The Efficacy and Safety of Concurrent Collagenase Clostridium Histolyticum Injections for 2 Dupuytren Contractures in the Same Hand: A Prospective, Multicenter Study

R. G. Gaston, Søren Larsen, G. M. Pess, S. Coleman, B. Dean, B. M. Cohen, G. J. Kaufman, J. P. Tursi, L. C. Hurst

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Purpose To evaluate efficacy and safety of concurrent administration of 2 collagenase clostridium histolyticum (CCH) injections to treat 2 joints in the same hand with Dupuytren fixed flexion contractures (FFCs). Methods Patients with 2 or more contractures in the same hand caused by palpable cords participated in a 60-day, multicenter, open-label, phase 3b study. Two 0.58 mg CCH doses were injected into 1 or 2 cords in the same hand (1 injection per affected joint) during the same visit. Finger extension was performed approximately 24, 48, or 72 or more hours later. Changes in FFC and range of motion, incidence of clinical success (FFC
TidsskriftJournal of Hand Surgery (American Volume)
Udgave nummer10
Sider (fra-til)1963-1971
StatusUdgivet - 2015

Bibliografisk note

Auxilium Pharmaceuticals, Inc. 0 26216077


  • Collagenase clostridium histolyticum concurrent injections Dupuytren disease fixed flexion contracture range of motion DISEASE