@article{fbecc6c085ce11df846a000ea68e967b,
title = "The coumarin herniarin as a sensitizer in German chamomile [Chamomilla recutita (L.) Rauschert, Compositae]",
abstract = "BACKGROUND: Although German chamomile (Chamomilla recutita) is considered a weak sensitizer, recent studies have shown several possible non-sesquiterpene lactone allergens in tea (infusions) from the plant. OBJECTIVE: The aim of this study was to report the results of patch testing with herniarin (7-methoxycoumarin), which is one of the possible coumarin allergens in chamomile. PATIENTS/MATERIALS/METHODS: Between 1991 and 2009, selected patients with known or suspected Compositae contact allergy were patch tested with herniarin 1\% petrolatum. RESULTS: Among 36 patients tested, there was one positive and three doubtful positive reactions to herniarin. All 4 patients had a relevant contact allergy to German chamomile, whereas the majority of the remaining 32 patients had chamomile allergy of unknown relevance. CONCLUSIONS: The clinical results suggest that herniarin indeed is one of the non-sesquiterpene lactone sensitizers in German chamomile and that sensitization may occur through, for example, external use of chamomile tea or use of chamomile-containing topical herbal remedies.",
author = "Evy Paulsen and Aksel Otkjaer and Andersen, \{Klaus E\}",
year = "2010",
month = jun,
day = "1",
doi = "10.1111/j.1600-0536.2010.01730.x",
language = "English",
volume = "62",
pages = "338--42",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley",
number = "6",
}