The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment

Julie T Kloppenborg, Michael Gamborg, Cilius E Fonvig, Tenna R H Nielsen, Oluf Pedersen, Jesper Johannesen, Torben Hansen, Jens-Christian Holm

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: To investigate whether children and adolescents exhibiting an impaired glucose metabolism are more obese at treatment entry and less likely to reduce their degree of obesity during treatment.

METHODS: The present study is a longitudinal observational study, including children and adolescents from the Children's Obesity Clinic, Holbaek, Denmark. Anthropometrics, pubertal development, socioeconomic status (SES), and fasting concentrations of plasma glucose, serum insulin, serum C-peptide, and whole blood glycosylated hemoglobin (HbA1c) were collected at treatment entry and at follow-up. Proxies of Homeostasis Model Assessment 2-insulin sensitivity (HOMA2-IS) and Homeostasis Model Assessment 2-β-cell function (HOMA2-B) were calculated with the Homeostasis Model Assessment 2 program.

RESULTS: In total, 569 (333 boys) patients, median 11.5 years of age (range 6-22 years), and median body mass index (BMI) z-score 2.94 (range 1.34-5.54) were included. The mean BMI z-score reduction was 0.31 (±0.46) after 13 months (range 6-18) of treatment. At treatment entry, patients with impaired estimates of glucose metabolism were more obese than normoglycemic patients. Baseline concentration of C-peptide was associated with a lower weight loss during treatment in girls (P = .02). Reduction in the insulin concentrations was associated with reduction in BMI z-score in both sexes (P < .0001, P = .0005). During treatment, values of glucose, HbA1c, HOMA2-IS, and HOMA2-B did not change or impact the treatment outcome, regardless of age, sex, SES, or degree of obesity at treatment entry.

CONCLUSION: The capability to reduce weight during multidisciplinary treatment in children and adolescents with overweight/obesity is not influenced by an impaired glucose metabolism at study entry or during the course of treatment.

OriginalsprogEngelsk
TidsskriftPediatric Diabetes
Vol/bind19
Udgave nummer3
Sider (fra-til)366-374
ISSN1399-543X
DOI
StatusUdgivet - maj 2018

Fingeraftryk

Pediatric Obesity
Homeostasis
Body Mass Index
Insulin Resistance
Insulin
Glycosylated Hemoglobin A
Proxy
Denmark
Serum
Longitudinal Studies
Fasting
Weights and Measures

Citer dette

Kloppenborg, J. T., Gamborg, M., Fonvig, C. E., Nielsen, T. R. H., Pedersen, O., Johannesen, J., ... Holm, J-C. (2018). The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment. Pediatric Diabetes, 19(3), 366-374. https://doi.org/10.1111/pedi.12605
Kloppenborg, Julie T ; Gamborg, Michael ; Fonvig, Cilius E ; Nielsen, Tenna R H ; Pedersen, Oluf ; Johannesen, Jesper ; Hansen, Torben ; Holm, Jens-Christian. / The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment. I: Pediatric Diabetes. 2018 ; Bind 19, Nr. 3. s. 366-374.
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abstract = "OBJECTIVE: To investigate whether children and adolescents exhibiting an impaired glucose metabolism are more obese at treatment entry and less likely to reduce their degree of obesity during treatment.METHODS: The present study is a longitudinal observational study, including children and adolescents from the Children's Obesity Clinic, Holbaek, Denmark. Anthropometrics, pubertal development, socioeconomic status (SES), and fasting concentrations of plasma glucose, serum insulin, serum C-peptide, and whole blood glycosylated hemoglobin (HbA1c) were collected at treatment entry and at follow-up. Proxies of Homeostasis Model Assessment 2-insulin sensitivity (HOMA2-IS) and Homeostasis Model Assessment 2-β-cell function (HOMA2-B) were calculated with the Homeostasis Model Assessment 2 program.RESULTS: In total, 569 (333 boys) patients, median 11.5 years of age (range 6-22 years), and median body mass index (BMI) z-score 2.94 (range 1.34-5.54) were included. The mean BMI z-score reduction was 0.31 (±0.46) after 13 months (range 6-18) of treatment. At treatment entry, patients with impaired estimates of glucose metabolism were more obese than normoglycemic patients. Baseline concentration of C-peptide was associated with a lower weight loss during treatment in girls (P = .02). Reduction in the insulin concentrations was associated with reduction in BMI z-score in both sexes (P < .0001, P = .0005). During treatment, values of glucose, HbA1c, HOMA2-IS, and HOMA2-B did not change or impact the treatment outcome, regardless of age, sex, SES, or degree of obesity at treatment entry.CONCLUSION: The capability to reduce weight during multidisciplinary treatment in children and adolescents with overweight/obesity is not influenced by an impaired glucose metabolism at study entry or during the course of treatment.",
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Kloppenborg, JT, Gamborg, M, Fonvig, CE, Nielsen, TRH, Pedersen, O, Johannesen, J, Hansen, T & Holm, J-C 2018, 'The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment', Pediatric Diabetes, bind 19, nr. 3, s. 366-374. https://doi.org/10.1111/pedi.12605

The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment. / Kloppenborg, Julie T; Gamborg, Michael; Fonvig, Cilius E; Nielsen, Tenna R H; Pedersen, Oluf; Johannesen, Jesper; Hansen, Torben; Holm, Jens-Christian.

I: Pediatric Diabetes, Bind 19, Nr. 3, 05.2018, s. 366-374.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment

AU - Kloppenborg, Julie T

AU - Gamborg, Michael

AU - Fonvig, Cilius E

AU - Nielsen, Tenna R H

AU - Pedersen, Oluf

AU - Johannesen, Jesper

AU - Hansen, Torben

AU - Holm, Jens-Christian

N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2018/5

Y1 - 2018/5

N2 - OBJECTIVE: To investigate whether children and adolescents exhibiting an impaired glucose metabolism are more obese at treatment entry and less likely to reduce their degree of obesity during treatment.METHODS: The present study is a longitudinal observational study, including children and adolescents from the Children's Obesity Clinic, Holbaek, Denmark. Anthropometrics, pubertal development, socioeconomic status (SES), and fasting concentrations of plasma glucose, serum insulin, serum C-peptide, and whole blood glycosylated hemoglobin (HbA1c) were collected at treatment entry and at follow-up. Proxies of Homeostasis Model Assessment 2-insulin sensitivity (HOMA2-IS) and Homeostasis Model Assessment 2-β-cell function (HOMA2-B) were calculated with the Homeostasis Model Assessment 2 program.RESULTS: In total, 569 (333 boys) patients, median 11.5 years of age (range 6-22 years), and median body mass index (BMI) z-score 2.94 (range 1.34-5.54) were included. The mean BMI z-score reduction was 0.31 (±0.46) after 13 months (range 6-18) of treatment. At treatment entry, patients with impaired estimates of glucose metabolism were more obese than normoglycemic patients. Baseline concentration of C-peptide was associated with a lower weight loss during treatment in girls (P = .02). Reduction in the insulin concentrations was associated with reduction in BMI z-score in both sexes (P < .0001, P = .0005). During treatment, values of glucose, HbA1c, HOMA2-IS, and HOMA2-B did not change or impact the treatment outcome, regardless of age, sex, SES, or degree of obesity at treatment entry.CONCLUSION: The capability to reduce weight during multidisciplinary treatment in children and adolescents with overweight/obesity is not influenced by an impaired glucose metabolism at study entry or during the course of treatment.

AB - OBJECTIVE: To investigate whether children and adolescents exhibiting an impaired glucose metabolism are more obese at treatment entry and less likely to reduce their degree of obesity during treatment.METHODS: The present study is a longitudinal observational study, including children and adolescents from the Children's Obesity Clinic, Holbaek, Denmark. Anthropometrics, pubertal development, socioeconomic status (SES), and fasting concentrations of plasma glucose, serum insulin, serum C-peptide, and whole blood glycosylated hemoglobin (HbA1c) were collected at treatment entry and at follow-up. Proxies of Homeostasis Model Assessment 2-insulin sensitivity (HOMA2-IS) and Homeostasis Model Assessment 2-β-cell function (HOMA2-B) were calculated with the Homeostasis Model Assessment 2 program.RESULTS: In total, 569 (333 boys) patients, median 11.5 years of age (range 6-22 years), and median body mass index (BMI) z-score 2.94 (range 1.34-5.54) were included. The mean BMI z-score reduction was 0.31 (±0.46) after 13 months (range 6-18) of treatment. At treatment entry, patients with impaired estimates of glucose metabolism were more obese than normoglycemic patients. Baseline concentration of C-peptide was associated with a lower weight loss during treatment in girls (P = .02). Reduction in the insulin concentrations was associated with reduction in BMI z-score in both sexes (P < .0001, P = .0005). During treatment, values of glucose, HbA1c, HOMA2-IS, and HOMA2-B did not change or impact the treatment outcome, regardless of age, sex, SES, or degree of obesity at treatment entry.CONCLUSION: The capability to reduce weight during multidisciplinary treatment in children and adolescents with overweight/obesity is not influenced by an impaired glucose metabolism at study entry or during the course of treatment.

KW - Adolescent

KW - Blood Glucose

KW - Body Mass Index

KW - C-Peptide/blood

KW - Child

KW - Female

KW - Glucose Intolerance/blood

KW - Glycated Hemoglobin A/metabolism

KW - Humans

KW - Insulin/blood

KW - Longitudinal Studies

KW - Male

KW - Pediatric Obesity/blood

KW - Prediabetic State/blood

KW - Weight Loss

KW - Weight Reduction Programs/statistics & numerical data

KW - Young Adult

U2 - 10.1111/pedi.12605

DO - 10.1111/pedi.12605

M3 - Journal article

VL - 19

SP - 366

EP - 374

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 3

ER -

Kloppenborg JT, Gamborg M, Fonvig CE, Nielsen TRH, Pedersen O, Johannesen J et al. The effect of impaired glucose metabolism on weight loss in multidisciplinary childhood obesity treatment. Pediatric Diabetes. 2018 maj;19(3):366-374. https://doi.org/10.1111/pedi.12605