The effectiveness of exercise-based rehabilitation to patients with myeloproliferative neoplasms—An explorative study

Kasper Mønsted Pedersen*, Graziella Zangger, Nana Brochmann, Birk Mygind Grønfeldt, Ann Dorthe Zwisler, Hans Carl Hasselbalch, Lars Hermann Tang

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The aim of the study was to determine the impact of an interdisciplinary exercise-based rehabilitation intervention on fatigue and quality of life (QOL) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs). At the Danish Knowledge Centre for Rehabilitation and Palliative Care, a 5-day interdisciplinary exercise-based rehabilitation intervention was carried out on 48 patients with MPN. It was followed by 12 weeks of self-exercising prior to follow-up. Initially and at follow-up, participants filled out validated questionnaires; Brief Fatigue Inventory, Multidimensional Fatigue Inventory, European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire, Myeloproliferative Neoplasm Symptom Assessment Form and Hospital Anxiety and Depression Scale. Maximal oxygen uptake and muscular strength were tested as well. Paired t test was used to compare scores between baseline and follow-up. In total, 45 participants (94%) completed the follow-up. No significant differences were observed on fatigue or QOL when comparing baseline and follow-up. Mean maximal oxygen uptake increased from 27.2 to 33.6 ml O2 · kg−1 ·min−1 (p < 0.001). Handgrip strength (p = 0.01) and the 30-s chair-stand test (p < 0.001) improved as well. No changes were found regarding levels of fatigue and QOL. However, we observed a significant increase in the physical capacity. Our observations call for further studies investigating the effects of non-pharmacological approaches in patients with MPN.

OriginalsprogEngelsk
Artikelnummere12865
TidsskriftEuropean Journal of Cancer Care
Vol/bind27
Udgave nummer5
Antal sider10
ISSN0961-5423
DOI
StatusUdgivet - 1. sep. 2018

Fingeraftryk

Quality of Life
Neoplasms
Oxygen
Equipment and Supplies
Rehabilitation Centers
Palliative Care
Organizations
Depression
Research
Surveys and Questionnaires

Citer dette

Pedersen, Kasper Mønsted ; Zangger, Graziella ; Brochmann, Nana ; Grønfeldt, Birk Mygind ; Zwisler, Ann Dorthe ; Hasselbalch, Hans Carl ; Tang, Lars Hermann. / The effectiveness of exercise-based rehabilitation to patients with myeloproliferative neoplasms—An explorative study. I: European Journal of Cancer Care. 2018 ; Bind 27, Nr. 5.
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abstract = "The aim of the study was to determine the impact of an interdisciplinary exercise-based rehabilitation intervention on fatigue and quality of life (QOL) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs). At the Danish Knowledge Centre for Rehabilitation and Palliative Care, a 5-day interdisciplinary exercise-based rehabilitation intervention was carried out on 48 patients with MPN. It was followed by 12 weeks of self-exercising prior to follow-up. Initially and at follow-up, participants filled out validated questionnaires; Brief Fatigue Inventory, Multidimensional Fatigue Inventory, European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire, Myeloproliferative Neoplasm Symptom Assessment Form and Hospital Anxiety and Depression Scale. Maximal oxygen uptake and muscular strength were tested as well. Paired t test was used to compare scores between baseline and follow-up. In total, 45 participants (94{\%}) completed the follow-up. No significant differences were observed on fatigue or QOL when comparing baseline and follow-up. Mean maximal oxygen uptake increased from 27.2 to 33.6 ml O2 · kg−1 ·min−1 (p < 0.001). Handgrip strength (p = 0.01) and the 30-s chair-stand test (p < 0.001) improved as well. No changes were found regarding levels of fatigue and QOL. However, we observed a significant increase in the physical capacity. Our observations call for further studies investigating the effects of non-pharmacological approaches in patients with MPN.",
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The effectiveness of exercise-based rehabilitation to patients with myeloproliferative neoplasms—An explorative study. / Pedersen, Kasper Mønsted; Zangger, Graziella; Brochmann, Nana; Grønfeldt, Birk Mygind; Zwisler, Ann Dorthe; Hasselbalch, Hans Carl; Tang, Lars Hermann.

I: European Journal of Cancer Care, Bind 27, Nr. 5, e12865, 01.09.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The effectiveness of exercise-based rehabilitation to patients with myeloproliferative neoplasms—An explorative study

AU - Pedersen, Kasper Mønsted

AU - Zangger, Graziella

AU - Brochmann, Nana

AU - Grønfeldt, Birk Mygind

AU - Zwisler, Ann Dorthe

AU - Hasselbalch, Hans Carl

AU - Tang, Lars Hermann

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The aim of the study was to determine the impact of an interdisciplinary exercise-based rehabilitation intervention on fatigue and quality of life (QOL) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs). At the Danish Knowledge Centre for Rehabilitation and Palliative Care, a 5-day interdisciplinary exercise-based rehabilitation intervention was carried out on 48 patients with MPN. It was followed by 12 weeks of self-exercising prior to follow-up. Initially and at follow-up, participants filled out validated questionnaires; Brief Fatigue Inventory, Multidimensional Fatigue Inventory, European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire, Myeloproliferative Neoplasm Symptom Assessment Form and Hospital Anxiety and Depression Scale. Maximal oxygen uptake and muscular strength were tested as well. Paired t test was used to compare scores between baseline and follow-up. In total, 45 participants (94%) completed the follow-up. No significant differences were observed on fatigue or QOL when comparing baseline and follow-up. Mean maximal oxygen uptake increased from 27.2 to 33.6 ml O2 · kg−1 ·min−1 (p < 0.001). Handgrip strength (p = 0.01) and the 30-s chair-stand test (p < 0.001) improved as well. No changes were found regarding levels of fatigue and QOL. However, we observed a significant increase in the physical capacity. Our observations call for further studies investigating the effects of non-pharmacological approaches in patients with MPN.

AB - The aim of the study was to determine the impact of an interdisciplinary exercise-based rehabilitation intervention on fatigue and quality of life (QOL) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs). At the Danish Knowledge Centre for Rehabilitation and Palliative Care, a 5-day interdisciplinary exercise-based rehabilitation intervention was carried out on 48 patients with MPN. It was followed by 12 weeks of self-exercising prior to follow-up. Initially and at follow-up, participants filled out validated questionnaires; Brief Fatigue Inventory, Multidimensional Fatigue Inventory, European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire, Myeloproliferative Neoplasm Symptom Assessment Form and Hospital Anxiety and Depression Scale. Maximal oxygen uptake and muscular strength were tested as well. Paired t test was used to compare scores between baseline and follow-up. In total, 45 participants (94%) completed the follow-up. No significant differences were observed on fatigue or QOL when comparing baseline and follow-up. Mean maximal oxygen uptake increased from 27.2 to 33.6 ml O2 · kg−1 ·min−1 (p < 0.001). Handgrip strength (p = 0.01) and the 30-s chair-stand test (p < 0.001) improved as well. No changes were found regarding levels of fatigue and QOL. However, we observed a significant increase in the physical capacity. Our observations call for further studies investigating the effects of non-pharmacological approaches in patients with MPN.

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KW - fatigue

KW - myeloproliferative neoplasms

KW - non-pharmacological interventions

KW - quality of life

KW - rehabilitation

KW - Neoplasms/physiopathology

KW - Humans

KW - Middle Aged

KW - Muscle Strength/physiology

KW - Depression/prevention & control

KW - Male

KW - Hand Strength/physiology

KW - Quality of Life

KW - Adult

KW - Anxiety/prevention & control

KW - Female

KW - Aged

KW - Exercise Therapy/methods

KW - Myeloproliferative Disorders/physiopathology

KW - Fatigue/prevention & control

U2 - 10.1111/ecc.12865

DO - 10.1111/ecc.12865

M3 - Journal article

C2 - 29888803

AN - SCOPUS:85053828601

VL - 27

JO - European Journal of Cancer Care

JF - European Journal of Cancer Care

SN - 0961-5423

IS - 5

M1 - e12865

ER -