The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial

Christine Marie Bækø Halling*, Morten Hylander Møller, Søren Marker, Mette Krag, Jakob Kjellberg, Anders Perner, Dorte Gyrd-Hansen

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Purpose: Patients in intensive care units (ICUs) are at risk of stress-related gastrointestinal (GI) bleeding and stress ulcer prophylaxis (SUP), including proton pump inhibitors, is widely used in the attempt to prevent this. In this secondary analysis of Stress Ulcer Prophylaxis in Intensive Care Unit (SUP-ICU) trial, we assessed 1-year outcomes in the pantoprazole vs. placebo groups. Methods: In the SUP-ICU trial, 3298 acutely admitted ICU patients at risk of GI bleeding were randomly allocated, stratified for site, to pantoprazole or placebo. In this secondary analysis, we assessed clinically important GI bleedings in ICU and 1-year mortality, health care resource use (e.g. readmission with GI bleeding, use of home care and general practitioner), health care costs, and employment status for the Danish participants using registry data. Results: Among the 2099 Danish participants, 2092 had data in the registries; 1045 allocated to pantoprazole and 1047 to placebo. The number of clinically important GI bleedings in ICU was 1.9 percentage points [95% CI 0.3–3.5] lower in the pantoprazole group vs. the placebo group, but none of the 1-year outcomes differed statistically significantly between groups, including total health care costs (€1954 [− 2992 to 6899]), readmission with GI bleeding (− 0.005 admissions [− 0.016 to 0.005]), 1-year mortality (− 0.013 percentage points [− 0.051 to 0.026]), and employment (− 0.178 weeks [− 0.390 to 0.034]). Conclusion: Among ICU patients at risk of GI bleeding, pantoprazole reduced clinically important GI bleeding in ICU, but this did not translate into a reduction in 1-year mortality, health care resource use or improvements in employment status.

OriginalsprogEngelsk
TidsskriftIntensive Care Medicine
Vol/bind48
Udgave nummer4
Sider (fra-til)426-434
ISSN0342-4642
DOI
StatusUdgivet - apr. 2022

Bibliografisk note

Funding Information:
Innovation Fund Denmark funded the research described in this paper. The paper has benefitted greatly from discussions with the SUP-ICU trial group. Any errors are the responsibility of the authors. We are grateful to all participating patients and their relatives.

Publisher Copyright:
© 2022, Springer-Verlag GmbH Germany, part of Springer Nature.

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