The effect of tumor laterality on survival for non-small cell lung cancer patients treated with radiotherapy

Nicolai Jørgensen, Eric Leif Meline, Stefan Starup Jeppesen, Olfred Hansen, Morten Nielsen, Tine Schytte

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Abstrakt

Background: The treatment of choice for patients with locally advanced non-small cell lung cancer (LA-NSCLC) in good performance status is definitive radiotherapy (RT), the five-year survival being approximately 25-30%. Advances in the diagnostic procedures and treatment modalities in NSCLC have increased the overall survival, making identifying factors with impact on survival increasingly relevant. Recent research indicates that tumor laterality has impact on the survival of patients with LA-NSCLC treated with definitive RT. The aim of this study was to investigate whether tumor laterality impacted overall survival. Material and methods: All patients with stage IIa-IIIb NSCLC planned for curative intended RT from 2008 to 2013 at Odense University Hospital were analyzed to compare overall survival of patients with right-sided vs. left-sided tumors. Log-rank test was performed to test for differences in survival rates and Cox regression analyses to test for possible confounders. No patients were lost to follow-up. Results: In total, 164 patients had a tumor in the right lung and 118 had tumor in the left lung. All patients had at least 4.5 years' follow-up. Median overall survival was 19 months (right) and 22.5 months (left) p = .729. Three-year overall survival was 31% (right) and 35% (left). In Cox regression analyses age, performances status and total mean lung dose were statistically significant with a hazard ratio (HR) = 1.03 (95% Cl: 1.01-1.05), HR = 1.60 (95% Cl: 1.12-2.28), and HR = 1.11 (95% Cl: 1.06-1.16), respectively. Conclusion: This study did not verify that laterality has a significant impact on survival in LA-NSCLC patients treated with curative intended RT.

OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind58
Udgave nummer10
Sider (fra-til)1393-1398
ISSN0284-186X
DOI
StatusUdgivet - 2019
Begivenhed18th Acta Oncologica Symposium: Biology-Guided Adaptive Radiotherapy - Aarhus, Danmark
Varighed: 22. maj 201924. maj 2019

Konference

Konference18th Acta Oncologica Symposium
LandDanmark
ByAarhus
Periode22/05/201924/05/2019

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