The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes

Katrine Hygum*, Jakob Starup-Linde, Torben Harsløf, Niklas Rye Jørgensen, Bolette Hartmann, Jens Juul Holst, Bente L. Langdahl

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: Bone turnover has a diurnal variation influenced by food intake, incretin hormones, the sympathetic nervous system and osteocyte function. The aim of the study was to compare diurnal variation in bone turnover in patients with diabetes and controls. Design: A clinical 24-h study with patients with type 1 diabetes (n = 5), patients with type 2 diabetes (n = 5) and controls (n = 5). Methods: Inclusion criterion: age >50 years. Exclusion criteria: diseases/medication that affect bone metabolism or recent use of incretin-based drugs. We drew blood samples hourly during the day and every 3 h during the night. We served an identical diet on all study days. We used repeated-measures one-way ANOVA to compare the levels of the investigated markers, and we quantified the effect of time by comparing group mean standard deviations. Results: The bone formation marker procollagen type 1 N-terminal propeptide showed a significant interaction between time and group (P = 0.01), and the mean standard deviation was lower in patients with type 2 diabetes compared with controls (P = 0.04) and patients with type 1 diabetes (P = 0.02). Other markers of bone formation and resorption showed significant effect of time. Levels of glucagon-like peptide-2, glucose-dependent insulinotropic peptide and sclerostin only showed significant effect of time (all P values 0.01), but levels of sclerostin tended to being highest in type 2 diabetes and lowest in controls. Conclusions: The diurnal variation in bone formation is attenuated in patients with type 2 diabetes. This is not explained by changes in incretin hormone levels, but possibly mediated by sclerostin.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind181
Udgave nummer3
Sider (fra-til)221-231
ISSN0804-4643
DOI
StatusUdgivet - sep. 2019

Fingeraftryk

Osteogenesis
Type 2 Diabetes Mellitus
Glucagon-Like Peptide 2
Gastric Inhibitory Polypeptide
Hormones
Osteocytes
Collagen Type I
Diet
Pharmaceutical Preparations

Citer dette

Hygum, K., Starup-Linde, J., Harsløf, T., Jørgensen, N. R., Hartmann, B., Holst, J. J., & Langdahl, B. L. (2019). The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes. European Journal of Endocrinology, 181(3), 221-231. https://doi.org/10.1530/EJE-19-0309
Hygum, Katrine ; Starup-Linde, Jakob ; Harsløf, Torben ; Jørgensen, Niklas Rye ; Hartmann, Bolette ; Holst, Jens Juul ; Langdahl, Bente L. / The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes. I: European Journal of Endocrinology. 2019 ; Bind 181, Nr. 3. s. 221-231.
@article{29e62f5f6f0f427ea5e869233143801f,
title = "The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes",
abstract = "Objective: Bone turnover has a diurnal variation influenced by food intake, incretin hormones, the sympathetic nervous system and osteocyte function. The aim of the study was to compare diurnal variation in bone turnover in patients with diabetes and controls. Design: A clinical 24-h study with patients with type 1 diabetes (n = 5), patients with type 2 diabetes (n = 5) and controls (n = 5). Methods: Inclusion criterion: age >50 years. Exclusion criteria: diseases/medication that affect bone metabolism or recent use of incretin-based drugs. We drew blood samples hourly during the day and every 3 h during the night. We served an identical diet on all study days. We used repeated-measures one-way ANOVA to compare the levels of the investigated markers, and we quantified the effect of time by comparing group mean standard deviations. Results: The bone formation marker procollagen type 1 N-terminal propeptide showed a significant interaction between time and group (P = 0.01), and the mean standard deviation was lower in patients with type 2 diabetes compared with controls (P = 0.04) and patients with type 1 diabetes (P = 0.02). Other markers of bone formation and resorption showed significant effect of time. Levels of glucagon-like peptide-2, glucose-dependent insulinotropic peptide and sclerostin only showed significant effect of time (all P values 0.01), but levels of sclerostin tended to being highest in type 2 diabetes and lowest in controls. Conclusions: The diurnal variation in bone formation is attenuated in patients with type 2 diabetes. This is not explained by changes in incretin hormone levels, but possibly mediated by sclerostin.",
author = "Katrine Hygum and Jakob Starup-Linde and Torben Harsl{\o}f and J{\o}rgensen, {Niklas Rye} and Bolette Hartmann and Holst, {Jens Juul} and Langdahl, {Bente L.}",
year = "2019",
month = "9",
doi = "10.1530/EJE-19-0309",
language = "English",
volume = "181",
pages = "221--231",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "3",

}

Hygum, K, Starup-Linde, J, Harsløf, T, Jørgensen, NR, Hartmann, B, Holst, JJ & Langdahl, BL 2019, 'The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes', European Journal of Endocrinology, bind 181, nr. 3, s. 221-231. https://doi.org/10.1530/EJE-19-0309

The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes. / Hygum, Katrine; Starup-Linde, Jakob; Harsløf, Torben; Jørgensen, Niklas Rye; Hartmann, Bolette; Holst, Jens Juul; Langdahl, Bente L.

I: European Journal of Endocrinology, Bind 181, Nr. 3, 09.2019, s. 221-231.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes

AU - Hygum, Katrine

AU - Starup-Linde, Jakob

AU - Harsløf, Torben

AU - Jørgensen, Niklas Rye

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Langdahl, Bente L.

PY - 2019/9

Y1 - 2019/9

N2 - Objective: Bone turnover has a diurnal variation influenced by food intake, incretin hormones, the sympathetic nervous system and osteocyte function. The aim of the study was to compare diurnal variation in bone turnover in patients with diabetes and controls. Design: A clinical 24-h study with patients with type 1 diabetes (n = 5), patients with type 2 diabetes (n = 5) and controls (n = 5). Methods: Inclusion criterion: age >50 years. Exclusion criteria: diseases/medication that affect bone metabolism or recent use of incretin-based drugs. We drew blood samples hourly during the day and every 3 h during the night. We served an identical diet on all study days. We used repeated-measures one-way ANOVA to compare the levels of the investigated markers, and we quantified the effect of time by comparing group mean standard deviations. Results: The bone formation marker procollagen type 1 N-terminal propeptide showed a significant interaction between time and group (P = 0.01), and the mean standard deviation was lower in patients with type 2 diabetes compared with controls (P = 0.04) and patients with type 1 diabetes (P = 0.02). Other markers of bone formation and resorption showed significant effect of time. Levels of glucagon-like peptide-2, glucose-dependent insulinotropic peptide and sclerostin only showed significant effect of time (all P values 0.01), but levels of sclerostin tended to being highest in type 2 diabetes and lowest in controls. Conclusions: The diurnal variation in bone formation is attenuated in patients with type 2 diabetes. This is not explained by changes in incretin hormone levels, but possibly mediated by sclerostin.

AB - Objective: Bone turnover has a diurnal variation influenced by food intake, incretin hormones, the sympathetic nervous system and osteocyte function. The aim of the study was to compare diurnal variation in bone turnover in patients with diabetes and controls. Design: A clinical 24-h study with patients with type 1 diabetes (n = 5), patients with type 2 diabetes (n = 5) and controls (n = 5). Methods: Inclusion criterion: age >50 years. Exclusion criteria: diseases/medication that affect bone metabolism or recent use of incretin-based drugs. We drew blood samples hourly during the day and every 3 h during the night. We served an identical diet on all study days. We used repeated-measures one-way ANOVA to compare the levels of the investigated markers, and we quantified the effect of time by comparing group mean standard deviations. Results: The bone formation marker procollagen type 1 N-terminal propeptide showed a significant interaction between time and group (P = 0.01), and the mean standard deviation was lower in patients with type 2 diabetes compared with controls (P = 0.04) and patients with type 1 diabetes (P = 0.02). Other markers of bone formation and resorption showed significant effect of time. Levels of glucagon-like peptide-2, glucose-dependent insulinotropic peptide and sclerostin only showed significant effect of time (all P values 0.01), but levels of sclerostin tended to being highest in type 2 diabetes and lowest in controls. Conclusions: The diurnal variation in bone formation is attenuated in patients with type 2 diabetes. This is not explained by changes in incretin hormone levels, but possibly mediated by sclerostin.

U2 - 10.1530/EJE-19-0309

DO - 10.1530/EJE-19-0309

M3 - Journal article

C2 - 31189129

AN - SCOPUS:85072179546

VL - 181

SP - 221

EP - 231

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 3

ER -

Hygum K, Starup-Linde J, Harsløf T, Jørgensen NR, Hartmann B, Holst JJ et al. The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes. European Journal of Endocrinology. 2019 sep;181(3):221-231. https://doi.org/10.1530/EJE-19-0309