The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars

Thomas Bo Jensen, Dorthe Bartels, Eva Aggerholm Sædder, Birgitte Klindt Poulsen, Stig Ejdrup Andersen, Mette Marie H Christensen, Lars Nielsen, Hanne Rolighed Christensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Purpose: A rapidly increasing use of biological drugs has led to substantial costs. Shift to biosimilars enables considerable reduction of these costs without jeopardizing the treatment of patients, but most countries have extensive possibilities of untapped cost-savings. The aim of this study was to describe the Danish quick and near-complete implementation of the two first TNF inhibitor biosimilars (infliximab and etanercept). Methods: We shed light on the considerations and experiences made during the implementation, and present key figures from the implementation. Results: The infliximab biosimilar constituted 90.6% of the total amount of infliximab four months following patent expiration of the biooriginator. Similar results were seen for etanercept biosimilar. Substantial cost reductions were experienced in the way that e.g. the infliximab-shift reduced cost by two thirds. Conclusion: We believe that a thorough preparation and an organizational setting supporting the implementation is crucial for the successful implementation. This same implementation model will be used for future biosimilars.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Pharmacology
Vol/bind76
Udgave nummer1
Sider (fra-til)35-40
ISSN0031-6970
DOI
StatusUdgivet - jan. 2020

Fingeraftryk

Biosimilar Pharmaceuticals
Cost Savings
Etanercept

Citer dette

Jensen, Thomas Bo ; Bartels, Dorthe ; Sædder, Eva Aggerholm ; Poulsen, Birgitte Klindt ; Andersen, Stig Ejdrup ; Christensen, Mette Marie H ; Nielsen, Lars ; Christensen, Hanne Rolighed. / The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars. I: European Journal of Clinical Pharmacology. 2020 ; Bind 76, Nr. 1. s. 35-40.
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abstract = "Purpose: A rapidly increasing use of biological drugs has led to substantial costs. Shift to biosimilars enables considerable reduction of these costs without jeopardizing the treatment of patients, but most countries have extensive possibilities of untapped cost-savings. The aim of this study was to describe the Danish quick and near-complete implementation of the two first TNF inhibitor biosimilars (infliximab and etanercept). Methods: We shed light on the considerations and experiences made during the implementation, and present key figures from the implementation. Results: The infliximab biosimilar constituted 90.6{\%} of the total amount of infliximab four months following patent expiration of the biooriginator. Similar results were seen for etanercept biosimilar. Substantial cost reductions were experienced in the way that e.g. the infliximab-shift reduced cost by two thirds. Conclusion: We believe that a thorough preparation and an organizational setting supporting the implementation is crucial for the successful implementation. This same implementation model will be used for future biosimilars.",
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The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars. / Jensen, Thomas Bo; Bartels, Dorthe; Sædder, Eva Aggerholm; Poulsen, Birgitte Klindt; Andersen, Stig Ejdrup; Christensen, Mette Marie H; Nielsen, Lars; Christensen, Hanne Rolighed.

I: European Journal of Clinical Pharmacology, Bind 76, Nr. 1, 01.2020, s. 35-40.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars

AU - Jensen, Thomas Bo

AU - Bartels, Dorthe

AU - Sædder, Eva Aggerholm

AU - Poulsen, Birgitte Klindt

AU - Andersen, Stig Ejdrup

AU - Christensen, Mette Marie H

AU - Nielsen, Lars

AU - Christensen, Hanne Rolighed

PY - 2020/1

Y1 - 2020/1

N2 - Purpose: A rapidly increasing use of biological drugs has led to substantial costs. Shift to biosimilars enables considerable reduction of these costs without jeopardizing the treatment of patients, but most countries have extensive possibilities of untapped cost-savings. The aim of this study was to describe the Danish quick and near-complete implementation of the two first TNF inhibitor biosimilars (infliximab and etanercept). Methods: We shed light on the considerations and experiences made during the implementation, and present key figures from the implementation. Results: The infliximab biosimilar constituted 90.6% of the total amount of infliximab four months following patent expiration of the biooriginator. Similar results were seen for etanercept biosimilar. Substantial cost reductions were experienced in the way that e.g. the infliximab-shift reduced cost by two thirds. Conclusion: We believe that a thorough preparation and an organizational setting supporting the implementation is crucial for the successful implementation. This same implementation model will be used for future biosimilars.

AB - Purpose: A rapidly increasing use of biological drugs has led to substantial costs. Shift to biosimilars enables considerable reduction of these costs without jeopardizing the treatment of patients, but most countries have extensive possibilities of untapped cost-savings. The aim of this study was to describe the Danish quick and near-complete implementation of the two first TNF inhibitor biosimilars (infliximab and etanercept). Methods: We shed light on the considerations and experiences made during the implementation, and present key figures from the implementation. Results: The infliximab biosimilar constituted 90.6% of the total amount of infliximab four months following patent expiration of the biooriginator. Similar results were seen for etanercept biosimilar. Substantial cost reductions were experienced in the way that e.g. the infliximab-shift reduced cost by two thirds. Conclusion: We believe that a thorough preparation and an organizational setting supporting the implementation is crucial for the successful implementation. This same implementation model will be used for future biosimilars.

KW - Anti-TNF drugs

KW - Biological drugs

KW - Biosimilars

KW - Non-medical shift

KW - Pharmacoeconomics

U2 - 10.1007/s00228-019-02765-3

DO - 10.1007/s00228-019-02765-3

M3 - Journal article

C2 - 31677117

VL - 76

SP - 35

EP - 40

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

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ER -