The Efficacy and Safety of Concurrent Collagenase Clostridium Histolyticum Injections for 2 Dupuytren Contractures in the Same Hand: A Prospective, Multicenter Study

R. G. Gaston, Søren Larsen, G. M. Pess, S. Coleman, B. Dean, B. M. Cohen, G. J. Kaufman, J. P. Tursi, L. C. Hurst

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Purpose To evaluate efficacy and safety of concurrent administration of 2 collagenase clostridium histolyticum (CCH) injections to treat 2 joints in the same hand with Dupuytren fixed flexion contractures (FFCs). Methods Patients with 2 or more contractures in the same hand caused by palpable cords participated in a 60-day, multicenter, open-label, phase 3b study. Two 0.58 mg CCH doses were injected into 1 or 2 cords in the same hand (1 injection per affected joint) during the same visit. Finger extension was performed approximately 24, 48, or 72 or more hours later. Changes in FFC and range of motion, incidence of clinical success (FFC
OriginalsprogEngelsk
TidsskriftJournal of Hand Surgery (American Volume)
Vol/bind40
Udgave nummer10
Sider (fra-til)1963-1971
ISSN0363-5023
DOI
StatusUdgivet - 2015

Bibliografisk note

Auxilium Pharmaceuticals, Inc. 0 26216077

Emneord

  • Collagenase clostridium histolyticum concurrent injections Dupuytren disease fixed flexion contracture range of motion DISEASE

Citationsformater