The Danish EQ-5D-5L Value Set: A Hybrid Model Using cTTO and DCE Data

Cathrine Elgaard Jensen*, Sabrina Storgaard Sørensen, Claire Gudex, Morten Berg Jensen, Kjeld Møller Pedersen, Lars Holger Ehlers

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Objectives: Quality-adjusted life-years (QALYs) are expected to be used for priority setting of hospital-dispensed medicines in Denmark from 2021. The aim of this study was to develop the first Danish value set for the EQ-5D-5L based on interviews with a representative sample of the Danish adult population. Methods: A nationally representative sample based on age (> 18 years), gender, education, and geographical region was recruited using data provided by Statistics Denmark. Computer-assisted personal interviews were carried out using the EQ-VT 2.1. Respondents each valued ten health states using composite time trade-off (cTTO) and seven health states using discrete-choice experiment (DCE). Different predictive models were explored using cTTO and DCE data alone or in combination as hybrid models. Model performance was assessed using logical consistency. Results: A total of 1014 interviews were included in the analyses. The sample was representative of the Danish adult population, though the sample contained slightly more respondents with higher education than in the general population. Only the heteroscedastic censored hybrid model combining cTTO and DCE data yielded consistent results, and hence was chosen for modelling the final Danish value set. The predicted values ranged from − 0.757 to 1, and anxiety/depression was the dimension assigned most value by respondents. Conclusions: This study established the Danish EQ-5D-5L value set, which represents the preferences of the Danish general population, and is expected to provide key input for healthcare decision-making in a Danish context.

TidsskriftApplied Health Economics and Health Policy
StatusE-pub ahead of print - 2. feb. 2021

Bibliografisk note

Funding Information:
The Danish EQ-5D-5L valuation study has received funding from the EuroQol Research Foundation, The Danish Health Foundation (Helsefonden), Aase og Ejnar Danielsens Fond, the North Denmark Region, and the Department of Business and Management at Aalborg University. Funding for Open Access was provided by the Department of Clinical Medicine, Aalborg University.

Publisher Copyright:
© 2021, The Author(s).

Copyright 2021 Elsevier B.V., All rights reserved.

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