesen, E

AU - Lochen, M L

AU - Wilsgaard, T

AU - Gaziano, J M

AU - Stampfer, M

AU - Ridker, P

AU - Ulmer, H

AU - Diem, G

AU - Concin, H

AU - Rodeghiero, F

AU - Tosetto, A

AU - Brunner, E

AU - Shipley, M

AU - Buring, J

AU - Cobbe, S M

AU - Ford, I

AU - Robertson, M

AU - He, Y

AU - Ibanez, A M

AU - Feskens, E J M

AU - Kromhout, D

AU - Collins, R

AU - Di Angelantonio, E

AU - Kaptoge, S

AU - Lewington, S

AU - Orfei, L

AU - Pennells, L

AU - Perry, P

AU - Ray, K

AU - Sarwar, N

AU - Scherman, M

AU - Thompson, A

AU - Watson, S

AU - Wensley, F

AU - White, I R

AU - Wood, A M

PY - 2007

Y1 - 2007

N2 - Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid and inflammatory markers, other characteristics, as well as major cardiovascular morbidity and cause-specific mortality. Information on repeat measurements on relevant characteristics has been collected in approximately 340,000 participants to enable estimation of and correction for within-person variability. Re-analysis of individual data will yield up to approximately 69,000 incident fatal or nonfatal first ever major cardiovascular outcomes recorded during about 11.7 million person years at risk. The primary analyses will involve age-specific regression models in people without known baseline cardiovascular disease in relation to fatal or nonfatal first ever coronary heart disease outcomes. This initiative will characterize more precisely and in greater detail than has previously been possible the shape and strength of the age- and sex-specific associations of several lipid and inflammatory markers with incident coronary heart disease outcomes (and, secondarily, with other incident cardiovascular outcomes) under a wide range of circumstances. It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value.

AB - Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid and inflammatory markers, other characteristics, as well as major cardiovascular morbidity and cause-specific mortality. Information on repeat measurements on relevant characteristics has been collected in approximately 340,000 participants to enable estimation of and correction for within-person variability. Re-analysis of individual data will yield up to approximately 69,000 incident fatal or nonfatal first ever major cardiovascular outcomes recorded during about 11.7 million person years at risk. The primary analyses will involve age-specific regression models in people without known baseline cardiovascular disease in relation to fatal or nonfatal first ever coronary heart disease outcomes. This initiative will characterize more precisely and in greater detail than has previously been possible the shape and strength of the age- and sex-specific associations of several lipid and inflammatory markers with incident coronary heart disease outcomes (and, secondarily, with other incident cardiovascular outcomes) under a wide range of circumstances. It will, therefore, help to determine to what extent such associations are independent from possible confounding factors and to what extent such markers (separately and in combination) provide incremental predictive value.

U2 - 10.1007/s10654-007-9165-7

DO - 10.1007/s10654-007-9165-7

M3 - Journal article

VL - 22

SP - 839

EP - 869

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 12

ER -