The DanCavas Pilot Study of Multifaceted Screening for Subclinical Cardiovascular Disease in Men and Women Aged 65-74 Years

T V Kvist, Jes Sanddal Lindholt, L M Rasmussen, R Søgaard, Jess Lambrechtsen, Flemming Hald Steffensen, L Frost, M H Olsen, Hans Mickley, Jesper Hallas, G Urbonaviciene, Martin Busk, Kenneth Egstrup, Axel Cosmus Pyndt Diederichsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE/BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD.

METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c. Web based self booking and data management was used to reduce the administrative burden.

RESULTS: Attendance rates were 64.9% (n = 678) and 63.0% (n = 640) for men and women, respectively. In total, 39.7% received a recommendation for medical preventive actions. Prevalence of aneurysms was 12.4% (95% confidence interval [CI] 9.9-14.9) in men and 1.1% (95% CI 0.3-1.9) in women, respectively (p < .001). A CAC score > 400 was found in 37.8% of men and 11.3% of women (p < .001), along with a significant increase in median CAC score with age (p = .03). Peripheral arterial disease was more prevalent in men (18.8%, 95% CI 15.8-21.8) than in women (11.2%, 95% CI 8.7-13.6). No significant differences between the sexes were found with regard to newly discovered AF (men 1.3%, women 0.5%), potential hypertension (men 9.7%, women 11.5%), hypercholesterolemia (men 0.9%, women 1.1%) or diabetes mellitus (men 2.1%, women 1.3%).

CONCLUSION: Owing to the higher prevalence of severe conditions, such as aneurysms and CAC ≥ 400, screening for CVD seemed more prudent in men than women. The attendance rates were acceptable compared with other screening programs and the logistical structure of the screening program proved successful.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Vascular and Endovascular Surgery
Vol/bind53
Udgave nummer1
Sider (fra-til)123-131
ISSN1078-5884
DOI
StatusUdgivet - 1. jan. 2017

Fingeraftryk

Confidence Intervals
Iliac Aneurysm
Hypercholesterolemia
Sex Characteristics
Diabetes Mellitus
Population

Citer dette

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title = "The DanCavas Pilot Study of Multifaceted Screening for Subclinical Cardiovascular Disease in Men and Women Aged 65-74 Years",
abstract = "OBJECTIVE/BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD.METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c. Web based self booking and data management was used to reduce the administrative burden.RESULTS: Attendance rates were 64.9{\%} (n = 678) and 63.0{\%} (n = 640) for men and women, respectively. In total, 39.7{\%} received a recommendation for medical preventive actions. Prevalence of aneurysms was 12.4{\%} (95{\%} confidence interval [CI] 9.9-14.9) in men and 1.1{\%} (95{\%} CI 0.3-1.9) in women, respectively (p < .001). A CAC score > 400 was found in 37.8{\%} of men and 11.3{\%} of women (p < .001), along with a significant increase in median CAC score with age (p = .03). Peripheral arterial disease was more prevalent in men (18.8{\%}, 95{\%} CI 15.8-21.8) than in women (11.2{\%}, 95{\%} CI 8.7-13.6). No significant differences between the sexes were found with regard to newly discovered AF (men 1.3{\%}, women 0.5{\%}), potential hypertension (men 9.7{\%}, women 11.5{\%}), hypercholesterolemia (men 0.9{\%}, women 1.1{\%}) or diabetes mellitus (men 2.1{\%}, women 1.3{\%}).CONCLUSION: Owing to the higher prevalence of severe conditions, such as aneurysms and CAC ≥ 400, screening for CVD seemed more prudent in men than women. The attendance rates were acceptable compared with other screening programs and the logistical structure of the screening program proved successful.",
keywords = "Aortic aneurysm, Cardiovascular prevention, Computed tomography, Coronary calcium score, Peripheral arterial disease, Screening",
author = "Kvist, {T V} and Lindholt, {Jes Sanddal} and Rasmussen, {L M} and R S{\o}gaard and Jess Lambrechtsen and {Hald Steffensen}, Flemming and L Frost and Olsen, {M H} and Hans Mickley and Jesper Hallas and G Urbonaviciene and Martin Busk and Kenneth Egstrup and Diederichsen, {Axel Cosmus Pyndt}",
note = "Copyright {\^A}{\circledC} 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.ejvs.2016.10.010",
language = "English",
volume = "53",
pages = "123--131",
journal = "European Journal of Vascular and Endovascular Surgery",
issn = "1078-5884",
publisher = "Elsevier",
number = "1",

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The DanCavas Pilot Study of Multifaceted Screening for Subclinical Cardiovascular Disease in Men and Women Aged 65-74 Years. / Kvist, T V; Lindholt, Jes Sanddal; Rasmussen, L M; Søgaard, R; Lambrechtsen, Jess; Hald Steffensen, Flemming; Frost, L; Olsen, M H; Mickley, Hans; Hallas, Jesper; Urbonaviciene, G; Busk, Martin; Egstrup, Kenneth; Diederichsen, Axel Cosmus Pyndt.

I: European Journal of Vascular and Endovascular Surgery, Bind 53, Nr. 1, 01.01.2017, s. 123-131.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The DanCavas Pilot Study of Multifaceted Screening for Subclinical Cardiovascular Disease in Men and Women Aged 65-74 Years

AU - Kvist, T V

AU - Lindholt, Jes Sanddal

AU - Rasmussen, L M

AU - Søgaard, R

AU - Lambrechtsen, Jess

AU - Hald Steffensen, Flemming

AU - Frost, L

AU - Olsen, M H

AU - Mickley, Hans

AU - Hallas, Jesper

AU - Urbonaviciene, G

AU - Busk, Martin

AU - Egstrup, Kenneth

AU - Diederichsen, Axel Cosmus Pyndt

N1 - Copyright © 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - OBJECTIVE/BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD.METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c. Web based self booking and data management was used to reduce the administrative burden.RESULTS: Attendance rates were 64.9% (n = 678) and 63.0% (n = 640) for men and women, respectively. In total, 39.7% received a recommendation for medical preventive actions. Prevalence of aneurysms was 12.4% (95% confidence interval [CI] 9.9-14.9) in men and 1.1% (95% CI 0.3-1.9) in women, respectively (p < .001). A CAC score > 400 was found in 37.8% of men and 11.3% of women (p < .001), along with a significant increase in median CAC score with age (p = .03). Peripheral arterial disease was more prevalent in men (18.8%, 95% CI 15.8-21.8) than in women (11.2%, 95% CI 8.7-13.6). No significant differences between the sexes were found with regard to newly discovered AF (men 1.3%, women 0.5%), potential hypertension (men 9.7%, women 11.5%), hypercholesterolemia (men 0.9%, women 1.1%) or diabetes mellitus (men 2.1%, women 1.3%).CONCLUSION: Owing to the higher prevalence of severe conditions, such as aneurysms and CAC ≥ 400, screening for CVD seemed more prudent in men than women. The attendance rates were acceptable compared with other screening programs and the logistical structure of the screening program proved successful.

AB - OBJECTIVE/BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD.METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c. Web based self booking and data management was used to reduce the administrative burden.RESULTS: Attendance rates were 64.9% (n = 678) and 63.0% (n = 640) for men and women, respectively. In total, 39.7% received a recommendation for medical preventive actions. Prevalence of aneurysms was 12.4% (95% confidence interval [CI] 9.9-14.9) in men and 1.1% (95% CI 0.3-1.9) in women, respectively (p < .001). A CAC score > 400 was found in 37.8% of men and 11.3% of women (p < .001), along with a significant increase in median CAC score with age (p = .03). Peripheral arterial disease was more prevalent in men (18.8%, 95% CI 15.8-21.8) than in women (11.2%, 95% CI 8.7-13.6). No significant differences between the sexes were found with regard to newly discovered AF (men 1.3%, women 0.5%), potential hypertension (men 9.7%, women 11.5%), hypercholesterolemia (men 0.9%, women 1.1%) or diabetes mellitus (men 2.1%, women 1.3%).CONCLUSION: Owing to the higher prevalence of severe conditions, such as aneurysms and CAC ≥ 400, screening for CVD seemed more prudent in men than women. The attendance rates were acceptable compared with other screening programs and the logistical structure of the screening program proved successful.

KW - Aortic aneurysm

KW - Cardiovascular prevention

KW - Computed tomography

KW - Coronary calcium score

KW - Peripheral arterial disease

KW - Screening

U2 - 10.1016/j.ejvs.2016.10.010

DO - 10.1016/j.ejvs.2016.10.010

M3 - Journal article

C2 - 27890524

VL - 53

SP - 123

EP - 131

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

SN - 1078-5884

IS - 1

ER -