Aim. - This study aimed to assess whether group-based lifestyle counselling offered to a high-risk population subgroup had any effect beyond individual multi factorial interventions on fasting plasma glucose (FPG) and 2-h plasma glucose (2hPG) changes. Methods. - In a population-based study of 6784 participants, 4053 were determined to be at high risk based on a risk estimate of ischaemic heart disease or the presence of risk factors (smoking, hypertension, hypercholesterolaemia, obesity, impaired glucose tolerance). Of these subjects, 90% were randomized to high-intensity intervention (group A) and 10% to low-intensity intervention (group B). All participants went through health examinations, risk assessments and individual lifestyle counselling. Participants in group A were further offered group-based lifestyle counselling. The intervention was repeated after 1 and 3 years. A total of 2738 participants free of diabetes at baseline (1999-2001) and with at least one FPG and/or 2hPG measurement during 5 years of follow-up were included in the analyses. Differences in changes of plasma glucose between groups A and B were analyzed using multilevel linear regression. Results. - For FPG, crude 5-year changes were significantly different between the two groups (group A: -0.003 mmol/L vs group B: -0.079 mmol/L; P=0.0427). After adjusting for relevant confounders, no differences in FPG changes were observed (P=0.116). Also, no significant differences in the 5-year changes in 2hPG between the two groups were observed (group A: - 0.127 mmol/L vs group B: -0.201 mmol/L; P=0.546). Conclusion. - Offering additional group-based intervention to a high-risk population subgroup had no clinical effects on changes in plasma glucose beyond those of individualized multifactorial interventions. (C) 2011 Elsevier Masson SAS. All rights reserved.
Lau, C., Vistisen, D., Toft, U., Tetens, I., Glumer, C., Pedersen, O., Jorgensen, T., & Borch-Johnsen, K. (2011). The effects of adding group-based lifestyle counselling to individual counselling on changes in plasma glucose levels in a randomized controlled trial: The Inter99 study. Diabetes & Metabolism, 37(6), 546-552. https://doi.org/10.1016/j.diabet.2011.06.001