The Effectiveness of a Very Low-Volume Compared to High-Volume Laxative in Colon Capsule Endoscopy

Benedicte Schelde-Olesen; Artur Nemeth; Gabriele Wurm Johansson; Ulrik Deding; Thomas Bjørsum-Meyer; Henrik Thorlacius; Gunnar Baatrup; Anastasios Koulaouzidis; Ervin Toth

doi:10.3390/diagnostics13010018

The Effectiveness of a Very Low-Volume Compared to High-Volume Laxative in Colon Capsule Endoscopy

Benedicte Schelde-Olesen^*
, Artur Nemeth
, Gabriele Wurm Johansson
, Ulrik Deding
, Thomas Bjørsum-Meyer
, Henrik Thorlacius
, Gunnar Baatrup
, Anastasios Koulaouzidis
, Ervin Toth

^*Kontaktforfatter

Skåne University Hospital
Pomeranian Medical University

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Colon capsule endoscopy (CCE) is a promising modality for colonic investigations, but completion rates (CR) and adequate cleansing rates (ACR) must be improved to meet established standards for optical colonoscopy. Improvements should be made with patient acceptability in mind. We aimed to compare a very low-volume polyethylene glycol (PEG) laxative to a conventional high-volume laxative. We carried out a single-center retrospective comparative cohort study including patients referred for CCE. One hundred and sixty-six patients were included in the final analysis, with eighty-three patients in each group. We found a CR and ACR of 77% and 67% in the high-volume group and 72% and 75% in the very low-volume group, respectively. In the high-volume group, 54% had complete transit and adequate cleansing, whereas this was the case for 63% in the very low-volume group. No statistically significant difference in CR, ACR, or a combination of the two was found. A very low-volume bowel preparation regimen was non-inferior to a high-volume regimen before CCE in terms of CR and ACR.

Originalsprog	Engelsk
Artikelnummer	18
Tidsskrift	Diagnostics
Vol/bind	13
Udgave nummer	1
Antal sider	9
ISSN	2075-4418
DOI	https://doi.org/10.3390/diagnostics13010018
Status	Udgivet - jan. 2023

Bibliografisk note

Funding Information:
This research was funded by the Swedish Cancer Society, grant number 19 0386.

Funding Information:
Ervin Toth has received research support and consultancy fees from Medtronic, Olympus, AnX Robotica and Norgine. Anastasios Koulaouzidis is co-director and shareholder of iCERV Ltd. He has received consultancy fees and travel support from Jinshan Ltd., Diagmed Healthcare Ltd. and research support (grant) from ESGE/Given Imaging Ltd. and IntroMedic/SynMed, honoraria from Jinshan and Medtronic and has participated in advisory board meetings hosted by ANKON.

Finansiering

This research was funded by the Swedish Cancer Society, grant number 19 0386. Ervin Toth has received research support and consultancy fees from Medtronic, Olympus, AnX Robotica and Norgine. Anastasios Koulaouzidis is co-director and shareholder of iCERV Ltd. He has received consultancy fees and travel support from Jinshan Ltd., Diagmed Healthcare Ltd. and research support (grant) from ESGE/Given Imaging Ltd. and IntroMedic/SynMed, honoraria from Jinshan and Medtronic and has participated in advisory board meetings hosted by ANKON.

Dokumenter og links

10.3390/diagnostics13010018Licens: CC BY

Open Access VersionForlagets udgivne version, 824 KBLicens: CC BY

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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abstract = "Colon capsule endoscopy (CCE) is a promising modality for colonic investigations, but completion rates (CR) and adequate cleansing rates (ACR) must be improved to meet established standards for optical colonoscopy. Improvements should be made with patient acceptability in mind. We aimed to compare a very low-volume polyethylene glycol (PEG) laxative to a conventional high-volume laxative. We carried out a single-center retrospective comparative cohort study including patients referred for CCE. One hundred and sixty-six patients were included in the final analysis, with eighty-three patients in each group. We found a CR and ACR of 77\% and 67\% in the high-volume group and 72\% and 75\% in the very low-volume group, respectively. In the high-volume group, 54\% had complete transit and adequate cleansing, whereas this was the case for 63\% in the very low-volume group. No statistically significant difference in CR, ACR, or a combination of the two was found. A very low-volume bowel preparation regimen was non-inferior to a high-volume regimen before CCE in terms of CR and ACR.",

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AU - Schelde-Olesen, Benedicte

AU - Nemeth, Artur

AU - Johansson, Gabriele Wurm

AU - Deding, Ulrik

AU - Bjørsum-Meyer, Thomas

AU - Thorlacius, Henrik

AU - Baatrup, Gunnar

AU - Koulaouzidis, Anastasios

AU - Toth, Ervin

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N2 - Colon capsule endoscopy (CCE) is a promising modality for colonic investigations, but completion rates (CR) and adequate cleansing rates (ACR) must be improved to meet established standards for optical colonoscopy. Improvements should be made with patient acceptability in mind. We aimed to compare a very low-volume polyethylene glycol (PEG) laxative to a conventional high-volume laxative. We carried out a single-center retrospective comparative cohort study including patients referred for CCE. One hundred and sixty-six patients were included in the final analysis, with eighty-three patients in each group. We found a CR and ACR of 77% and 67% in the high-volume group and 72% and 75% in the very low-volume group, respectively. In the high-volume group, 54% had complete transit and adequate cleansing, whereas this was the case for 63% in the very low-volume group. No statistically significant difference in CR, ACR, or a combination of the two was found. A very low-volume bowel preparation regimen was non-inferior to a high-volume regimen before CCE in terms of CR and ACR.

AB - Colon capsule endoscopy (CCE) is a promising modality for colonic investigations, but completion rates (CR) and adequate cleansing rates (ACR) must be improved to meet established standards for optical colonoscopy. Improvements should be made with patient acceptability in mind. We aimed to compare a very low-volume polyethylene glycol (PEG) laxative to a conventional high-volume laxative. We carried out a single-center retrospective comparative cohort study including patients referred for CCE. One hundred and sixty-six patients were included in the final analysis, with eighty-three patients in each group. We found a CR and ACR of 77% and 67% in the high-volume group and 72% and 75% in the very low-volume group, respectively. In the high-volume group, 54% had complete transit and adequate cleansing, whereas this was the case for 63% in the very low-volume group. No statistically significant difference in CR, ACR, or a combination of the two was found. A very low-volume bowel preparation regimen was non-inferior to a high-volume regimen before CCE in terms of CR and ACR.

KW - bowel cleansing quality

KW - bowel preparation

KW - capsule endoscopy

KW - completion rate

U2 - 10.3390/diagnostics13010018

DO - 10.3390/diagnostics13010018

M3 - Journal article

C2 - 36611310

AN - SCOPUS:85145841711

SN - 2075-4418

VL - 13

JO - Diagnostics

JF - Diagnostics

IS - 1

M1 - 18

ER -

The Effectiveness of a Very Low-Volume Compared to High-Volume Laxative in Colon Capsule Endoscopy

Abstract

Bibliografisk note

Finansiering

Dokumenter og links

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Fingeraftryk

Citationsformater