The effect of metrizamide on regional brain glucose metabolism in the rat

L Bech, N H Diemer, A Gjedde

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Abstrakt

The X-ray contrast material metrizamide is structurally related to 2-deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2-deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.

OriginalsprogEngelsk
BogserieActa Neurologica Scandinavica
Vol/bind69
Udgave nummer4
Sider (fra-til)249-53
ISSN0001-6314
DOI
StatusUdgivet - apr. 1984
Udgivet eksterntJa

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